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The versatility of multimodal deep learning holds tremendous promise for advancing scientific research and practical applications. As this field continues to evolve, the collective power of cross-modal analysis promises to drive…

Machine Learning · Computer Science 2025-05-15 Yifei Wang , Yunrui Li , Lin Liu , Pengyu Hong , Hao Xu

Molecular Representation Learning (MRL) has proven impactful in numerous biochemical applications such as drug discovery and enzyme design. While Graph Neural Networks (GNNs) are effective at learning molecular representations from a 2D…

Multimodal knowledge graph completion (MKGC) aims to predict missing entities in MKGs. Previous works usually share relation representation across modalities. This results in mutual interference between modalities during training, since for…

Computation and Language · Computer Science 2022-11-02 Yu Zhao , Xiangrui Cai , Yike Wu , Haiwei Zhang , Ying Zhang , Guoqing Zhao , Ning Jiang

Multimodal dialogue emotion recognition captures emotional cues by fusing text, visual, and audio modalities. However, existing approaches still suffer from notable limitations in modeling emotional dependencies and learning multimodal…

Multimedia · Computer Science 2026-03-12 Yunsheng Wang , Yuntao Shou , Yilong Tan , Wei Ai , Tao Meng , Keqin Li

Learning multimodal representations is a fundamentally complex research problem due to the presence of multiple heterogeneous sources of information. Although the presence of multiple modalities provides additional valuable information,…

Machine Learning · Computer Science 2019-05-15 Yao-Hung Hubert Tsai , Paul Pu Liang , Amir Zadeh , Louis-Philippe Morency , Ruslan Salakhutdinov

Dual embodied-symbolic concept representations are the foundation for deep learning and symbolic AI integration. We discuss the use of dual embodied-symbolic concept representations for molecular graph representation learning, specifically…

Machine Learning · Computer Science 2022-05-16 Daniel T. Chang

Molecular representation learning has shown great success in advancing AI-based drug discovery. The core of many recent works is based on the fact that the 3D geometric structure of molecules provides essential information about their…

Machine Learning · Computer Science 2024-10-23 Jiying Zhang , Zijing Liu , Yu Wang , Yu Li

Recent years have seen a rapid growth of utilizing graph neural networks (GNNs) in the biomedical domain for tackling drug-related problems. However, like any other deep architectures, GNNs are data hungry. While requiring labels in real…

Biological Physics · Physics 2022-05-03 Mengying Sun , Jing Xing , Huijun Wang , Bin Chen , Jiayu Zhou

Deep learning methods have revolutionized speech recognition, image recognition, and natural language processing since 2010. Each of these tasks involves a single modality in their input signals. However, many applications in the artificial…

Artificial Intelligence · Computer Science 2020-07-15 Chao Zhang , Zichao Yang , Xiaodong He , Li Deng

We introduce Functional Group-Aware Representations for Small Molecules (FARM), a novel foundation model designed to bridge the gap between SMILES, natural language, and molecular graphs. The key idea behind FARM is the incorporation of…

Machine Learning · Computer Science 2026-04-29 Thao Nguyen , Kuan-Hao Huang , Ge Liu , Martin D. Burke , Ying Diao , Heng Ji

Automated computational analysis of the vast chemical space is critical for numerous fields of research such as drug discovery and material science. Representation learning techniques have recently been employed with the primary objective…

Quantitative Methods · Quantitative Biology 2023-05-26 Atakan Yüksel , Erva Ulusoy , Atabey Ünlü , Tunca Doğan

In recent years, unsupervised and self-supervised graph representation learning has gained popularity in the research community. However, most proposed methods are focused on homogeneous networks, whereas real-world graphs often contain…

Machine Learning · Computer Science 2024-02-29 Piotr Bielak , Tomasz Kajdanowicz

Recent years have witnessed the resurgence of knowledge engineering which is featured by the fast growth of knowledge graphs. However, most of existing knowledge graphs are represented with pure symbols, which hurts the machine's capability…

Artificial Intelligence · Computer Science 2022-12-20 Xiangru Zhu , Zhixu Li , Xiaodan Wang , Xueyao Jiang , Penglei Sun , Xuwu Wang , Yanghua Xiao , Nicholas Jing Yuan

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

Machine Learning · Computer Science 2026-05-19 Xiaoguang Zhu , Linxiao Gong , Lianlong Sun , Yang Liu , Haoyu Wang , Jing Liu

Medical multimodal representation learning aims to integrate heterogeneous clinical data into unified patient representations to support predictive modeling, which remains an essential yet challenging task in the medical data mining…

Machine Learning · Computer Science 2025-09-09 Xiaoguang Zhu , Lianlong Sun , Yang Liu , Pengyi Jiang , Uma Srivatsa , Nipavan Chiamvimonvat , Vladimir Filkov

Molecule representation learning is crucial for understanding and predicting molecular properties. However, conventional atom-centric models, which treat chemical bonds merely as pairwise interactions, often overlook complex bond-level…

Machine Learning · Computer Science 2026-03-03 Yunqing Liu , Yi Zhou , Wenqi Fan

Recognizing multiple labels of images is a practical and challenging task, and significant progress has been made by searching semantic-aware regions and modeling label dependency. However, current methods cannot locate the semantic regions…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Tianshui Chen , Muxin Xu , Xiaolu Hui , Hefeng Wu , Liang Lin

Accurate molecular property prediction is a critical challenge with wide-ranging applications in chemistry, materials science, and drug discovery. Molecular representation methods, including fingerprints and graph neural networks (GNNs),…

Machine Learning · Computer Science 2025-08-13 Jiaxin Ju , Yizhen Zheng , Huan Yee Koh , Can Wang , Shirui Pan

Multi-omics data analysis has the potential to discover hidden molecular interactions, revealing potential regulatory and/or signal transduction pathways for cellular processes of interest when studying life and disease systems. One of…

Quantitative Methods · Quantitative Biology 2022-03-18 Arman Hasanzadeh , Ehsan Hajiramezanali , Nick Duffield , Xiaoning Qian

Molecular knowledge resides within three different modalities of information sources: molecular structures, biomedical documents, and knowledge bases. Effective incorporation of molecular knowledge from these modalities holds paramount…

Biomolecules · Quantitative Biology 2023-07-24 Yizhen Luo , Kai Yang , Massimo Hong , Xing Yi Liu , Zaiqing Nie