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Enantiodetection of chiral molecules is important to pharmaceutical drug production, chemical reaction control, and biological function designs. Traditional optical methods of enantiodetection rely on the weak magnetic-dipole or…

Chemical Physics · Physics 2022-09-14 Mao-Rui Cai , Chong Ye , Hui Dong , Yong Li

Developing effective methods to measure the enantiomeric excess of the chiral mixture is one of the major topics in chiral molecular researches, yet remains challenging. Enantiodetection method via two-dimensional (2D) spectroscopy based on…

Chemical Physics · Physics 2023-05-05 Mao-Rui Cai , Chong Ye , Yong Li , Hui Dong

Distinguishing between enantiomers is crucial in the study of chiral molecules in chemistry and pharmacology. Many optical approaches rely on enantiospecific cyclic electric-dipole transitions induced by three microwave or laser beams.…

Quantum Physics · Physics 2025-12-11 Fen Zou , Yong Li , Peng Zhang

We propose a theoretical method for enantio-discrimination based on the light deflection effect in four-level models of chiral molecules. This four-level model consists of a cyclic three-level subsystem coupled by three strong driving…

Optics · Physics 2020-08-12 Yu-Yuan Chen , Chong Ye , Quansheng Zhang , Yong Li

Enantio-conversion with the help of electromagnetic fields is an essential issue due to the chirality-dependence of many chemical, biological, and pharmaceutical processes. Here, we propose a method for this issue based on a five-level…

Quantum Physics · Physics 2021-03-03 Chong Ye , Bo Liu , Yu-Yuan Chen , Yong Li

Chiroptical effects using circularly polarized light produce signals that change sign when switching either molecular handedness (enantiosensitivity) or the light helicity (circular dichroism). Here, we break this…

Enantioselective photochemistry provides access to unique molecular structures and functions, with deep implications for fundamental science and industrial applications. Current methods for highly enantioselective photochemistry critically…

Chemical Physics · Physics 2025-03-07 Andrés Ordóñez , Patricia Vindel-Zandbergen , David Ayuso

We investigate enantiodetection for both a single cyclic three-level chiral molecule and finite ensembles of such molecules by monitoring the steady-state intracavity photon number in a cavity-QED platform. Our scheme exploits the intrinsic…

Quantum Physics · Physics 2025-11-14 Xiang Guo , Xiaojun Zhang , Yong Li , Zhihai Wang

We propose a gain-assisted enantioselective scheme in dye-doped chiral particles, demonstrating optical pulling and pushing forces that can be tuned using externally controllable parameters. By controlling the concentration of dye molecules…

We present an optical "enantio-selective switch", that, in two steps, turns a ("racemic") mixture of left-handed and right-handed chiral molecules into the enantiomerically pure state of interest. The optical switch is composed of an…

Quantum Physics · Physics 2009-11-07 Petr Král , Ioannis Thanopulos , Moshe Shapiro , Doron Cohen

We show that the position of the exceptional points (EPs) in the parameter space of a chiral molecule coupled to the photoionization continuum by a three-color field is enantiosensitive. Using a minimal model of a three-level system driven…

Quantum Physics · Physics 2023-07-11 Nicola Mayer , Nimrod Moiseyev , Olga Smirnova

Determination of enantiomeric excess is important and remains challenges. We theoretically propose a new spectroscopic method for this issue based on the chirality-dependent AC Stark effects in cyclic three-level models under the…

Optics · Physics 2019-09-17 Chong Ye , Quansheng Zhang , Yu-Yuan Chen , Yong Li

The topological response of matter to electromagnetic fields is a property in high demand in materials design and metrology due to its robustness against noise and decoherence, stimulating recent advances in ultrafast photonics. Embedding…

We propose an enantio-detection method of chiral molecules in a cavity with external drive. The chiral molecules are coupled with a quantized cavity field and two classical light fields to form the cyclic three-level systems. The…

Quantum Physics · Physics 2022-02-15 Yu-Yuan Chen , Jian-Jian Cheng , Chong Ye , Yong Li

Today we are witnessing the electric-dipole revolution in chiral measurements. Here we reflect on its lessons and outcomes, such as the perspective on chiral measurements using the complementary principles of "chiral reagent" and "chiral…

Optics · Physics 2022-11-30 David Ayuso , Andres F. Ordonez , Olga Smirnova

We propose a method to realize enantiodiscrimination of chiral molecules based on quantum correlation function in a driven cavity-molecule system, where the chiral molecule is coupled with a quantized cavity field and two classical light…

Quantum Physics · Physics 2022-08-12 Fen Zou , Yu-Yuan Chen , Bo Liu , Yong Li

Chiral discrimination that is efficient to tiny amounts of chiral substances, especially at the single-molecule level, is highly demanded. Here, we propose a single-shot nondestructive quantum sensing method addressing such an issue. Our…

Quantum Physics · Physics 2023-10-05 Chong Ye , Yifan Sun , Yong Li , Xiangdong Zhang

Detecting and controlling the chirality of materials play an essential role in exploring nature, providing new avenues for material creation, discrimination, and manipulation. In such tasks, chiral reagents are essential in defining or…

Chiroptical enantioselective sensing is gaining traction across various applications. However, intrinsic molecular chiroptical responses are weak, and existing amplification approaches add synthesis, manufacturing, or operational complexity…

We propose to discriminate chiral molecules by combining one- and two-photon processes in a closed-loop configuration. The one-photon-coupling intrinsic {\pi}-phase difference between two enantiomers leads to their different superposition…

Quantum Physics · Physics 2020-02-20 Jin-Lei Wu , Yan Wang , Jie Song , Yan Xia , Shi-Lei Su , Yong-Yuan Jiang
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