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Recent advances in large foundation models, such as the Segment Anything Model (SAM), have demonstrated considerable promise across various tasks. Despite their progress, these models still encounter challenges in specialized medical image…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Wenxue Li , Xinyu Xiong , Peng Xia , Lie Ju , Zongyuan Ge

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Deep learning has been successfully applied to a variety of image classification tasks. There has been keen interest to apply deep learning in the medical domain, particularly specialties that heavily utilize imaging, such as ophthalmology.…

Machine Learning · Computer Science 2019-02-13 Rony Gelman

Early detection of diabetic retinopathy prevents visual loss and blindness of a human eye. Based on the types of feature extraction method used, DR detection method can be broadly classified as Deep Convolutional Neural Network (CNN) based…

Image and Video Processing · Electrical Eng. & Systems 2020-01-01 Asma Khatun , Sk. Golam Sarowar Hossain

Age-related Macular Degeneration (AMD) is a leading cause of blindness. Although the Age-Related Eye Disease Study group previously developed a 9-step AMD severity scale for manual classification of AMD severity from color fundus images,…

Machine Learning · Computer Science 2018-12-04 Qingyu Chen , Yifan Peng , Tiarnan Keenan , Shazia Dharssi , Elvira Agron , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

Deep neural networks (DNNs) have achieved remarkable success across domains but remain difficult to interpret, limiting their trustworthiness in high-stakes applications. This paper focuses on deep vision models, for which a dominant line…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Qiming Zhao , Xingjian Li , Xiaoyu Cao , Xiaolong Wu , Min Xu

The identification and quantification of markers in medical images is critical for diagnosis, prognosis and management of patients in clinical practice. Supervised- or weakly supervised training enables the detection of findings that are…

We present Gradient Activation Maps (GAM) - a machinery for explaining predictions made by visual similarity and classification models. By gleaning localized gradient and activation information from multiple network layers, GAM offers…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Oren Barkan , Omri Armstrong , Amir Hertz , Avi Caciularu , Ori Katz , Itzik Malkiel , Noam Koenigstein

Deep learning models have been successfully used in medical image analysis problems but they require a large amount of labeled images to obtain good performance.Deep learning models have been successfully used in medical image analysis…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Asim Smailagic , Hae Young Noh , Pedro Costa , Devesh Walawalkar , Kartik Khandelwal , Mostafa Mirshekari , Jonathon Fagert , Adrián Galdrán , Susu Xu

Assessing the degree of disease severity in biomedical images is a task similar to standard classification but constrained by an underlying structure in the label space. Such a structure reflects the monotonic relationship between different…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Adrian Galdran , José Dolz , Hadi Chakor , Hervé Lombaert , Ismail Ben Ayed

Deep learning is currently the state-of-the-art for automated detection of referable diabetic retinopathy (DR) from color fundus photographs (CFP). While the general interest is put on improving results through methodological innovations,…

Image and Video Processing · Electrical Eng. & Systems 2022-10-10 Tomás Castilla , Marcela S. Martínez , Mercedes Leguía , Ignacio Larrabide , José Ignacio Orlando

Diabetic retinopathy is a leading cause of vision loss among adults and a major global health challenge, particularly in underserved regions. This study presents PerceptronCARE, a deep learning-based teleophthalmology application designed…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Akwasi Asare , Isaac Baffour Senkyire , Emmanuel Freeman , Mary Sagoe , Simon Hilary Ayinedenaba Aluze-Ele , Kelvin Kwao

Diabetic retinopathy (DR), affecting millions globally with projections indicating a significant rise, poses a severe blindness risk and strains healthcare systems. Diagnostic complexity arises from visual symptom overlap with conditions…

Image and Video Processing · Electrical Eng. & Systems 2026-01-14 Susmita Kar , A S M Ahsanul Sarkar Akib , Abdul Hasib , Samin Yaser , Anas Bin Azim

In this paper, we propose a novel selection strategy for contrastive learning for medical images. On natural images, contrastive learning uses augmentations to select positive and negative pairs for the contrastive loss. However, in the…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Kiran Kokilepersaud , Mohit Prabhushankar , Ghassan AlRegib , Stephanie Trejo Corona , Charles Wykoff

Diabetic Retinopathy (DR) is a prevalent illness associated with Diabetes which, if left untreated, can result in irreversible blindness. Deep Learning based systems are gradually being introduced as automated support for clinical…

Image and Video Processing · Electrical Eng. & Systems 2023-12-14 Samrat Mukherjee , Dibyanayan Bandyopadhyay , Baban Gain , Asif Ekbal

Eye diseases are common in older Americans and can lead to decreased vision and blindness. Recent advancements in imaging technologies allow clinicians to capture high-quality images of the retinal blood vessels via Optical Coherence…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Jacob Thrasher , Annahita Amireskandari , Prashnna Gyawali

Domain generalization for Diabetic Retinopathy (DR) classification allows a model to adeptly classify retinal images from previously unseen domains with various imaging conditions and patient demographics, thereby enhancing its…

Computer Vision and Pattern Recognition · Computer Science 2023-09-21 Sharon Chokuwa , Muhammad H. Khan

Artificial intelligence algorithms have demonstrated their image classification and segmentation ability in the past decade. However, artificial intelligence algorithms perform less for actual clinical data than those used for simulations.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Mostafa Hajighasemlou , Samad Sheikhaei , Hamid Soltanian-Zadeh

Purpose: To demonstrate that retinal microvasculature per se is a reliable biomarker for Diabetic Retinopathy (DR) and, by extension, cardiovascular diseases. Methods: Deep Learning Convolutional Neural Networks (CNN) applied to color…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Anusua Trivedi , Jocelyn Desbiens , Ron Gross , Sunil Gupta , Rahul Dodhia , Juan Lavista Ferres

Deep learning has demonstrated expert-level performance in melanoma classification, positioning it as a powerful tool in clinical dermatology. However, model opacity and the lack of interpretability remain critical barriers to clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Junwen Zheng , Xinran Xu , Li Rong Wang , Chang Cai , Lucinda Siyun Tan , Dingyuan Wang , Hong Liang Tey , Xiuyi Fan