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Although Alzheimer's disease (AD) cannot be reversed or cured, timely diagnosis can significantly reduce the burden of treatment and care. Current research on AD diagnosis models usually regards the diagnosis task as a typical…

In this paper, we propose a new deep framework which predicts facial attributes and leverage it as a soft modality to improve face identification performance. Our model is an end to end framework which consists of a convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2018-05-02 Fariborz Taherkhani , Nasser M. Nasrabadi , Jeremy Dawson

Healthcare datasets present many challenges to both machine learning and statistics as their data are typically heterogeneous, censored, high-dimensional and have missing information. Feature selection is often used to identify the…

Machine Learning · Computer Science 2022-07-06 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Imaging and genomic data offer distinct and rich features, and their integration can unveil new insights into the complex landscape of diseases. In this study, we present a novel approach utilizing radiogenomic data including structural MRI…

Machine Learning · Computer Science 2025-05-16 Aditya Raj , Golrokh Mirzaei

We propose a novel framework for Alzheimer's disease (AD) detection using brain MRIs. The framework starts with a data augmentation method called Brain-Aware Replacements (BAR), which leverages a standard brain parcellation to replace…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mehmet Saygın Seyfioğlu , Zixuan Liu , Pranav Kamath , Sadjyot Gangolli , Sheng Wang , Thomas Grabowski , Linda Shapiro

Characterizing the subtle changes of functional brain networks associated with the pathological cascade of Alzheimer's disease (AD) is important for early diagnosis and prediction of disease progression prior to clinical symptoms. We…

Neurons and Cognition · Quantitative Biology 2020-11-12 Mengjia Xu , David Lopez Sanz , Pilar Garces , Fernando Maestu , Quanzheng Li , Dimitrios Pantazis

Progressive cognitive decline spanning across decades is characteristic of Alzheimer's disease (AD). Various predictive models have been designed to realize its early onset and study the long-term trajectories of cognitive test scores…

Alzheimer's Disease is challenging to diagnose due to our limited understanding of its mechanism and large heterogeneity among patients. Neurodegeneration is studied widely as a biomarker for clinical diagnosis, which can be measured from…

Machine Learning · Computer Science 2024-10-18 Rosemary He , Ichiro Takeuchi

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia. Structural MRI is widely used to analyze AD-related brain atrophy; however, most deep learning methods rely on computationally expensive 3D…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Towhidul Islam , Mufti Mahmud

Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…

Computation and Language · Computer Science 2019-06-14 Flavio Di Palo , Natalie Parde

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…

Unveiling pathological brain changes associated with Alzheimer's disease (AD) is a challenging task especially that people do not show symptoms of dementia until it is late. Over the past years, neuroimaging techniques paved the way for…

Quantitative Methods · Quantitative Biology 2018-08-07 Mayssa Soussia , Islem Rekik

Predicting conversion from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) is critical for early intervention. Current deep learning paradigms predominantly rely on cross-sectional structural MRI, neglecting prognostic value in…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Alireza Moayedikia , Sara Fin , Alicia Troncoso Lora , Uffe Kock Wiil

Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological…

Machine Learning · Computer Science 2023-04-20 Nair Bini Balakrishnan , P. S. Sreeja , Jisha Jose Panackal

Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Alzheimer's disease (AD) is the leading cause of dementia, and its early detection is crucial for effective intervention, yet current diagnostic methods often fall short in sensitivity and specificity. This study aims to detect significant…

Image and Video Processing · Electrical Eng. & Systems 2024-11-01 Milla E. Nielsen , Mads Nielsen , Mostafa Mehdipour Ghazi

Early detection of Alzheimer's disease's precursor stages is imperative for significantly enhancing patient outcomes and quality of life. This challenge is tackled through a semi-supervised multi-modal diagnosis framework. In particular, we…

Machine Learning · Computer Science 2024-03-20 Angelica I. Aviles-Rivero , Chun-Wun Cheng , Zhongying Deng , Zoe Kourtzi , Carola-Bibiane Schönlieb

The ABCD Neurocognitive Prediction Challenge is a community driven competition asking competitors to develop algorithms to predict fluid intelligence score from T1-w MRIs. In this work, we propose a deep learning combined with gradient…

Computer Vision and Pattern Recognition · Computer Science 2019-10-18 Yeeleng S. Vang , Yingxin Cao , Xiaohui Xie

To achieve effective and efficient detection of Alzheimer's disease (AD), many machine learning methods have been introduced into this realm. However, the general case of limited training samples, as well as different feature…

Machine Learning · Computer Science 2013-10-04 Fayao Liu , Luping Zhou , Chunhua Shen , Jianping Yin

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran