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We consider a bilinear optimal control problem associated to the following chemotaxis-consumption model in a bounded domain $\Omega \subset \mathbb{R}^3$ during a time interval $(0,T)$: $$\partial_t u - \Delta u = - \nabla \cdot (u \nabla…

Optimization and Control · Mathematics 2023-10-26 Francisco Guillén-González , André Luiz Corrêa Vianna Filho

In the present review we focus on the chemotaxis-consumption model $\partial_t u - \Delta u = - \nabla \cdot (u \nabla v)$ and $\partial_t v - \Delta v = - u^s v$ in $(0,T) \times \Omega$, for any fixed $s \geq 1$, endowed with isolated…

Analysis of PDEs · Mathematics 2024-02-12 André Luiz Corrêa Vianna Filho , Francisco Guillén-González

The chemotaxis system \begin{align*} u_t &= \Delta u - \nabla \cdot (u\nabla v), \\ v_t &= \Delta v - uv, \end{align*} is considered under the boundary conditions $\frac{\partial u}{\partial\nu}- u\frac{\partial v}{\partial\nu}=0$ and…

Analysis of PDEs · Mathematics 2022-01-05 Johannes Lankeit , Michael Winkler

In this paper we study the following three-dimensional parabolic-parabolic chemo-repulsion model with potential production, logistic reaction and bilinear control, defined in $Q=(0,T)\times\Omega$: \begin{equation*}\label{eq0} \left\{…

An optimal control problem associated to the Keller-Segel with logistic reaction system will be studied in $2D$ domains. The control acts in a bilinear form only in the chemical equation. The existence of optimal control and a necessary…

Optimization and Control · Mathematics 2022-07-01 P. Braz e Silva , F. Guillén-González , C. F. Perusato , M. A. Rodríguez-Bellido

We investigate optimal control problems governed by the elliptic partial differential equation $-\Delta u=f$ subject to Dirichlet boundary conditions on a given domain $\Omega$. The control variable in this setting is the right-hand side…

Optimization and Control · Mathematics 2025-09-03 Giuseppe Buttazzo , Juan Casado-Díaz , Faustino Maestre

In this paper, we study an optimal control problem for a coupled non-linear system of reaction-diffusion equations with degenerate diffusion, consisting of two partial differential equations representing the density of cells and the…

Optimization and Control · Mathematics 2024-07-11 Georges Chamoun , Mazen Saad , Toni Sayah , Sarah Serhal

The basic chemotaxis-consumption model \[ u_t = \Delta u - \nabla \cdot(u\nabla v),\qquad\qquad v_t = \Delta v - uv \] is considered in general, possibly non-convex bounded domains of arbitrary spatial dimension. Global existence of weak…

Analysis of PDEs · Mathematics 2025-02-25 Johannes Lankeit , Michael Winkler

In this article, the limiting behavior of the solution $\bar u_s$ of the optimal control problem subjected to the fractional Poisson equation $$(-\Delta)^s u_s(x)=f_s(x), \quad x\in \Omega$$ defined on domain $\Omega$ bounded by smooth…

Numerical Analysis · Mathematics 2025-03-13 Ram Manohar , Kedarnath Buda , B. V. Rathish Kumar

For given total mass $m>0$ we show unique solvability of the stationary chemotaxis-consumption model \[ \begin{cases} 0= \Delta u - \chi \nabla \cdot (\frac{u}{v} \nabla v) \\ 0= \Delta v - uv \\ \int_\Omega u = m \end{cases} \] under…

Analysis of PDEs · Mathematics 2024-06-28 Jaewook Ahn , Johannes Lankeit

A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design…

Analysis of PDEs · Mathematics 2021-03-23 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In this paper we study the zero-flux chemotaxis-system \begin{equation*} \begin{cases} u_t=\Delta u -\chi \nabla \cdot (\frac{u}{v} \nabla v) \\ v_t=\Delta v-f(u)v \end{cases} \end{equation*} in a smooth and bounded domain $\Omega$ of…

Analysis of PDEs · Mathematics 2018-05-24 Johannes Lankeit , Giuseppe Viglialoro

In this work we investigate the following chemo-attraction with consumption model in bounded domains of \, $\mathbb{R}^N$ ($N=1,2,3$): $$ \partial_t u - \Delta u = - \nabla \cdot (u \nabla v), \quad \partial_t v - \Delta v = - u^s v $$…

Analysis of PDEs · Mathematics 2023-02-17 A. L. Corrêa Vianna Filho , Francisco Guillén-González

A class of optimal control problems governed by linear fractional diffusion equation with control constraint is considered. We first establish some results on the existence of strong solution to the state equation and the existence of…

Optimization and Control · Mathematics 2022-11-24 Bui Trong Kien , Bui Ngoc Muoi , Ching-Feng Wen , Jen-Chih Yao

In this paper we consider an optimal control problem arising from a chemotherapeutic drug treatment for tumor cells in a living tissue. The mathematical model for the interaction of chemotherapeutic drug and the normal, tumor and immune…

Analysis of PDEs · Mathematics 2022-12-13 Hong-Ming Yin

In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…

Analysis of PDEs · Mathematics 2023-10-25 Matteo Fornoni

This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we…

Optimization and Control · Mathematics 2023-06-06 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In the present work we propose and study a time discrete scheme for the following chemotaxis-consumption model (for any $s\ge 1$), $$ \partial_t u - \Delta u = - \nabla \cdot (u \nabla v), \quad \partial_t v - \Delta v = - u^s v \quad…

Numerical Analysis · Mathematics 2023-10-26 Francisco Guillén-González , André Luiz Corrêa Vianna Filho

This work deals with the consumption chemotaxis problem \begin{equation*} \begin{cases*} u_t = \Delta u - \chi \nabla \cdot u\nabla v + \lambda u - \mu u^2 - c \lvert \nabla u \rvert^\gamma, & \text{in $\Omega\times(0,\tmax)$}, v_t = \Delta…

Analysis of PDEs · Mathematics 2024-08-27 Alessandro Columbu

Previous studies of chemotaxis models with consumption of the chemoattractant (with or without fluid) have not been successful in explaining pattern formation even in the simplest form of concentration near the boundary, which had been…

Analysis of PDEs · Mathematics 2019-02-05 Marcel Braukhoff , Johannes Lankeit
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