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We develop novel numerical methods and perturbation approaches to determine the mean first passage time (MFPT) for a Brownian particle to be captured by either small stationary or mobile traps inside a bounded 2-D confining domain. Of…

Numerical Analysis · Mathematics 2019-11-20 Sarafa Iyaniwura , Tony Wong , Michael J. Ward , Colin B. Macdonald

Although the dynamics of colloids in the vicinity of a solid interface has been widely characterized in the past, experimental studies of Brownian diffusion close to an air-water interface are rare and limited to particle-interface gap…

Soft Condensed Matter · Physics 2022-11-11 Stefano Villa , Christophe Blanc , Abdallah Daddi-Moussa-Ider , Antonio Stocco , Maurizio Nobili

Encounter-based models of diffusion provide a probabilistic framework for analyzing the effects of a partially absorbing reactive surface, in which the probability of absorption depends upon the amount of surface-particle contact time.…

Statistical Mechanics · Physics 2023-07-05 Paul C Bressloff

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the…

We consider a particle undergoing diffusion with stochastic resetting in a bounded domain $\calU\subset \R^d$ for $d=2,3$. The domain is perforated by a set of partially absorbing targets within which the particle may be absorbed at a rate…

Statistical Mechanics · Physics 2021-10-14 Paul C. Bressloff , Ryan D. Schumm

The problem of a diffusing particle moving among diffusing traps is analyzed in general space dimension d. We consider the case where the traps are initially randomly distributed in space, with uniform density rho, and derive upper and…

Statistical Mechanics · Physics 2009-11-07 R. A. Blythe , A. J. Bray

Understanding the transport properties of a porous medium from a knowledge of its microstructure is a problem of great interest in the physical, chemical and biological sciences. Using a first-passage time method, we compute the mean…

Soft Condensed Matter · Physics 2009-07-03 J. Gevertz , S. Torquato

In this paper we develop an encounter-based model of reaction-subdiffusion in a domain $\Omega$ with a partially absorbing interior trap $\calU\subset \Omega$. We assume that the particle can freely enter and exit $\calU$, but is only…

Statistical Mechanics · Physics 2023-03-21 Paul C Bressloff

In this article, we study the narrow capture problem on a Riemannian 2-manifold. This involves the derivation of the mean first passage (sojourn) time of a surface-bound ion modelled as a Brownian particle. We use a layer potential argument…

Probability · Mathematics 2022-09-27 Medet Nursultanov , William Trad , Justin C. Tzou , Leo Tzou

A wide variety of physical, chemical, and biological processes involve diffusive particles interacting with surfaces containing reactive patches. The theory of boundary homogenization seeks to encapsulate the effective reactivity of such a…

Statistical Mechanics · Physics 2024-05-21 Claire E Plunkett , Sean D Lawley

In this paper we develop an encounter-based model of a run-and-tumble particle (RTP) confined to a finite interval $[0,L]$ with partially absorbing, sticky boundaries at both ends. We assume that the particle switches between two constant…

Statistical Mechanics · Physics 2023-05-10 Paul C. Bressloff

We calculate the exact asymptotic survival probability, Q, of a one-dimensional Brownian particle, initially located located at the point x in (-L,L), in the presence of two moving absorbing boundaries located at \pm(L+ct). The result is…

Statistical Mechanics · Physics 2015-06-25 Alan J. Bray , Richard Smith

Intracellular transport in living cells is often spatially inhomogeneous with an accelerated effective diffusion close to the cell membrane and a ballistic motion away from the centrosome due to active transport along actin filaments and…

Statistical Mechanics · Physics 2021-10-22 Matthieu Mangeat , Heiko Rieger

The mean first passage time (MFPT) for a Brownian particle to reach a small target in cellular microdomains is a key parameter for chemical activation. Although asymptotic estimations of the MFPT are available for various geometries, these…

Neurons and Cognition · Quantitative Biology 2015-03-19 Juergen Reingruber , David Holcman

In this paper we consider the diffusion of nanoparticles taken up by a semi-permeable spherical cell placed in the path of a diffusive particle field generated by an external planar source. The cell interior and exterior are characterized…

Biological Physics · Physics 2024-06-11 Stanley J. Miklavcic

We study a generalization of the standard trapping problem of random walk theory in which particles move subdiffusively on a one-dimensional lattice. We consider the cases in which the lattice is filled with a one-sided and a two-sided…

Statistical Mechanics · Physics 2007-05-23 S. B. Yuste , L. Acedo

Stochastically gated interfaces play an important role in a variety of cellular diffusion processes. Examples include intracellular transport via stochastically gated ion channels and pores in the plasma membrane of a cell, intercellular…

Statistical Mechanics · Physics 2026-01-21 Paul C Bressloff

We calculate the survival probability of an immobile target surrounded by a sea of uncorrelated diffusive or subdiffusive evanescent traps, i.e., traps that disappear in the course of their motion. Our calculation is based on a fractional…

Statistical Mechanics · Physics 2015-06-11 E. Abad , S. B. Yuste , Katja Lindenberg

The narrow escape problem deals with the calculation of the mean escape time (MET) of a Brownian particle from a bounded domain through a small hole on the domain's boundary. Here we develop a formalism that allows us to evaluate the…

Statistical Mechanics · Physics 2018-03-28 Tal Agranov , Baruch Meerson

We consider subdiffusion of a particle in a one-dimensional system with a thin partially permeable wall. Passing through the wall, the particle can be absorbed with a certain probability. We call such a wall partially permeable partially…

Statistical Mechanics · Physics 2021-02-17 Tadeusz Kosztołowicz