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In recent years, Artificial Intelligence (AI) has proven its relevance for medical decision support. However, the "black-box" nature of successful AI algorithms still holds back their wide-spread deployment. In this paper, we describe an…

Computer Vision and Pattern Recognition · Computer Science 2021-07-23 Gwenolé Quellec , Hassan Al Hajj , Mathieu Lamard , Pierre-Henri Conze , Pascale Massin , Béatrice Cochener

Diabetic retinopathy is a common complication of diabetes, and monitoring the progression of retinal abnormalities using fundus imaging is crucial. Because the images must be interpreted by a medical expert, it is infeasible to screen all…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Andrea M. Storås , Josefine V. Sundgaard

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

The increasing prevalence of retinal diseases poses a significant challenge to the healthcare system, as the demand for ophthalmologists surpasses the available workforce. This imbalance creates a bottleneck in diagnosis and treatment,…

Image and Video Processing · Electrical Eng. & Systems 2024-08-15 Jia-Hong Huang

Deep neural network models have been proven to be very successful in image classification tasks, also for medical diagnosis, but their main concern is its lack of interpretability. They use to work as intuition machines with high…

Machine Learning · Computer Science 2019-04-26 Jordi de la Torre , Aida Valls , Domenec Puig

Retinal imaging provides a non-invasive window into systemic microvascular health and has emerged as a potential biomarker for systemic diseases. However, whether retinal features encode biologically meaningful systemic signals that can be…

Image and Video Processing · Electrical Eng. & Systems 2026-05-26 Mini Han Wang , Liting Huang , Wei Hong , Boonthawan Wingwon

In this work, we propose an AI-based method that intends to improve the conventional retinal disease treatment procedure and help ophthalmologists increase diagnosis efficiency and accuracy. The proposed method is composed of a deep neural…

Computer Vision and Pattern Recognition · Computer Science 2020-11-03 Jia-Hong Huang , Chao-Han Huck Yang , Fangyu Liu , Meng Tian , Yi-Chieh Liu , Ting-Wei Wu , I-Hung Lin , Kang Wang , Hiromasa Morikawa , Hernghua Chang , Jesper Tegner , Marcel Worring

The increasing prevalence of retinal diseases poses a significant challenge to the healthcare system, as the demand for ophthalmologists surpasses the available workforce. This imbalance creates a bottleneck in diagnosis and treatment,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-17 Jia-Hong Huang

Remarkable success of modern image-based AI methods and the resulting interest in their applications in critical decision-making processes has led to a surge in efforts to make such intelligent systems transparent and explainable. The need…

Artificial Intelligence · Computer Science 2020-11-30 Adriano Lucieri , Muhammad Naseer Bajwa , Andreas Dengel , Sheraz Ahmed

Inherited retinal diseases (IRDs) are a diverse group of genetic disorders that lead to progressive vision loss and are a major cause of blindness in working-age adults. The complexity and heterogeneity of IRDs pose significant challenges…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Han Trinh , Jordan Vice , Jason Charng , Zahra Tajbakhsh , Khyber Alam , Fred K. Chen , Ajmal Mian

Retinal imaging has emerged as a powerful, non-invasive modality for detecting and quantifying biomarkers of systemic diseases-ranging from diabetes and hypertension to Alzheimer's disease and cardiovascular disorders but current insights…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Tariq M Khan , Toufique Ahmed Soomro , Imran Razzak

This paper provides a systematic survey of retinal diseases that cause visual impairments or blindness, emphasizing the importance of early detection for effective treatment. It covers both clinical and automated approaches for detecting…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Hina Raja , Taimur Hassan , Bilal Hassan , Muhammad Usman Akram , Hira Raja , Alaa A Abd-alrazaq , Siamak Yousefi , Naoufel Werghi

Diabetic Retinopathy (DR) affects individuals with long-term diabetes. Without early diagnosis, DR can lead to vision loss. Fundus photography captures the structure of the retina along with abnormalities indicative of the stage of the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Anca Mihai , Adrian Groza

Though deep learning has shown successful performance in classifying the label and severity stage of certain diseases, most of them give few explanations on how to make predictions. Inspired by Koch's Postulates, the foundation in…

Image and Video Processing · Electrical Eng. & Systems 2022-05-02 Yuhao Niu , Lin Gu , Yitian Zhao , Feng Lu

In recent years, the incidence of vision-threatening eye diseases has risen dramatically, necessitating scalable and accurate screening solutions. This paper presents a comprehensive study on deep learning architectures for the automated…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Mohammad Sadegh Gholizadeh , Amir Arsalan Rezapour

In response to the global challenge of mental health problems, we proposes a Logical Neural Network (LNN) based Neuro-Symbolic AI method for the diagnosis of mental disorders. Due to the lack of effective therapy coverage for mental…

Computation and Language · Computer Science 2023-06-07 Yeldar Toleubay , Don Joven Agravante , Daiki Kimura , Baihan Lin , Djallel Bouneffouf , Michiaki Tatsubori

The emergence of artificial intelligence (AI), particularly deep learning (DL), has marked a new era in the realm of ophthalmology, offering transformative potential for the diagnosis and treatment of posterior segment eye diseases. This…

Image and Video Processing · Electrical Eng. & Systems 2025-01-09 Duy M. H. Nguyen , Hasan Md Tusfiqur Alam , Tai Nguyen , Devansh Srivastav , Hans-Juergen Profitlich , Ngan Le , Daniel Sonntag

In this paper, we propose an explainable and interpretable diabetic retinopathy (ExplainDR) classification model based on neural-symbolic learning. To gain explainability, a highlevel symbolic representation should be considered in decision…

Machine Learning · Computer Science 2022-04-05 Se-In Jang , Michael J. A. Girard , Alexandre H. Thiery

Automatic segmentation of retina vessels plays a pivotal role in clinical diagnosis of prevalent eye diseases, such as, Diabetic Retinopathy or Age-related Macular Degeneration. Due to the complex construction of blood vessels, with…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Benjamin Hou

Diabetes mellitus (DM) predisposes patients to vascular complications. Retinal images and vasculature reflect the body's micro- and macrovascular health. They can be used to diagnose DM complications, including diabetic retinopathy (DR),…

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