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The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Human memory is inherently prone to forgetting. To address this, multimodal embedding models have been introduced, which transform diverse real-world data into a unified embedding space. These embeddings can be retrieved efficiently, aiding…

Information Retrieval · Computer Science 2024-09-25 Dongqi Cai , Shangguang Wang , Chen Peng , Zeling Zhang , Mengwei Xu

Scientific metadata often suffer from incompleteness, inconsistency, and formatting errors, which hinder effective discovery and reuse of the associated datasets. We present a method that combines GPT-4 with structured metadata templates…

Information Retrieval · Computer Science 2025-06-10 Sowmya S Sundaram , Rafael S. Gonçalves , Mark A Musen

The training data in large language models is key to their success, but it also presents privacy and security risks, as it may contain sensitive information. Detecting pre-training data is crucial for mitigating these concerns. Existing…

Computation and Language · Computer Science 2025-01-16 Cheng Wang , Yiwei Wang , Bryan Hooi , Yujun Cai , Nanyun Peng , Kai-Wei Chang

We propose Beam Tree Recursive Cell (BT-Cell) - a backpropagation-friendly framework to extend Recursive Neural Networks (RvNNs) with beam search for latent structure induction. We further extend this framework by proposing a relaxation of…

Machine Learning · Computer Science 2023-06-21 Jishnu Ray Chowdhury , Cornelia Caragea

Target speaker extraction (TSE) aims to isolate a specific speaker's speech from a mixture using speaker enrollment as a reference. While most existing approaches are discriminative, recent generative methods for TSE achieve strong results.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-21 Aviv Navon , Aviv Shamsian , Yael Segal-Feldman , Neta Glazer , Gil Hetz , Joseph Keshet

Large language models have revolutionized natural language processing through self-supervised pretraining on massive datasets. Inspired by this success, researchers have explored adapting these methods to speech by discretizing continuous…

Machine Learning · Computer Science 2025-10-28 Luca Della Libera , Francesco Paissan , Cem Subakan , Mirco Ravanelli

There is growing interest in the automated extraction of relevant information from clinical dialogues. However, it is difficult to collect and construct large annotated resources for clinical dialogue tasks. Recent developments in natural…

Computation and Language · Computer Science 2022-06-07 Zhengyuan Liu , Pavitra Krishnaswamy , Nancy F. Chen

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions to billions of short DNA fragments known as reads. Read mapping aligns these reads to a…

The goal of decompilation is to convert compiled low-level code (e.g., assembly code) back into high-level programming languages, enabling analysis in scenarios where source code is unavailable. This task supports various reverse…

Software Engineering · Computer Science 2025-02-19 Yunlong Feng , Bohan Li , Xiaoming Shi , Qingfu Zhu , Wanxiang Che

Progress in speech processing has been facilitated by shared datasets and benchmarks. Historically these have focused on automatic speech recognition (ASR), speaker identification, or other lower-level tasks. Interest has been growing in…

Computation and Language · Computer Science 2022-08-01 Suwon Shon , Ankita Pasad , Felix Wu , Pablo Brusco , Yoav Artzi , Karen Livescu , Kyu J. Han

Many benchmarks for automated causal inference evaluate a system's performance based on a single numerical output, such as an Average Treatment Effect (ATE). This approach conflates two distinct steps in causal analysis: identification -…

Artificial Intelligence · Computer Science 2026-05-15 Ayush Sawarni , Jiyuan Tan , Vasilis Syrgkanis

Motivation: Seed location filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. State-of-the-art read…

Systematic ablations are essential to attribute performance gains in AI Virtual Cells, yet they are rarely performed because biological repositories are under-standardized and tightly coupled to domain-specific data and formats. While…

Artificial Intelligence · Computer Science 2026-05-01 Xue Xia , Chengkai Yao , Mingyu Tsoi , Xinjie Mao , Wenxuan Huang , Jiaqi Wei , Hao Wu , Cheng Tan , Lang Yu , Yuejin Yang , Mengdi Liu , Siqi Sun , Zhangyang Gao

Language-queried target sound extraction (TSE) aims to extract specific sounds from mixtures based on language queries. Traditional fully-supervised training schemes require extensively annotated parallel audio-text data, which are…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-24 Hao Ma , Zhiyuan Peng , Xu Li , Yukai Li , Mingjie Shao , Qiuqiang Kong , Ju Liu

Motivation: Next generation methods of DNA sequencing produce relatively high rate of reading errors, which interfere with de novo genome assembly of newly sequenced organisms and particularly affect the quality of SNP detection important…

Genomics · Quantitative Biology 2019-07-31 Oleg Fokin , Anastasia Bakulina , Igor Seledtsov , Victor Solovyev

Contrarily to humans who have the ability to recombine familiar expressions to create novel ones, modern neural networks struggle to do so. This has been emphasized recently with the introduction of the benchmark dataset "gSCAN" (Ruis et…

Machine Learning · Computer Science 2020-10-02 Christina Heinze-Deml , Diane Bouchacourt

Automated single-cell annotation is difficult when the most abundant genes are not the most discriminative ones, or when a target state is poorly covered by a fixed reference atlas. GPTCelltype-style one-shot prompting allows large language…

Quantitative Methods · Quantitative Biology 2026-05-08 Yehui Yang , Zelin Zang , Xienan Zheng , Yuzhe Jia , Changxi Chi , Jingbo Zhou , Chang Yu , Jinlin Wu , Fuji Yang , Jiebo Luo , Zhen Lei , Stan Z. Li

Recent studies have shown that neural vocoders based on generative adversarial network (GAN) can generate audios with high quality. While GAN based neural vocoders have shown to be computationally much more efficient than those based on…

Sound · Computer Science 2021-06-28 Zhengxi Liu , Yanmin Qian