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Cancer is a complex disease characterized by uncontrolled cell growth and proliferation. T cell receptors (TCRs) are essential proteins for the adaptive immune system, and their specific recognition of antigens plays a crucial role in the…

We propose a new methodology for selecting and ranking covariates associated with a variable of interest in a context of high-dimensional data under dependence but few observations. The methodology successively intertwines the clustering of…

The reservoir computing paradigm is employed to classify heartbeat anomalies online based on electrocardiogram signals. Inspired by the principles of information processing in the brain, reservoir computing provides a framework to design,…

Language models can be sampled multiple times to access the distribution underlying their responses, but existing methods cannot efficiently synthesize rich epistemic signals across different long-form responses. We introduce Consensus…

Determining the adsorption isotherms is an issue of significant importance in preparative chromatography. A modern technique for estimating adsorption isotherms is to solve an inverse problem so that the simulated batch separation coincides…

This paper discusses distributed approaches for the solution of random convex programs (RCP). RCPs are convex optimization problems with a (usually large) number N of randomly extracted constraints; they arise in several applicative areas,…

This paper presents a novel sampling scheme for masked non-autoregressive generative modeling. We identify the limitations of TimeVQVAE, MaskGIT, and Token-Critic in their sampling processes, and propose Enhanced Sampling Scheme (ESS) to…

Waveform signal analysis is a complex and important task in medical care. For example, mechanical ventilators are critical life-support machines, but they can cause serious injury to patients if they are out of synchronization with the…

We consider offline detection of a single changepoint in binary and count time-series. We compare exact tests based on the cumulative sum (CUSUM) and the likelihood ratio (LR) statistics, and a new proposal that combines exact two-sample…

In this paper, we consider the patient similarity matching problem over a cancer cohort of more than 220,000 patients. Our approach first leverages on Word2Vec framework to embed ICD codes into vector-valued representation. We then propose…

Despite remarkable performance in producing realistic samples, Generative Adversarial Networks (GANs) often produce low-quality samples near low-density regions of the data manifold, e.g., samples of minor groups. Many techniques have been…

The need to estimate a particular quantile of a distribution is an important problem which frequently arises in many computer vision and signal processing applications. For example, our work was motivated by the requirements of many…

Overconfidence in deep learning models poses a significant risk in high-stakes medical imaging tasks, particularly in multi-label classification of chest X-rays, where multiple co-occurring pathologies must be detected simultaneously. This…

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted…

Motivated by the inquiries of weak signals in underpowered genome-wide association studies (GWASs), we consider the problem of retaining true signals that are not strong enough to be individually separable from a large amount of noise. We…

Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive)and type II (false negative) errors. In this work, we develop a statistical model to study how medical…

An important paradigm in smart health is developing diagnosis tools and monitoring a patient's heart activity through processing Electrocardiogram (ECG) signals is a key example, sue to high mortality rate of heart-related disease. However,…

This paper studies graph-based active learning, where the goal is to reconstruct a binary signal defined on the nodes of a weighted graph, by sampling it on a small subset of the nodes. A new sampling algorithm is proposed, which…

In a typical Event-Based Surveillance setting, a stream of web documents is continuously monitored for disease reporting. A structured representation of the disease reporting events is extracted from the raw text, and the events are then…