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Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modified proteome. Standard database search algorithms suffer from…
This article introduces a novel methodology for the massive parallelization of projection-based depths, addressing the computational challenges of data depth in high-dimensional spaces. We propose an algorithmic framework based on Refined…
Text-image alignment constitutes a foundational challenge in multimedia content understanding, where effective modeling of cross-modal semantic correspondences critically enhances retrieval system performance through joint embedding space…
Crosslinking Mass Spectrometry (MS) can uncover protein-protein interactions and provide structural information on proteins in their native cellular environments. Despite its promise, the field remains hampered by inconsistent data formats,…
Most research on novel techniques for 3D Medical Image Segmentation (MIS) is currently done using Deep Learning with GPU accelerators. The principal challenge of such technique is that a single input can easily cope computing resources, and…
Small-molecule identification from tandem mass spectrometry (MS/MS) remains a bottleneck in untargeted settings where spectral libraries are incomplete. While deep learning offers a solution, current approaches typically fall into two…
The Increasing Population Covariance Matrix Adaptation Evolution Strategy (IPOP-CMA-ES) algorithm is a reference stochastic optimizer dedicated to blackbox optimization, where no prior knowledge about the underlying problem structure is…
Machine Learning (ML) alleviates the challenges of high-dimensional data analysis and improves decision making in critical applications like healthcare. Effective cancer type from high-dimensional genetic mutation data can be useful for…
Multi-objective optimization is a crucial matter in computer systems design space exploration because real-world applications often rely on a trade-off between several objectives. Derivatives are usually not available or impractical to…
The digital age has completely transformed the way that information is processed and stored, which makes cybersecurity a crucial field of research. Cybersecurity contains many different domains, but this work focuses on Intrusion Detection…
The combined algorithm selection and hyperparameter tuning (CASH) problem is characterized by large hierarchical hyperparameter spaces. Model-free hyperparameter tuning methods can explore such large spaces efficiently since they are highly…
While deep learning excels in natural image and language processing, its application to high-dimensional data faces computational challenges due to the dimensionality curse. Current large-scale data tools focus on business-oriented…
Similarity-preserving hashing is a widely-used method for nearest neighbour search in large-scale image retrieval tasks. There has been considerable research on generating efficient image representation via the deep-network-based hashing…
Exact Maximum Inner Product Search (MIPS) is an important task that is widely pertinent to recommender systems and high-dimensional similarity search. The brute-force approach to solving exact MIPS is computationally expensive, thus…
Most current sampling algorithms for high-dimensional distributions are based on MCMC techniques and are approximate in the sense that they are valid only asymptotically. Rejection sampling, on the other hand, produces valid samples, but is…
We present a method to search for a probe (or query) image representation against a large gallery in the encrypted domain. We require that the probe and gallery images be represented in terms of a fixed-length representation, which is…
Similarity search in math is to find mathematical expressions that are similar to a user's query. We conceptualized the similarity factors between mathematical expressions, and proposed an approach to math similarity search (MSS) by…
Diversity optimization seeks to discover a set of solutions that elicit diverse features. Prior work has proposed Novelty Search (NS), which, given a current set of solutions, seeks to expand the set by finding points in areas of low…
As an important application of spatial databases in pathology imaging analysis, cross-comparing the spatial boundaries of a huge amount of segmented micro-anatomic objects demands extremely data- and compute-intensive operations, requiring…
Optunity is a free software package dedicated to hyperparameter optimization. It contains various types of solvers, ranging from undirected methods to direct search, particle swarm and evolutionary optimization. The design focuses on ease…