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This dissertation presents the design, implementation and evaluation of GPU-accelerated simulation frameworks for Evolutionary Spatial Cyclic Games (ESCGs), a class of agent-based models used to study ecological and evolutionary dynamics.…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-08-26 Louie Sinadjan

The rapid growth of scientific software has created practical barriers for bioinformatics research. Although powerful statistical, artificial intelligence (AI)-based methods are now widely available, their effective use is often hindered by…

Software Engineering · Computer Science 2026-04-24 Simon Süwer , Zoe Chervontseva , Kester Bagemihl , Jan Baumbach , Olga Tsoy , Andreas Maier

Despite its widespread use in neural networks, error backpropagation has faced criticism for its lack of biological plausibility, suffering from issues such as the backward locking problem and the weight transport problem. These limitations…

Machine Learning · Computer Science 2024-10-24 Chia-Hsiang Kao , Bharath Hariharan

There is a large body of legacy scientific code written in languages like Fortran that is not optimised to get the best performance out of heterogeneous acceleration devices like GPUs and FPGAs, and manually porting such code into parallel…

Performance · Computer Science 2019-01-25 Wim Vanderbauwhede , Syed Waqar Nabi

Legacy codes are in ubiquitous use in scientific simulations; they are well-tested and there is significant time investment in their use. However, one challenge is the adoption of new, sometimes incompatible computing paradigms, such as GPU…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-11 Nicolas Nytko , Andrew Reisner , J. David Moulton , Luke N. Olson , Matthew West

Medical image processing is often limited by the computational cost of the involved algorithms. Whereas dedicated computing devices (GPUs in particular) exist and do provide significant efficiency boosts, they have an extra cost of use in…

Background: With the rapid growth of massively parallel sequencing technologies, still more laboratories are utilizing sequenced DNA fragments for genomic analyses. Interpretation of sequencing data is, however, strongly dependent on…

Convolutional Neural Networks (CNN) have been widely deployed in diverse application domains. There has been significant progress in accelerating both their training and inference using high-performance GPUs, FPGAs, and custom ASICs for…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-03-07 Guanwen Zhong , Akshat Dubey , Tan Cheng , Tulika Mitra

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

Machine Learning · Computer Science 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang

Achieving high performance for GPU codes requires developers to have significant knowledge in parallel programming and GPU architectures, and in-depth understanding of the application. This combination makes it challenging to find…

Software Engineering · Computer Science 2022-08-29 Jhe-Yu Liou , Muaaz Awan , Steven Hofmeyr , Stephanie Forrest , Carole-Jean Wu

Summary: Accurate phenotype prediction from genomic sequences is a highly coveted task in biological and medical research. While machine-learning holds the key to accurate prediction in a variety of fields, the complexity of biological data…

With the rapid development of information transmission, Software as a Service (SaaS) is developing at a rapid speed that everything originally local tends to be transplanted onto servers and executed on the cloud. WebGPU is such a SaaS…

Networking and Internet Architecture · Computer Science 2022-06-15 Hao Bai

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen

We present a port of the numerical relativity code SpEC which is capable of running on NVIDIA GPUs. Since this code must be maintained in parallel with SpEC itself, a primary design consideration is to perform as few explicit code changes…

General Relativity and Quantum Cosmology · Physics 2018-05-09 Adam G. M. Lewis , Harald P. Pfeiffer

Currently there is considerable interest in making use of many-core processor architectures, such as Nvidia and AMD graphics processing units (GPUs) for scientific computing. In this work we explore the use of the Open Computing Language…

General Relativity and Quantum Cosmology · Physics 2011-10-04 Niket K. Choudhary , Rakesh Ginjupalli , Sandeep Navada , Gaurav Khanna

The performance of discrete general purpose graphics processing units (GPGPUs) has been improving at a rapid pace. The PCIe interconnect that controls the communication of data between the system host memory and the GPU has not improved as…

Computational Physics · Physics 2019-05-15 Connor Kenyon , Glenn Volkema , Gaurav Khanna

Genetic Programming (GP) is a computationally intensive technique which also has a high degree of natural parallelism. Parallel computing architectures have become commonplace especially with regards Graphics Processing Units (GPU). Hence,…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-01-05 Darren M. Chitty

Motivation: The rapid growth of biological data has intensified the need for transparent, reproducible, and well-documented computational workflows. The ability to clearly connect the steps of a workflow in the code with their description…

Computation and Language · Computer Science 2026-03-10 Clémence Sebe , Olivier Ferret , Aurélie Névéol , Mahdi Esmailoghli , Ulf Leser , Sarah Cohen-Boulakia

We propose a language and compiler to productively build high-performance {\it software systolic arrays} that run on GPUs. Based on a rigorous mathematical foundation (uniform recurrence equations and space-time transform), our language has…

Programming Languages · Computer Science 2020-11-02 Hongbo Rong , Xiaochen Hao , Yun Liang , Lidong Xu , Hong H Jiang , Pradeep Dubey

This paper studies Semi-Supervised Domain Adaptation (SSDA), a practical yet under-investigated research topic that aims to learn a model of good performance using unlabeled samples and a few labeled samples in the target domain, with the…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Kai Li , Chang Liu , Handong Zhao , Yulun Zhang , Yun Fu