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The distributed nature of the neural substrate, and the difficulty of establishing necessity from correlative data, combine to render the mapping of brain function a far harder task than it seems. Methods capable of combining connective…

For neurological disorders and diseases, functional and anatomical connectomes of the human brain can be used to better inform targeted interventions and treatment strategies. Functional magnetic resonance imaging (fMRI) is a non-invasive…

Methodology · Statistics 2023-07-03 Matt Ryan , Gary Glonek , Jono Tuke , Melissa Humphries

Generating realistic brain connectivity matrices is key to analyzing population heterogeneity in brain organization, understanding disease, and augmenting data in challenging classification problems. Functional connectivity matrices lie in…

Machine Learning · Computer Science 2025-10-27 Antoine Collas , Ce Ju , Nicolas Salvy , Bertrand Thirion

Existing multimodal stress/pain recognition approaches generally extract features from different modalities independently and thus ignore cross-modality correlations. This paper proposes a novel geometric framework for multimodal…

Machine Learning · Computer Science 2022-07-20 Yujin WU , Mohamed Daoudi , Ali Amad , Laurent Sparrow , Fabien D'Hondt

The analysis of non-stationary time-series data requires insight into its local and global patterns with physical interpretability. However, traditional smoothing algorithms, such as B-splines, Savitzky-Golay filtering, and Empirical Mode…

Signal Processing · Electrical Eng. & Systems 2026-02-25 Teymur Aghayev

In humans, the tactile perception of fine textures is mediated by skin vibrations when scanning the surface with the fingertip. These vibrations are encoded by specific mechanoreceptors, Pacinian corpuscules (PCs), located about 2 mm below…

Medical Physics · Physics 2009-11-18 Alexis Prevost , Julien Scheibert , Georges Debrégeas

Functional connectivity is a key approach to investigate oscillatory activities of the brain that provides important insights on the underlying dynamic of neuronal interactions and that is mostly applied for brain activity analysis.…

Neurons and Cognition · Quantitative Biology 2022-02-17 Marie-Constance Corsi , Sylvain Chevallier , Fabrizio De Vico Fallani , Florian Yger

By focusing on melancholic features with biological homogeneity, this study aimed to identify a small number of critical functional connections (FCs) that were specific only to the melancholic type of MDD. On the resting-state fMRI data,…

Dynamic functional connectivity (dFC) using resting-state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for capturing the dynamic changes of neural activities, and can be very useful in the studies of brain…

Image and Video Processing · Electrical Eng. & Systems 2025-01-29 Jing Zhang , Yanjun Lyu , Xiaowei Yu , Lu Zhang , Chao Cao , Tong Chen , Minheng Chen , Yan Zhuang , Tianming Liu , Dajiang Zhu

The formation of transient networks in response to external stimuli or as a reflection of internal cognitive processes is a hallmark of human brain function. However, its identification in fMRI data of the human brain is notoriously…

Neurons and Cognition · Quantitative Biology 2016-12-05 Gabriele Lohmann , Johannes Stelzer , Verena Zuber , Tilo Buschmann , Daniel Margulies , Andreas Bartels , Klaus Scheffler

The contribution of structural connectivity to functional brain states remains poorly understood. We present a mathematical and computational study suited to assess the structure--function issue, treating a system of Jansen--Rit neural-mass…

Neurons and Cognition · Quantitative Biology 2020-07-10 Michael Forrester , Stephen Coombes , Jonathan J. Crofts , Stamatios N. Sotiropoulos , Reuben D. O'Dea

The brain's complex functionality emerges from network interactions that go beyond dyadic connections, with higher-order interactions significantly contributing to this complexity. One method of capturing higher-order interactions is…

Neurons and Cognition · Quantitative Biology 2024-06-11 Behdad Khodabandehloo , Payam Jannatdoust , Babak Nadjar Araabi

Fingerprinting-based positioning significantly improves the indoor localization performance in non-line-of-sight-dominated areas. However, its deployment and maintenance is cost-intensive as it needs ground-truth reference systems for both…

Signal Processing · Electrical Eng. & Systems 2022-10-13 Maximilian Stahlke , George Yammine , Tobias Feigl , Bjoern M. Eskofier , Christopher Mutschler

Connectomics has emerged as a powerful tool in neuroimaging and has spurred recent advancements in statistical and machine learning methods for connectivity data. Despite connectomes inhabiting a matrix manifold, most analytical frameworks…

Quantitative Methods · Quantitative Biology 2023-03-28 Niharika S. D'Souza , Archana Venkataraman

Understanding associations between paired high-dimensional longitudinal datasets is a fundamental yet challenging problem that arises across scientific domains, including longitudinal multi-omic studies. The difficulty stems from the…

Methodology · Statistics 2026-01-21 Jianbin Tan , Pixu Shi

Surface meshes are widely used shape representations and capture finer geometry data than point clouds or volumetric grids, but are challenging to apply CNNs directly due to their non-Euclidean structure. We use parallel frames on surface…

Computer Vision and Pattern Recognition · Computer Science 2020-06-15 Yuqi Yang , Shilin Liu , Hao Pan , Yang Liu , Xin Tong

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

Targeted electrical stimulation of the brain perturbs neural networks and modulates their rhythmic activity both at the site of stimulation and at remote brain regions. Understanding, or even predicting, this neuromodulatory effect is…

Neurons and Cognition · Quantitative Biology 2021-06-29 Christoforos Papasavvas , Peter Neal Taylor , Yujiang Wang

Accurate segmentation of long and thin tubular structures is required in a wide variety of areas such as biology, medicine, and remote sensing. The complex topology and geometry of such structures often pose significant technical…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Jiaxing Huang , Yanfeng Zhou , Yaoru Luo , Guole Liu , Heng Guo , Ge Yang

In recent years, graph neural networks (GNNs) have been widely applied in the analysis of brain fMRI, yet defining the connectivity between ROIs remains a challenge in noisy fMRI data. Among all approaches, Functional Connectome (FC) is the…

Machine Learning · Computer Science 2025-04-09 Jiyao Wang , Nicha C. Dvornek , Peiyu Duan , Lawrence H. Staib , Pamela Ventola , James S. Duncan