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Gene Regulatory Networks (GRNs) are intricate biological systems that control gene expression and regulation in response to environmental and developmental cues. Advances in computational biology, coupled with high throughput sequencing…

Machine Learning · Computer Science 2025-04-18 Akshata Hegde , Tom Nguyen , Jianlin Cheng

Gaussian graphical models represent the underlying graph structure of conditional dependence between random variables which can be determined using their partial correlation or precision matrix. In a high-dimensional setting, the precision…

Applications · Statistics 2016-05-24 Adria Caballe , Natalia Bochkina , Claus Mayer

Message-passing Graph Neural Networks (GNNs), which collect information from adjacent nodes achieve dismal performance on heterophilic graphs. Various schemes have been proposed to solve this problem, and propagating signed information on…

Machine Learning · Computer Science 2024-10-01 Yoonhyuk Choi , Jiho Choi , Taewook Ko , Chong-Kwon Kim

As machine learning becomes more widely adopted across domains, it is critical that researchers and ML engineers think about the inherent biases in the data that may be perpetuated by the model. Recently, many studies have shown that such…

Machine Learning · Computer Science 2022-10-21 Sean Current , Yuntian He , Saket Gurukar , Srinivasan Parthasarathy

Like Graph Neural Networks (GNNs), Signed Graph Neural Networks (SGNNs) are also up against fairness issues from source data and typical aggregation method. In this paper, we are pioneering to make the investigation of fairness in SGNNs…

Machine Learning · Computer Science 2024-08-19 Fang He , Jinhai Deng , Ruizhan Xue , Maojun Wang , Zeyu Zhang

Data-driven analysis of complex networks has been in the focus of research for decades. An important area of research is to study how well real networks can be described with a small selection of metrics, furthermore how well network models…

Social and Information Networks · Computer Science 2022-04-28 Marcell Nagy , Roland Molontay

Graph neural networks (GNNs) face significant challenges with class imbalance, leading to biased inference results. To address this issue in heterogeneous graphs, we propose a novel framework that combines Graph Neural Network (GNN) and…

Machine Learning · Computer Science 2024-11-26 Hung-Chun Hsu , Bo-Jun Wu , Ming-Yi Hong , Che Lin , Chih-Yu Wang

Graph Neural Networks (GNNs) achieve an impressive performance on structured graphs by recursively updating the representation vector of each node based on its neighbors, during which parameterized transformation matrices should be learned…

Machine Learning · Computer Science 2019-06-14 Pengfei Chen , Weiwen Liu , Chang-Yu Hsieh , Guangyong Chen , Shengyu Zhang

The study of social networks is a burgeoning research area. However, most existing work deals with networks that simply encode whether relationships exist or not. In contrast, relationships in signed networks can be positive ("like",…

Social and Information Networks · Computer Science 2013-03-06 Kai-Yang Chiang , Cho-Jui Hsieh , Nagarajan Natarajan , Ambuj Tewari , Inderjit S. Dhillon

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

Molecular Networks · Quantitative Biology 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

Random graph models are frequently used as a controllable and versatile data source for experimental campaigns in various research fields. Generating such data-sets at scale is a non-trivial task as it requires design decisions typically…

Data Structures and Algorithms · Computer Science 2020-03-03 Manuel Penschuck , Ulrik Brandes , Michael Hamann , Sebastian Lamm , Ulrich Meyer , Ilya Safro , Peter Sanders , Christian Schulz

The loss surface of deep neural networks has recently attracted interest in the optimization and machine learning communities as a prime example of high-dimensional non-convex problem. Some insights were recently gained using spin glass…

Machine Learning · Statistics 2017-06-05 C. Daniel Freeman , Joan Bruna

The choice of free parameters in network models is subjective, since it depends on what topological properties are being monitored. However, we show that the Maximum Likelihood (ML) principle indicates a unique, statistically rigorous…

Disordered Systems and Neural Networks · Physics 2008-08-07 Diego Garlaschelli , Maria I. Loffredo

Gene Regulatory Network (GRN) plays an important role in knowing insight of cellular life cycle. It gives information about at which different environmental conditions genes of particular interest get over expressed or under expressed.…

Computational Engineering, Finance, and Science · Computer Science 2013-10-10 Chanda Panse , Dr. Manali Kshirsagar

Graph Neural Networks (GNNs) have emerged as a notorious alternative to address learning problems dealing with non-Euclidean datasets. However, although most works assume that the graph is perfectly known, the observed topology is prone to…

Machine Learning · Computer Science 2023-12-12 Victor M. Tenorio , Samuel Rey , Antonio G. Marques

In practice, since many communication networks are huge in scale, or complicated in structure, or even dynamic, the predesigned linear network codes based on the network topology is impossible even if the topological structure is known.…

Information Theory · Computer Science 2013-02-26 Xuan Guang , Fang-Wei Fu

Empirical studies of graphs have contributed enormously to our understanding of complex systems. Known today as network science, what was originally a theoretical study of graphs has grown into a more scientific exploration of communities…

Quantitative Methods · Quantitative Biology 2020-01-01 Ryan E. Langendorf , Debra S. Goldberg

Desirable random graph models (RGMs) should (i) reproduce common patterns in real-world graphs (e.g., power-law degrees, small diameters, and high clustering), (ii) generate variable (i.e., not overly similar) graphs, and (iii) remain…

Machine Learning · Computer Science 2025-09-26 Fanchen Bu , Ruochen Yang , Paul Bogdan , Kijung Shin

Graphs are naturally used to describe the structures of various real-world systems in biology, society, computer science etc., where subgraphs or motifs as basic blocks play an important role in function expression and information…

Social and Information Networks · Computer Science 2021-02-11 Jinhuan Wang , Pengtao Chen , Bin Ma , Jiajun Zhou , Zhongyuan Ruan , Guanrong Chen , Qi Xuan

Genes communicate with each other through different regulatory effects, which lead to the emergence of complex structures in cells, and such structures are expected to be different for normal and cancerous cells. To study breast cancer…

Molecular Networks · Quantitative Biology 2020-10-13 Abbas Karimi Rizi , Mina Zamani , Amirhossein Shirazi , G. Reza Jafari , János Kertész