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Quantum chemical calculations of the ground-state properties of positron-molecule complexes are challenging. The main difficulty lies in employing an appropriate basis set for representing the coalescence between electrons and a positron.…

Computational Physics · Physics 2024-02-08 G. Cassella , W. M. C. Foulkes , D. Pfau , J. S. Spencer

Predicting the structure of multi-protein complexes is a grand challenge in biochemistry, with major implications for basic science and drug discovery. Computational structure prediction methods generally leverage pre-defined structural…

Biomolecules · Quantitative Biology 2021-01-26 Stephan Eismann , Raphael J. L. Townshend , Nathaniel Thomas , Milind Jagota , Bowen Jing , Ron O. Dror

High-precision predictions of nuclear properties are a central objective of ab initio nuclear structure theory. However, state-of-the-art many-body methods rely on truncated model spaces to render the nuclear many-body problem tractable,…

Nuclear Theory · Physics 2026-04-10 Marco Knöll

Deep learning has the potential to revolutionize quantum chemistry as it is ideally suited to learn representations for structured data and speed up the exploration of chemical space. While convolutional neural networks have proven to be…

Physicists dating back to Feynman have lamented the difficulties of applying the variational principle to quantum field theories. In non-relativistic quantum field theories, the challenge is to parameterize and optimize over the infinitely…

Quantum Physics · Physics 2024-09-04 John M. Martyn , Khadijeh Najafi , Di Luo

We demonstrate a machine learning approach designed to extract hidden chemistry/physics to facilitate new materials discovery. In particular, we propose a novel method for learning latent knowledge from material structure data in which…

Materials Science · Physics 2021-08-03 Tien-Cuong Nguyen , Van-Quyen Nguyen , Van-Linh Ngo , Quang-Khoat Than , Tien-Lam Pham

In pursuing the essential elements of nuclear binding, we compute ground-state properties of atomic nuclei with up to $A=20$ nucleons, using as input a leading order pionless effective field theory Hamiltonian. A variational Monte Carlo…

Nuclear Theory · Physics 2023-09-01 A. Gnech , B. Fore , A. Lovato

A microscopic description of the interaction of atomic nuclei with external electroweak probes is required for elucidating aspects of short-range nuclear dynamics and for the correct interpretation of neutrino oscillation experiments.…

Neural-network-based machine learning interatomic potentials have emerged as powerful tools for predicting atomic energies and forces, enabling accurate and efficient simulations in atomistic modeling. A key limitation of traditional deep…

Chemical Physics · Physics 2025-09-24 Riccardo Farris , Emanuele Telari , Nongnuch Artrith , Konstantin Neyman , Albert Bruix

High-precision atomic structure calculations require accurate modelling of electronic correlations typically addressed via the configuration interaction (CI) problem on a multiconfiguration wave function expansion. The latter can easily…

Atomic Physics · Physics 2023-06-22 Pavlo Bilous , Adriana Pálffy , Florian Marquardt

The challenge posed by the many-body problem in quantum physics originates from the difficulty of describing the non-trivial correlations encoded in the exponential complexity of the many-body wave function. Here we demonstrate that…

Disordered Systems and Neural Networks · Physics 2017-02-13 Giuseppe Carleo , Matthias Troyer

Simulating strongly correlated fermionic systems remains a fundamental challenge in quantum physics, largely due to the sign problem in quantum Monte Carlo (QMC) methods. We present a neural network-based variational Monte Carlo (NN-VMC)…

Computational Physics · Physics 2025-09-09 William Freitas , B. Abreu , S. A. Vitiello

Neural networks (NNs) have great potential in solving the ground state of various many-body problems. However, several key challenges remain to be overcome before NNs can tackle problems and system sizes inaccessible with more established…

Strongly Correlated Electrons · Physics 2026-02-24 Khachatur Nazaryan , Filippo Gaggioli , Yi Teng , Liang Fu

Deep learning has deeply changed the paradigms of many research fields. At the heart of chemical and physical sciences is the accurate ab initio calculation of many-body wavefunction, which has become one of the most notable examples to…

Chemical Physics · Physics 2025-04-01 Yubing Qian , Xiang Li , Zhe Li , Weiluo Ren , Ji Chen

Metasurfaces have shown promising potentials in shaping optical wavefronts while remaining compact compared to bulky geometric optics devices. Design of meta-atoms, the fundamental building blocks of metasurfaces, relies on trial-and-error…

Deep neural networks have been extremely successful as highly accurate wave function ans\"atze for variational Monte Carlo calculations of molecular ground states. We present an extension of one such ansatz, FermiNet, to calculations of the…

Computational Physics · Physics 2023-02-01 G. Cassella , H. Sutterud , S. Azadi , N. D. Drummond , D. Pfau , J. S. Spencer , W. M. C. Foulkes

Deep artificial neural networks are powerful tools with many possible applications in nanophotonics. Here, we demonstrate how a deep neural network can be used as a fast, general purpose predictor of the full near-field and far-field…

Computational Physics · Physics 2020-01-28 Peter R. Wiecha , Otto L. Muskens

A novel machine learning approach is used to provide further insight into atomic nuclei and to detect orderly patterns amidst a vast data of large-scale calculations. The method utilizes a neural network that is trained on ab initio results…

Nuclear Theory · Physics 2022-03-14 O. M. Molchanov , K. D. Launey , A. Mercenne , G. H. Sargsyan , T. Dytrych , J. P. Draayer

We discuss differences and similarities between variational Monte Carlo approaches that use conventional and artificial neural network parameterizations of the ground-state wave function for systems of fermions. We focus on a relatively…

Mesoscale and Nanoscale Physics · Physics 2025-01-13 Even M. Nordhagen , Jane M. Kim , Bryce Fore , Alessandro Lovato , Morten Hjorth-Jensen

Quantum many-body systems are of great interest for many research areas, including physics, biology and chemistry. However, their simulation is extremely challenging, due to the exponential growth of the Hilbert space with the system size,…

Quantum Physics · Physics 2024-10-23 Lorenzo Brevi , Antonio Mandarino , Enrico Prati