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Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data…

Machine Learning · Computer Science 2025-11-21 Perrine Chassat , Van Tuan Nguyen , Lucas Ducrot , Emilie Lanoy , Agathe Guilloux

The widespread adoption of wearable sensors has the potential to provide massive and heterogeneous time series data, driving the use of Artificial Intelligence in human sensing applications. However, data collection remains limited due to…

Machine Learning · Computer Science 2025-12-04 Flavio Di Martino , Franca Delmastro

Data generation is a fundamental research problem in data management due to its diverse use cases, ranging from testing database engines to data-specific applications. However, real-world entities often involve complex interactions that…

Databases · Computer Science 2024-12-13 Fan Li , Xiaoyang Wang , Dawei Cheng , Cong Chen , Ying Zhang , Xuemin Lin

One of the impediments in advancing actuarial research and developing open source assets for insurance analytics is the lack of realistic publicly available datasets. In this work, we develop a workflow for synthesizing insurance datasets…

Applications · Statistics 2020-08-07 Kevin Kuo

Recent deep generative models (DGMs) such as generative adversarial networks (GANs) and diffusion probabilistic models (DPMs) have shown their impressive ability in generating high-fidelity photorealistic images. Although looking appealing…

Computer Vision and Pattern Recognition · Computer Science 2023-11-09 Ruyu Wang , Sabrina Schmedding , Marco F. Huber

Deep generative modeling has emerged as a powerful tool for synthesizing realistic medical images, driving advances in medical image analysis, disease diagnosis, and treatment planning. This chapter explores various deep generative models…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Paul Friedrich , Yannik Frisch , Philippe C. Cattin

Accurately forecasting extreme rainfall is notoriously difficult, but is also ever more crucial for society as climate change increases the frequency of such extremes. Global numerical weather prediction models often fail to capture…

Machine Learning · Statistics 2022-03-24 Ilan Price , Stephan Rasp

Generative models such as the variational autoencoder (VAE) and the generative adversarial networks (GAN) have proven to be incredibly powerful for the generation of synthetic data that preserves statistical properties and utility of…

Signal Processing · Electrical Eng. & Systems 2022-04-29 Moustafa Alzantot , Luis Garcia , Mani Srivastava

Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

Modeling the probability distribution of rows in tabular data and generating realistic synthetic data is a non-trivial task. Tabular data usually contains a mix of discrete and continuous columns. Continuous columns may have multiple modes…

Machine Learning · Computer Science 2019-10-29 Lei Xu , Maria Skoularidou , Alfredo Cuesta-Infante , Kalyan Veeramachaneni

Mobility datasets are fundamental for evaluating algorithms pertaining to geographic information systems and facilitating experimental reproducibility. But privacy implications restrict sharing such datasets, as even aggregated…

Machine Learning · Computer Science 2018-12-03 Vaibhav Kulkarni , Natasa Tagasovska , Thibault Vatter , Benoit Garbinato

In recent years, deep learning based generative models, particularly Generative Adversarial Networks (GANs), Variational Autoencoders (VAEs), and Diffusion Models (DMs), have been instrumental in in generating diverse, high-quality content…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Shamim Yazdani , Akansha Singh , Nripsuta Saxena , Zichong Wang , Avash Palikhe , Deng Pan , Umapada Pal , Jie Yang , Wenbin Zhang

Despite continuous improvements, precipitation forecasts are still not as accurate and reliable as those of other meteorological variables. A major contributing factor to this is that several key processes affecting precipitation…

Atmospheric and Oceanic Physics · Physics 2022-11-09 Lucy Harris , Andrew T. T. McRae , Matthew Chantry , Peter D. Dueben , Tim N. Palmer

Synthesising photo-realistic images from natural language is one of the challenging problems in computer vision. Over the past decade, a number of approaches have been proposed, of which the improved Stacked Generative Adversarial Network…

Software Engineering · Computer Science 2021-10-05 Hyejin Park , Taaha Waseem , Wen Qi Teo , Ying Hwei Low , Mei Kuan Lim , Chun Yong Chong

Recent advancements in graph representation learning have shifted attention towards dynamic graphs, which exhibit evolving topologies and features over time. The increased use of such graphs creates a paramount need for generative models…

Machine Learning · Computer Science 2024-12-23 Ryien Hosseini , Filippo Simini , Venkatram Vishwanath , Henry Hoffmann

The use of synthetically generated data for training models is becoming a common practice. While generated data can augment the training data, repeated training on synthetic data raises concerns about distribution drift and degradation of…

Machine Learning · Computer Science 2025-12-16 Daniil Zverev , A. Sophia Koepke , Joao F. Henriques

Time series synthesis is an effective approach to ensuring the secure circulation of time series data. Existing time series synthesis methods typically perform temporal modeling based on random sequences to generate target sequences, which…

Machine Learning · Computer Science 2025-09-01 Xuan Hou , Shuhan Liu , Zhaohui Peng , Yaohui Chu , Yue Zhang , Yining Wang

Generative Adversarial Networks (GANs) have shown immense potential in fields such as text and image generation. Only very recently attempts to exploit GANs to statistical-mechanics models have been reported. Here we quantitatively test…

Statistical Mechanics · Physics 2024-05-07 Daniele Lanzoni , Olivier Pierre-Louis , Francesco Montalenti

In settings requiring synthetic data generation based on a clinical cohort, e.g., due to data protection regulations, heterogeneity across individuals might be a nuisance that we need to control or faithfully preserve. The sources of such…

Machine Learning · Computer Science 2023-12-14 Kiana Farhadyar , Federico Bonofiglio , Maren Hackenberg , Daniela Zoeller , Harald Binder

Simulator-based models are models for which the likelihood is intractable but simulation of synthetic data is possible. They are often used to describe complex real-world phenomena, and as such can often be misspecified in practice.…

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