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Related papers: Information retrieval in single cell chromatin ana…

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Single-cell RNA-sequencing technologies may provide valuable insights to the understanding of the composition of different cell types and their functions within a tissue. Recent technologies such as spatial transcriptomics, enable the…

Applications · Statistics 2023-05-16 Arhit Chakrabarti , Yang Ni , Bani K. Mallick

Spatially resolved transcriptomics brings exciting breakthroughs to single-cell analysis by providing physical locations along with gene expression. However, as a cost of the extremely high spatial resolution, the cellular level spatial…

Genomics · Quantitative Biology 2024-02-19 Hongzhi Wen , Wenzhuo Tang , Wei Jin , Jiayuan Ding , Renming Liu , Xinnan Dai , Feng Shi , Lulu Shang , Hui Liu , Yuying Xie

We revisit a singular value decomposition (SVD) algorithm given in Chen et al. (2019b) for exploratory Item Factor Analysis (IFA). This algorithm estimates a multidimensional IFA model by SVD and was used to obtain a starting point for…

Methodology · Statistics 2025-01-08 Haoran Zhang , Yunxiao Chen , Xiaoou Li

We present an alternative method for carrying out a principal-component analysis of Wilson coefficients in standard model effective field theory (SMEFT). The method is based on singular-value decomposition (SVD). The SVD method provides…

High Energy Physics - Phenomenology · Physics 2020-07-03 Geoffrey T. Bodwin , Hee Sok Chung

By using unsupervised domain adaptation (UDA), knowledge can be transferred from a label-rich source domain to a target domain that contains relevant information but lacks labels. Many existing UDA algorithms suffer from directly using raw…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Le Luo , Bingrong Xu , Qingyong Zhang , Cheng Lian , Jie Luo

Independent component analysis (ICA), as an approach to the blind source-separation (BSS) problem, has become the de-facto standard in many medical imaging settings. Despite successes and a large ongoing research effort, the limitation of…

Machine Learning · Computer Science 2016-03-23 R. Devon Hjelm , Sergey M. Plis , Vince C. Calhoun

Single-cell foundation models (scFMs) have demonstrated state-of-the-art performance on various tasks, such as cell-type annotation and perturbation response prediction, by learning gene regulatory networks from large-scale transcriptome…

Machine Learning · Computer Science 2025-09-19 Sosuke Hosokawa , Toshiharu Kawakami , Satoshi Kodera , Masamichi Ito , Norihiko Takeda

Over the last years, the SWATH data-independent acquisition protocol (Sequential Window acquisition of All THeoretical mass spectra) has become a cornerstone for the worldwide proteomics community. In this approach, a high-resolution…

Quantitative Methods · Quantitative Biology 2019-03-18 Clarissa Braccia , Meritxell Pons Espinal , Mattia Pini , Davide De Pietri Tonelli , Andrea Armirotti

Motivation: Advances in high-throughput chromatin conformation capture have provided insight into the three-dimensional structure and organization of chromatin. While bulk Hi-C experiments capture spatio-temporally averaged chromatin…

Genomics · Quantitative Biology 2026-05-28 Luka Maisuradze , Corey S. O'Hern , Mark D. Shattuck

The realm of classical phase retrieval concerns itself with the arduous task of recovering a signal from its Fourier magnitude measurements, which are fraught with inherent ambiguities. A single-exposure intensity measurement is commonly…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Yixiao Yang , Ran Tao , Kaixuan Wei , Jun Shi

In high-dimensional and high-stakes contexts, ensuring both rigorous statistical guarantees and interpretability in feature extraction from complex tabular data remains a formidable challenge. Traditional methods such as Principal Component…

Machine Learning · Computer Science 2025-03-25 Xiaochen Zhang , Haoyi Xiong

Nonlinear spatial encoding magnetic (SEM) fields have been studied to complement multichannel RF encoding and accelerate MRI scans. Published schemes include PatLoc, O-Space, Null Space, 4D-RIO, and others, but the large variety of possible…

Medical Physics · Physics 2016-11-18 Haifeng Wang , R. Todd Constable , Gigi Galiana

Faraday tomography offers crucial information on the magnetized astronomical objects, such as quasars, galaxies, or galaxy clusters, by observing its magnetoionic media. The observed linear polarization spectrum is inverse Fourier…

Instrumentation and Methods for Astrophysics · Physics 2020-11-24 Suchetha Cooray , Tsutomu T. Takeuchi , Takuya Akahori , Yoshimitsu Miyashita , Shinsuke Ideguchi , Keitaro Takahashi , Kiyotomo Ichiki

The extraction of information carried by light plays an increasingly important role in optical communication, imaging, and detection. However, the information can only be successfully extracted when the light pulse is comparably strong,…

Optics · Physics 2026-05-25 Zhen Yang , Zeng-Quan Yan , Li Wang , Xiao-Wei Wang , Ka-Di Zhu , Xian-Min Jin

Time-frequency analysis (TFA) techniques play an important role in the field of machine fault diagnosis attributing to their superiority in dealing with nonstationary signals. Synchroextracting transform (SET) and transient-extracting…

Signal Processing · Electrical Eng. & Systems 2024-02-09 Yunlong Ma , Gang Yu , Tianran Lin , Qingtang Jiang

While single-cell RNA sequencing provides an understanding of the transcriptome of individual cells, its high sparsity, often termed dropout, hampers the capture of significant cell-cell relationships. Here, we propose scFP (single-cell…

Computational Engineering, Finance, and Science · Computer Science 2023-07-24 Sukwon Yun , Junseok Lee , Chanyoung Park

RNA-Seq technology allows for studying the transcriptional state of the cell at an unprecedented level of detail. Beyond quantification of whole-gene expression, it is now possible to disentangle the abundance of individual alternatively…

Genomics · Quantitative Biology 2012-10-11 Barbara Rakitsch , Christoph Lippert , Hande Topa , Karsten Borgwardt , Antti Honkela , Oliver Stegle

Time series classification holds broad application value in communications, information countermeasures, finance, and medicine. However, state-of-the-art (SOTA) methods-including HIVE-COTE, Proximity Forest, and TS-CHIEF-exhibit high…

Machine Learning · Computer Science 2025-11-04 Wang Hao , Kuang Zhang , Hou Chengyu , Yuan Zhonghao , Tan Chenxing , Fu Weifeng , Zhu Yangying

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

Recent developments in high-power ultrafast optical technology and emerging theoretical frameworks in strong-field quantum electrodynamics (SF-QED) are unveiling nuanced differentiations between the semi-classical and full quantum…