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Ensuring that machine learning (ML) models are safe, effective, and equitable across all patients is critical for clinical decision-making and for preventing the amplification of existing health disparities. In this work, we examine how…

Machine Learning · Computer Science 2025-05-28 Jianhui Gao , Benson Chou , Zachary R. McCaw , Hilary Thurston , Paul Varghese , Chuan Hong , Jessica Gronsbell

Large Language Models (LLMs) have emerged as promising solutions for a variety of medical and clinical decision support applications. However, LLMs are often subject to different types of biases, which can lead to unfair treatment of…

Computation and Language · Computer Science 2024-08-23 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

Recent advancements in large language models have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question answering for…

Computation and Language · Computer Science 2024-10-15 Yuelyu Ji , Wenhe Ma , Sonish Sivarajkumar , Hang Zhang , Eugene Mathew Sadhu , Zhuochun Li , Xizhi Wu , Shyam Visweswaran , Yanshan Wang

Machine learning methods applied to complex biomedical data has enabled the construction of disease signatures of diagnostic/prognostic value. However, less attention has been given to understanding disease heterogeneity. Semi-supervised…

Quantitative Methods · Quantitative Biology 2020-06-30 Zhijian Yang , Junhao Wen , Christos Davatzikos

For companies developing products or algorithms, it is important to understand the potential effects not only globally, but also on sub-populations of users. In particular, it is important to detect if there are certain groups of users that…

Machine Learning · Computer Science 2020-10-28 Amir Sepehri , Cyrus DiCiccio

Multimodal large language models (MLLMs) have shown strong potential for medical image reasoning, yet fairness across demographic groups remains a major concern. Existing debiasing methods often rely on large labeled datasets or…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Dawei Li , Zijian Gu , Peng Wang , Chuhan Song , Zhen Tan , Mohan Zhang , Tianlong Chen , Yu Tian , Song Wang

Medical artificial intelligence systems have achieved remarkable diagnostic capabilities, yet they consistently exhibit performance disparities across demographic groups, causing real-world harm to underrepresented populations. While recent…

Machine Learning · Computer Science 2025-10-24 Shiqi Dai , Wei Dai , Jiaee Cheong , Paul Pu Liang

Automated pain detection through machine learning (ML) and deep learning (DL) algorithms holds significant potential in healthcare, particularly for patients unable to self-report pain levels. However, the accuracy and fairness of these…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Dylan Green , Yuting Shang , Jiaee Cheong , Yang Liu , Hatice Gunes

Fairness constitutes a concern within machine learning (ML) applications. Currently, there is no study on how disparities in classification complexity between privileged and unprivileged groups could influence the fairness of solutions,…

Machine Learning · Computer Science 2025-04-09 Juliett Suárez Ferreira , Marija Slavkovik , Jorge Casillas

Many internet applications are powered by machine learned models, which are usually trained on labeled datasets obtained through either implicit / explicit user feedback signals or human judgments. Since societal biases may be present in…

Machine Learning · Computer Science 2020-08-18 Sriram Vasudevan , Krishnaram Kenthapadi

Machine learning (ML) is increasingly being used in image retrieval systems for medical decision making. One application of ML is to retrieve visually similar medical images from past patients (e.g. tissue from biopsies) to reference when…

There is growing interest in AI systems that support human decision-making in high-stakes domains (e.g., medical diagnosis) to improve decision quality and reduce cognitive load. Mainstream approaches pair human experts with a…

Artificial Intelligence · Computer Science 2026-03-26 Debodeep Banerjee , Stefano Teso , Burcu Sayin , Andrea Passerini

This paper investigates algorithmic bias in language-based models for automated depression detection, focusing on socio-demographic disparities related to gender and race/ethnicity. Models trained using deep neural networks (DNN) based…

Computation and Language · Computer Science 2026-01-28 Obed Junias , Prajakta Kini , Theodora Chaspari

Bias evaluation in machine-learning based services (MLS) based on traditional algorithmic fairness notions that rely on comparative principles is practically difficult, making it necessary to rely on human auditor feedback. However, in…

Machine Learning · Computer Science 2021-07-06 Mukund Telukunta , Venkata Sriram Siddhardh Nadendla

Existing approaches to bias evaluation in large language models (LLMs) trade ecological validity for statistical control, relying either on artificial prompts that poorly reflect real-world use or on naturalistic tasks that lack scale and…

Computation and Language · Computer Science 2026-05-12 Akram Elbouanani , Aboubacar Tuo , Adrian Popescu

The increasing global prevalence of mental disorders, such as depression and PTSD, requires objective and scalable diagnostic tools. Traditional clinical assessments often face limitations in accessibility, objectivity, and consistency.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-03 Abdelrahaman A. Hassan , Abdelrahman A. Ali , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda

As machine learning methods gain prominence within clinical decision-making, addressing fairness concerns becomes increasingly urgent. Despite considerable work dedicated to detecting and ameliorating algorithmic bias, today's methods are…

Machine Learning · Computer Science 2023-08-01 Charles Jones , Daniel C. Castro , Fabio De Sousa Ribeiro , Ozan Oktay , Melissa McCradden , Ben Glocker

Business logic vulnerabilities have become one of the most damaging yet least understood classes of smart contract vulnerabilities. Unlike traditional bugs such as reentrancy or arithmetic errors, these vulnerabilities arise from missing or…

Cryptography and Security · Computer Science 2026-02-04 Jiaqi Gao , Zijian Zhang , Yuqiang Sun , Ye Liu , Chengwei Liu , Han Liu , Yi Li , Yang Liu

Machine learning (ML) models are increasingly used to support clinical decision-making. However, real-world medical datasets are often noisy, incomplete, and imbalanced, leading to performance disparities across patient subgroups. These…

Deep learning in medical imaging faces obstacles: limited data diversity, ethical issues, high acquisition costs, and the need for precise annotations. Bleeding detection and localization during surgery is especially challenging due to the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-18 Niran Nataraj , Maina Sogabe , Kenji Kawashima