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Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow…

Applications · Statistics 2008-12-18 Bradley Efron

We consider sequential maximization of performance metrics that are general functions of a confusion matrix of a classifier (such as precision, F-measure, or G-mean). Such metrics are, in general, non-decomposable over individual instances,…

Machine Learning · Computer Science 2024-06-24 Wojciech Kotłowski , Marek Wydmuch , Erik Schultheis , Rohit Babbar , Krzysztof Dembczyński

In this paper we propose a computationally efficient multiple hypothesis testing procedure for persistent homology. The computational efficiency of our procedure is based on the observation that one can empirically simulate a null…

Computational Geometry · Computer Science 2022-08-29 Mikael Vejdemo-Johansson , Sayan Mukherjee

We consider the class of all multiple testing methods controlling tail probabilities of the false discovery proportion, either for one random set or simultaneously for many such sets. This class encompasses methods controlling familywise…

Statistics Theory · Mathematics 2022-05-02 Jelle Goeman , Jesse Hemerik , Aldo Solari

The problem of multiple hypothesis testing with observation control is considered in both fixed sample size and sequential settings. In the fixed sample size setting, for binary hypothesis testing, the optimal exponent for the maximal error…

Information Theory · Computer Science 2013-09-05 Sirin Nitinawarat , George Atia , Venugopal V. Veeravalli

The sequential multiple testing problem is considered under two generalized error metrics. Under the first one, the probability of at least $k$ mistakes, of any kind, is controlled. Under the second, the probabilities of at least $k_1$…

Statistics Theory · Mathematics 2019-02-18 Yanglei Song , Georgios Fellouris

Identifying the most powerful test in multiple hypothesis testing under strong family-wise error rate (FWER) control is a fundamental problem in statistical methodology. State-of-the-art approaches formulate this as a constrained…

Methodology · Statistics 2025-12-17 Prasanjit Dubey , Xiaoming Huo

Consider testing multiple hypotheses in the setting where the p-values of all hypotheses are unknown and thus have to be approximated using Monte Carlo simulations. One class of algorithms published in the literature for this scenario…

Statistics Theory · Mathematics 2020-06-16 Georg Hahn

The widespread adoption of online randomized controlled experiments (A/B Tests) for decision-making has created ongoing capacity constraints which necessitate interim analyses. As a consequence, platform users are increasingly motivated to…

Applications · Statistics 2025-11-11 Abbas Zaidi , Rina Friedberg , Samir Khan , Yao-Yang Leow , Maulik Soneji , Houssam Nassif , Richard Mudd

We propose a method for multiple hypothesis testing with familywise error rate (FWER) control, called the i-FWER test. Most testing methods are predefined algorithms that do not allow modifications after observing the data. However, in…

Methodology · Statistics 2021-04-20 Boyan Duan , Aaditya Ramdas , Larry Wasserman

We study sequential testing for a binary disease outcome when risk follows an unknown logistic model. At each round, the decision maker may either pay for a test revealing the true label or predict the outcome based on patient features and…

Machine Learning · Computer Science 2026-05-05 Tavor Z. Baharav , Spyros Dragazis , Aldo Pacchiano

Multiple hypotheses testing is a core problem in statistical inference and arises in almost every scientific field. Given a sequence of null hypotheses $\mathcal{H}(n) = (H_1,..., H_n)$, Benjamini and Hochberg…

Methodology · Statistics 2015-03-05 Adel Javanmard , Andrea Montanari

We introduce new online and batch algorithms that are robust to data with missing features, a situation that arises in many practical applications. In the online setup, we allow for the comparison hypothesis to change as a function of the…

Machine Learning · Computer Science 2012-02-19 Afshin Rostamizadeh , Alekh Agarwal , Peter Bartlett

Simultaneous inference allows for the exploration of data while deciding on criteria for proclaiming discoveries. It was recently proved that all admissible post-hoc inference methods for true discoveries must employ closed testing. In this…

Statistics Theory · Mathematics 2022-03-24 Jinjin Tian , Xu Chen , Eugene Katsevich , Jelle Goeman , Aaditya Ramdas

We are concerned with a situation in which we would like to test multiple hypotheses with tests whose p-values cannot be computed explicitly but can be approximated using Monte Carlo simulation. This scenario occurs widely in practice. We…

Methodology · Statistics 2018-10-17 Axel Gandy , Georg Hahn

We propose a unified framework to enhance the power of online multiple hypothesis testing procedures based on $e$-values. While $e$-value-based methods offer robust online False Discovery Rate (FDR) control under minimal assumptions, they…

Methodology · Statistics 2026-01-29 Qi Kuang , Bowen Gang , Yin Xia

Hypothesis tests under order restrictions arise in a wide range of scientific applications. By exploiting inequality constraints, such tests can achieve substantial gains in power and interpretability. However, these gains come at a cost:…

Methodology · Statistics 2026-02-18 Ori Davidov

The machine learning formulation of online learning is incomplete from a systems theoretic perspective. Typically, machine learning research emphasizes domains and tasks, and a problem solving worldview. It focuses on algorithm parameters,…

Machine Learning · Computer Science 2024-04-08 Anli du Preez , Peter A. Beling , Tyler Cody

Conformal prediction provides a principled framework for uncertainty quantification with finite-sample coverage guarantees. While recent work has extended conformal prediction to online and sequential settings, existing methods typically…

Machine Learning · Statistics 2026-05-14 Eduardo Ochoa Rivera , Ambuj Tewari

Even though offline evaluation is just an imperfect proxy of online performance -- due to the interactive nature of recommenders -- it will probably remain the primary way of evaluation in recommender systems research for the foreseeable…

Information Retrieval · Computer Science 2023-07-28 Balázs Hidasi , Ádám Tibor Czapp
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