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Vaccines have proven effective in mitigating the threat of severe infections and deaths during outbreaks of infectious diseases. However, vaccine hesitancy (VH) complicates disease spread prediction and healthcare resource assessment across…

Optimization and Control · Mathematics 2024-05-10 Hieu Bui , Sandra Eksioglu , Ruben Proano , Haoming Shen

The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total…

The pursuit of strategies that minimize the number of individuals needing vaccination to control an outbreak is a well-established area of study in mathematical epidemiology. However, for certain diseases, public policy tends to prioritize…

Populations and Evolution · Quantitative Biology 2026-01-30 J. Orestes Cerdeira , Fabio A. C. C. Chalub , Matheus Hansen

Diverse and complex intervention policies deployed over the last years have shown varied effectiveness in controlling the COVID-19 pandemic. However, a systematic analysis and modelling of the combined effects of different viral lineages…

Populations and Evolution · Quantitative Biology 2023-06-27 Quang Dang Nguyen , Sheryl L. Chang , Christina M. Jamerlan , Mikhail Prokopenko

The current development of vaccines for SARS-CoV-2 is unprecedented. Little is known, however, about the nuanced public opinions on the vaccines on social media. We adopt a human-guided machine learning framework using more than six million…

Social and Information Networks · Computer Science 2021-08-10 Hanjia Lyu , Junda Wang , Wei Wu , Viet Duong , Xiyang Zhang , Timothy D. Dye , Jiebo Luo

The COVID-19 pandemic has so far accounted for reported 5.5M deaths worldwide, with 8.7% of these coming from India. The pandemic exacerbated the weakness of the Indian healthcare system. As of January 20, 2022, India is the second worst…

Computers and Society · Computer Science 2022-06-07 Tanvi Karandikar , Avinash Prabhu , Mehul Mathur , Megha Arora , Hemank Lamba , Ponnurangam Kumaraguru

Vaccination campaigns have both direct and indirect effects that act to control an infectious disease as it spreads through a population. Indirect effects arise when vaccinated individuals block disease transmission in any infection chains…

Populations and Evolution · Quantitative Biology 2024-05-08 Lixin Lin , Homayoun Hamedmoghadam , Robert Shorten , Lewi Stone

Anti-vaccine sentiments have been well-known and reported throughout the history of viral outbreaks and vaccination programmes. The COVID-19 pandemic had fear and uncertainty about vaccines which has been well expressed on social media…

Social and Information Networks · Computer Science 2023-06-27 Rohitash Chandra , Jayesh Sonawane , Janhavi Lande , Cathy Yu

Vaccination policies play a central role in public health interventions and models are often used to assess the effectiveness of these policies. Many vaccines are leaky, in which case the observed vaccine effectiveness depends on the force…

Populations and Evolution · Quantitative Biology 2025-04-21 Gray Manicom , Emily Harvey , Joshua Looker , David Wu , Oliver Maclaren , Dion O' Neale

This work presents a novel Model Predictive Control (MPC) approach to develop an optimal age-structured vaccination strategy for the containment of COVID-19 in Wallonia, Belgium. The proposed MPC framework is designed to minimize deaths,…

Optimization and Control · Mathematics 2026-02-17 Candy Sonveaux , Morgane Dumont , Mirko Fiacchini , Mohamad Ajami

Background: Network-based interventions are most powerful against epidemics when the full network structure is known. However, resource constraints often require decisions based on partial network data. We investigated how the effectiveness…

Populations and Evolution · Quantitative Biology 2018-03-30 Yingrui Yang , Ashley McKhann , Guy Harling , Jukka-Pekka Onnela

We aim to design a fairness-aware allocation approach to maximize the geographical diversity and avoid unfairness in the sense of demographic disparity. During the development of this work, the COVID-19 pandemic is still spreading in the…

Optimization and Control · Mathematics 2026-05-12 Hadis Anahideh , Lulu Kang , Nazanin Nezami

We propose a multi-layer network model for the spread of COVID-19 that accounts for interactions within the family, between schoolmates, and casual contacts in the population. We utilize the proposed model-calibrated on epidemiological and…

Physics and Society · Physics 2021-03-24 Christian Bongiorno , Lorenzo Zino

During the COVID-19 pandemic, estimating the total deaths averted by vaccination has been of great public health interest. Instead of estimating total deaths averted by vaccination among both vaccinated and unvaccinated individuals, some…

Populations and Evolution · Quantitative Biology 2025-10-09 Katherine M. Jia , Christopher B. Boyer , Alyssa Bilinski , Marc Lipsitch

The risk for severe illness and mortality from COVID-19 significantly increases with age. As a result, age-stratified modeling for COVID-19 dynamics is the key to study how to reduce hospitalizations and mortality from COVID-19. By taking…

Populations and Evolution · Quantitative Biology 2021-05-12 Xianhao Chen , Guangyu Zhu , Lan Zhang , Yuguang Fang , Linke Guo , Xinguang Chen

During the COVID-19 pandemic, regulatory decision-making was hampered by a lack of timely and high-quality data on rare outcomes. Studying rare outcomes following infection and vaccination requires conducting multi-center observational…

Methodology · Statistics 2025-07-22 Malcolm Risk , Xu Shi , Lili Zhao

We formalize and study the problem of optimal allocation strategies for a (perfect) vaccine in the infinite-dimensional SIS model. The question may be viewed as a bi-objective minimization problem, where one tries to minimize simultaneously…

Probability · Mathematics 2021-08-27 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Voluntary vaccination is essential to protect oneself from infection and suppress the spread of infectious diseases. Voluntary vaccination behavior is influenced by factors such as age and interaction patterns. Differences in health…

Physics and Society · Physics 2024-12-11 Yanyi Nie , Tao Lin , Yanbing Liu , Wei Wang

Global problems, such as pandemics and climate change, require rapid international coordination and diffusion of policy. These phenomena are rare however, with one notable example being the international policy response to the COVID-19…

Multiagent Systems · Computer Science 2023-02-23 Yannick Oswald , Nick Malleson , Keiran Suchak

With the approval of vaccines for the coronavirus disease by many countries worldwide, most developed nations have begun, and developing nations are gearing up for the vaccination process. This has created an urgent need to provide a…

Computers and Society · Computer Science 2021-02-09 Mahzabeen Emu , Dhivya Chandrasekaran , Vijay Mago , Salimur Choudhury
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