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Fisher's fundamental theorem of natural selection states that the rate of change in a population's mean fitness equals its additive genetic variance in fitness. This implies that mean fitness should not decline in a constant environment,…

Populations and Evolution · Quantitative Biology 2025-08-18 Yun-Yun Yu , Cang Hui , Tian-Jiao Feng , Cong Li , Chao Wang , Yi Tao , Rui-Wu Wang

The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way…

Populations and Evolution · Quantitative Biology 2007-05-23 Niko Beerenwinkel , Lior Pachter , Bernd Sturmfels

Genotypic fitness landscapes are constructed by assessing the fitness of all possible combinations of a given number of mutations. In the last years, several experimental fitness landscapes have been completely resolved. As fitness…

Populations and Evolution · Quantitative Biology 2015-07-02 Luca Ferretti , Daniel Weinreich , Benjamin Schmiegelt , Atsushi Yamauchi , Yutaka Kobayashi , Fumio Tajima , Guillaume Achaz

Most theories of evolutionary diversification are based on equilibrium assumptions: they are either based on optimality arguments involving static fitness landscapes, or they assume that populations first evolve to an equilibrium state…

Populations and Evolution · Quantitative Biology 2017-02-07 Iaroslav Ispolatov , Vaibhav Madhok , Michael Doebeli

Evolutionary dynamics can be studied in well-mixed or structured populations. Population structure typically arises from the heterogeneous distribution of individuals in physical space or on social networks. Here we introduce a new type of…

Populations and Evolution · Quantitative Biology 2009-06-04 Tibor Antal , Hisashi Ohtsuki , John Wakeley , Peter D. Taylor , Martin A. Nowak

For two genotypes that have the same mean number of offspring but differ in the variance in offspring number, natural selection will favor the genotype with lower variance. The concept of fitness becomes cloudy under these conditions…

Populations and Evolution · Quantitative Biology 2007-05-23 Max Shpak , Stephen Proulx

Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…

Populations and Evolution · Quantitative Biology 2018-04-23 Richard A. Neher , Aleksandra M. Walczak

Both evolution and ecology have long been concerned with the impact of variable environmental conditions on observed levels of genetic diversity within and between species. We model the evolution of a quantitative trait under selection that…

Populations and Evolution · Quantitative Biology 2014-11-17 Hannes Svardal , Claus Rueffler , Joachim Hermisson

Evolutionary success depends on the capacity to adapt: organisms must respond to environmental challenges through both genetic innovation and lifetime learning. The gene-centric paradigm attributes evolutionary causality exclusively to…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Nam H. Le

Mitochondrial and nuclear genomes must be co-adapted to ensure proper cellular respiration and energy production. Mito-nuclear incompatibility reduces individual fitness and induces hybrid infertility, suggesting a possible role in…

Populations and Evolution · Quantitative Biology 2022-10-12 Débora Princepe , Marcus A. M. de Aguiar , Joshua B. Plotkin

An equation describing the evolution of phenotypic distribution is derived using methods developed in statistical physics. The equation is solved by using the singular perturbation method, and assuming that the number of bases in the…

Populations and Evolution · Quantitative Biology 2009-11-13 Katsuhiko Sato , Kunihiko Kaneko

Selection in a time-periodic environment is modeled via the two-player replicator dynamics. For sufficiently fast environmental changes, this is reduced to a multi-player replicator dynamics in a constant environment. The two-player terms…

Populations and Evolution · Quantitative Biology 2015-05-13 Armen E. Allahverdyan , Chin-Kun Hu

In the context of global warming, tree populations rely on two primary mechanisms of adaptation: phenotypic plasticity, which enables individuals to adjust their behavior in response to environmental stress, and genetic evolution, driven by…

Populations and Evolution · Quantitative Biology 2026-01-27 Sirine Boucenna , Vasilis Dakos , Gaël Raoul

Evolution is the process of optimal adaptation of biological populations to their living environments. This is expressed via the concept of fitness, defined as relative reproductive success. However, it has been pointed out that this…

Populations and Evolution · Quantitative Biology 2025-04-17 Luís MA Bettencourt , Brandon J Grandison , Jordan T Kemp

Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should, as John Maynard Smith famously pointed out,…

Populations and Evolution · Quantitative Biology 2016-03-08 Sam F. Greenbury , Steffen Schaper , Sebastian E. Ahnert , Ard A. Louis

In this paper, we discuss the fitness landscape evolution of permanent replicator systems using a hypothesis that the specific time of evolutionary adaptation of the system parameters is much slower than the time of internal evolutionary…

Populations and Evolution · Quantitative Biology 2019-11-11 Sergei Drozhzhin , Tatiana Yakushkina , Alexander Bratus

Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a microbial population exposed to varied antibiotics, constantly search for adaptive solutions in time-varying fitness landscapes. Generalists correspond to…

Biological Physics · Physics 2020-07-01 Shenshen Wang , Lei Dai

The concept of fitness as a measure for a species's success in natural selection is central to the theory of evolution. We here investigate how reproduction rates which are not constant but vary in response to environmental fluctuations,…

Populations and Evolution · Quantitative Biology 2015-10-21 Anna Melbinger , Massimo Vergassola

We study a stochastic predator-prey model on a square lattice, where each of the six species has two superior and two inferior partners. The invasion probabilities between species depend on the predator-prey pair and are supplemented by…

Populations and Evolution · Quantitative Biology 2007-08-25 Matjaz Perc , Attila Szolnoki

Evolution depends on the fitness of organisms, the expected rate of reproducing. Directly getting offspring is the most basic form of fitness, but fitness can also be increased indirectly by helping genetically related individuals (such as…

Populations and Evolution · Quantitative Biology 2015-12-17 J. H. van Hateren
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