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Evaluation of clinical prediction models across multiple clusters, whether centers or datasets, is becoming increasingly common. A comprehensive evaluation includes an assessment of the agreement between the estimated risks and the observed…

Methodology · Statistics 2026-04-22 Lasai Barreñada , Bavo D. C. Campo , Laure Wynants , Ben Van Calster

In recent years, recommender systems have advanced rapidly, where embedding learning for users and items plays a critical role. A standard method learns a unique embedding vector for each user and item. However, such a method has two…

Artificial Intelligence · Computer Science 2023-02-13 Yizhou Chen , Guangda Huzhang , Anxiang Zeng , Qingtao Yu , Hui Sun , Heng-yi Li , Jingyi Li , Yabo Ni , Han Yu , Zhiming Zhou

Spectral clustering, as a popular tool for data clustering, requires an eigen-decomposition step on a given affinity to obtain the spectral embedding. Nevertheless, such a step suffers from the lack of generalizability and scalability.…

Machine Learning · Computer Science 2025-03-13 Wei He , Shangzhi Zhang , Chun-Guang Li , Xianbiao Qi , Rong Xiao , Jun Guo

A recent trend in machine learning has been to enrich learned models with the ability to explain their own predictions. The emerging field of Explainable AI (XAI) has so far mainly focused on supervised learning, in particular, deep neural…

Machine Learning · Computer Science 2022-07-13 Jacob Kauffmann , Malte Esders , Lukas Ruff , Grégoire Montavon , Wojciech Samek , Klaus-Robert Müller

Cluster-level dynamic treatment regimens can be used to guide sequential, intervention or treatment decision-making at the cluster level in order to improve outcomes at the individual or patient-level. In a cluster-level DTR, the…

Methodology · Statistics 2016-07-15 Timothy NeCamp , Amy Kilbourne , Daniel Almirall

The proliferation of high-dimensional data from sources such as social media, sensor networks, and online platforms has created new challenges for clustering algorithms. Multi-view clustering, which integrates complementary information from…

Machine Learning · Computer Science 2026-01-23 Chakib Fettal , Lazhar Labiod , Mohamed Nadif

Mass spectrometry-based proteomics is a key enabler for personalized healthcare, providing a deep dive into the complex protein compositions of biological systems. This technology has vast applications in biotechnology and biomedicine but…

Quantitative Methods · Quantitative Biology 2023-11-23 Sumukh Pinge , Weihong Xu , Jaeyoung Kang , Tianqi Zhang , Neima Moshiri , Wout Bittremieux , Tajana Rosing

In this paper we present a method for the unsupervised clustering of high-dimensional binary data, with a special focus on electronic healthcare records. We present a robust and efficient heuristic to face this problem using tensor…

Machine Learning · Statistics 2017-08-31 Matteo Ruffini , Ricard Gavaldà , Esther Limón

Healthcare datasets often contain groups of highly correlated features, such as features from the same biological system. When feature selection is applied to these datasets to identify the most important features, the biases inherent in…

Machine Learning · Computer Science 2022-07-07 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Multimodal deep learning harnesses diverse imaging modalities, such as MRI sequences, to enhance diagnostic accuracy in medical imaging. A key challenge is determining the optimal timing for integrating these modalities-specifically,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Valerio Guarrasi , Klara Mogensen , Sara Tassinari , Sara Qvarlander , Paolo Soda

Model-based clustering is widely used for identifying and distinguishing types of diseases. However, modern biomedical data coming with high dimensions make it challenging to perform the model estimation in traditional cluster analysis. The…

Methodology · Statistics 2025-07-22 Kazeem Kareem , Fan Dai

Cancer is a number of related yet highly heterogeneous diseases. Correct identification of cancer subtypes is critical for clinical decisions. The advance in sequencing technologies has made it possible to study cancer based on abundant…

Applications · Statistics 2018-11-27 Xiaochun Chen , Honggang Wang , Donghui Yan

Heterogeneous, interconnected, systems-level, molecular data have become increasingly available and key in precision medicine. We need to utilize them to better stratify patients into risk groups, discover new biomarkers and targets,…

Other Quantitative Biology · Quantitative Biology 2024-05-17 Natasa Przulj , Noel Malod-Dognin

We study the problem of clustering networks whose nodes have imputed or physical positions in a single dimension, for example prestige hierarchies or the similarity dimension of hyperbolic embeddings. Existing algorithms, such as the…

Social and Information Networks · Computer Science 2023-12-12 Alice Patania , Antoine Allard , Jean-Gabriel Young

Dimensionality reduction methods are employed to decrease data dimensionality, either to enhance machine learning performance or to facilitate data visualization in two or three-dimensional spaces. These methods typically fall into two…

Machine Learning · Computer Science 2025-08-26 Berat Dogan

This paper studies the subspace clustering problem in which data points collected from high-dimensional ambient space lie in a union of linear subspaces. Subspace clustering becomes challenging when the dimension of intersection between…

Machine Learning · Computer Science 2021-08-17 Weiwei Li , Mostafa Rahmani , Ping Li

Despite tremendous advancements in Artificial Intelligence, learning from large sets of data in an unsupervised manner remains a significant challenge. Classical clustering algorithms often fail to discover complex dependencies in large…

Machine Learning · Computer Science 2023-07-18 Adam Piróg , Halina Kwaśnicka

Multimodal fusion frameworks, which integrate diverse medical imaging modalities (e.g., MRI, CT), have shown great potential in applications such as skin cancer detection, dementia diagnosis, and brain tumor prediction. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-19 J. Dhar , M. K. Pandey , D. Chakladar , M. Haghighat , A. Alavi , S. Mistry , N. Zaidi

Medical images acquired from standardized protocols show consistent macroscopic or microscopic anatomical structures, and these structures consist of composable/decomposable organs and tissues, but existing self-supervised learning (SSL)…

Computer Vision and Pattern Recognition · Computer Science 2025-01-20 Ziyu Zhou , Haozhe Luo , Mohammad Reza Hosseinzadeh Taher , Jiaxuan Pang , Xiaowei Ding , Michael Gotway , Jianming Liang

Clustering is one of the most universal approaches for understanding complex data. A pivotal aspect of clustering analysis is quantitatively comparing clusterings; clustering comparison is the basis for many tasks such as clustering…

Machine Learning · Statistics 2019-06-13 Alexander J. Gates , Ian B. Wood , William P. Hetrick , Yong-Yeol Ahn
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