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Two successful approaches for the segmentation of biomedical images are (1) the selection of segment candidates from a merge-tree, and (2) the clustering of small superpixels by solving a Multi-Cut problem. In this paper, we introduce a…

Computer Vision and Pattern Recognition · Computer Science 2017-07-05 Jan Funke , Chong Zhang , Tobias Pietzsch , Stephan Saalfeld

Medical image segmentation requires not only accuracy but also robustness under challenging imaging conditions. In this study, we show that a carefully configured DeepLabv3 model can achieve high performance in segmenting induced…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Maoquan Zhang , Bisser Raytchev , Xiujuan Sun

Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

Multimodal Magnetic Resonance Imaging (MRI) provides essential complementary information for analyzing brain tumor subregions. While methods using four common MRI modalities for automatic segmentation have shown success, they often face…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Runze Cheng , Zhongao Sun , Ye Zhang , Chun Li

Medical imaging segmentation is a highly active area of research, with deep learning-based methods achieving state-of-the-art results in several benchmarks. However, the lack of standardized tools for training, testing, and evaluating new…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Adrian Celaya , Evan Lim , Rachel Glenn , Brayden Mi , Alex Balsells , Dawid Schellingerhout , Tucker Netherton , Caroline Chung , Beatrice Riviere , David Fuentes

Brain metastasis segmentation poses a significant challenge in medical imaging due to the complex presentation and variability in size and location of metastases. In this study, we first investigate the impact of different imaging…

Image and Video Processing · Electrical Eng. & Systems 2024-07-22 Yousef Sadegheih , Dorit Merhof

Medical image segmentation aims to identify anatomical structures at the voxel-level. Segmentation accuracy relies on distinguishing voxel differences. Compared to advancements achieved in studies of the inter-class variance, the…

Image and Video Processing · Electrical Eng. & Systems 2025-03-19 Yali Bi , Enyu Che , Yinan Chen , Yuanpeng He , Jingwei Qu

Cell segmentation is a major bottleneck in extracting quantitative single-cell information from microscopy data. The challenge is exasperated in the setting of microstructured environments. While deep learning approaches have proven useful…

Quantitative Methods · Quantitative Biology 2021-01-08 Tim Prangemeier , Christian Wildner , André O. Françani , Christoph Reich , Heinz Koeppl

Deep learning models have shown promising performance for cell nucleus segmentation in the field of pathology image analysis. However, training a robust model from multiple domains remains a great challenge for cell nucleus segmentation.…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Dawei Fan , Yifan Gao , Jiaming Yu , Yanping Chen , Wencheng Li , Chuancong Lin , Kaibin Li , Changcai Yang , Riqing Chen , Lifang Wei

Studying the growth and metabolism of microbes provides critical insights into their evolutionary adaptations to harsh environments, which are essential for microbial research and biotechnology applications. In this study, we developed an…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Shuang Zhang , Carleton Coffin , Karyn L. Rogers , Catherine Ann Royer , Ge Wang

We introduce a deep learning image segmentation framework that is extremely robust to missing imaging modalities. Instead of attempting to impute or synthesize missing data, the proposed approach learns, for each modality, an embedding of…

Computer Vision and Pattern Recognition · Computer Science 2016-07-19 Mohammad Havaei , Nicolas Guizard , Nicolas Chapados , Yoshua Bengio

Cell nuclei segmentation is one of the most important tasks in the analysis of biomedical images. With ever-growing sizes and amounts of three-dimensional images to be processed, there is a need for better and faster segmentation methods.…

Computer Vision and Pattern Recognition · Computer Science 2017-02-20 Julian Arz , Peter Sanders , Johannes Stegmaier , Ralf Mikut

Deep learning has revolutionized medical and biological imaging, particularly in segmentation tasks. However, segmenting biological cells remains challenging due to the high variability and complexity of cell shapes. Addressing this…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Tianhao Zhang , Heather J. McCourty , Berardo M. Sanchez-Tafolla , Anton Nikolaev , Lyudmila S. Mihaylova

Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Simon Gutwein , Daria Lazic , Thomas Walter , Sabine Taschner-Mandl , Roxane Licandro

Brain tumor segmentation is often based on multiple magnetic resonance imaging (MRI). However, in clinical practice, certain modalities of MRI may be missing, which presents a more difficult scenario. To cope with this challenge, Knowledge…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Tianyi Liu , Zhaorui Tan , Muyin Chen , Xi Yang , Haochuan Jiang , Kaizhu Huang

Despite the remarkable performance of deep learning methods on various tasks, most cutting-edge models rely heavily on large-scale annotated training examples, which are often unavailable for clinical and health care tasks. The labeling…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 Jialin Peng , Ye Wang

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

Automatic cell segmentation in microscopy images works well with the support of deep neural networks trained with full supervision. Collecting and annotating images, though, is not a sustainable solution for every new microscopy database…

Computer Vision and Pattern Recognition · Computer Science 2020-07-06 Youssef Dawoud , Julia Hornauer , Gustavo Carneiro , Vasileios Belagiannis

Pixel-wise segmentation is one of the most data and annotation hungry tasks in our field. Providing representative and accurate annotations is often mission-critical especially for challenging medical applications. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2021-04-28 Simon Reiß , Constantin Seibold , Alexander Freytag , Erik Rodner , Rainer Stiefelhagen

Magnetic resonance (MR) protocols rely on several sequences to assess pathology and organ status properly. Despite advances in image analysis, we tend to treat each sequence, here termed modality, in isolation. Taking advantage of the…

Computer Vision and Pattern Recognition · Computer Science 2020-11-11 Agisilaos Chartsias , Giorgos Papanastasiou , Chengjia Wang , Scott Semple , David E. Newby , Rohan Dharmakumar , Sotirios A. Tsaftaris