Related papers: Whole Brain Network Dynamics of Epileptic Seizures…
Persistent activity is postulated to drive neural network plasticity and learning. To investigate its underlying cellular mechanisms, we developed a biophysically tractable model that explains the emergence, sustenance, and eventual…
Even when driven by the same stimulus, neuronal responses are well-known to exhibit a striking level of spiking variability. In-vivo electrophysiological recordings also reveal a surprisingly large degree of variability at the subthreshold…
Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter…
Epilepsy creates a persistent increase in the probability of spontaneous seizures. An ictal episode evolves due to acute disturbance of the fine-tuned balance between excitatory vs. inhibitory inputs within a neural network in favor of…
Cortical network functioning critically depends on finely tuned interactions to afford neuronal activity propagation over long distances while avoiding runaway excitation. This importance is highlighted by the pathological consequences and…
Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the…
Over one third of the estimated 3 million people with epilepsy in the US are medication resistant. Responsive neurostimulation from chronically implanted electrodes provides a promising treatment option and alternative to resective surgery.…
Consciousness spans macroscopic experience and microscopic neuronal activity, yet linking these scales remains challenging. Prevailing theories, such as Integrated Information Theory, focus on a single scale, overlooking how causal power…
Epilepsy is one of the most common neurological disorders that greatly impair patient' daily lives. Traditional epileptic diagnosis relies on tedious visual screening by neurologists from lengthy EEG recording that requires the presence of…
Epilepsy is common neurological diseases, affecting about 0.6-0.8 % of world population. Epileptic patients suffer from chronic unprovoked seizures, which can result in broad spectrum of debilitating medical and social consequences. Since…
The underlying dynamics for the electroencephalographic (EEG) recordings from humans but especially epilepsy patients are usually not completely known. However, the ictal activity is claimed to be characterized by synchronous oscillations…
We study the role of scale-free structure and noise in collective dynamics of neuronal networks. For this purpose, we simulate and study analytically a cortical circuit model with stochastic neurons. We compare collective neuronal activity…
Epilepsy is a common, chronic neurological disorder characterized by recurrent seizures caused by sudden bursts of abnormal electrical activity in the brain. Seizures can often be unpredictable, leading to uncertainty and anxiety for people…
While most models of randomly connected networks assume nodes with simple dynamics, nodes in realistic highly connected networks, such as neurons in the brain, exhibit intrinsic dynamics over multiple timescales. We analyze how the…
Cortical activity in-vivo displays relaxational time scales much longer than the membrane time constant of the neurons or the deactivation time of ionotropic synaptic conductances. The mechanisms responsible for such slow dynamics are not…
When a neuron fires and the resulting action potential travels down its axon toward other neurons' dendrites, the effect on each of those neurons is mediated by the weight of the synapse that separates it from the firing neuron. This…
Neural activity patterns related to behavior occur at many scales in time and space from the atomic and molecular to the whole brain. Here we explore the feasibility of interpreting neurophysiological data in the context of many-body…
Epilepsy, affecting approximately 50 million people globally, is characterized by abnormal brain activity and remains challenging to treat. The diagnosis of epilepsy relies heavily on electroencephalogram (EEG) data, where specialists…
Epilepsy is one of the most occurring neurological disease globally emerged back in 4000 BC. It is affecting around 50 million people of all ages these days. The trait of this disease is recurrent seizures. In the past few decades, the…
We calculate a measure of statistical complexity from the global dynamics of electroencephalographic (EEG) signals from healthy subjects and epileptic patients, and are able to stablish a criterion to characterize the collective behavior in…