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In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well…

Quantitative Methods · Quantitative Biology 2020-03-11 Razvan V. Marinescu

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

Machine Learning · Computer Science 2021-01-13 Alexander Lavin

Self-supervised pretraining followed by supervised fine-tuning has seen success in image recognition, especially when labeled examples are scarce, but has received limited attention in medical image analysis. This paper studies the…

Stacking excessive layers in DNN results in highly underdetermined system when training samples are limited, which is very common in medical applications. In this regard, we present a framework capable of deriving an efficient…

Machine Learning · Computer Science 2025-03-04 Seunghun Baek , Injun Choi , Mustafa Dere , Minjeong Kim , Guorong Wu , Won Hwa Kim

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

Quantitative Methods · Quantitative Biology 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas

Deep learning (DL) for predicting Alzheimer's disease (AD) has provided timely intervention in disease progression yet still demands attentive interpretability to explain how their DL models make definitive decisions. Recently,…

Artificial Intelligence · Computer Science 2023-10-06 Kwanseok Oh , Da-Woon Heo , Ahmad Wisnu Mulyadi , Wonsik Jung , Eunsong Kang , Kun Ho Lee , Heung-Il Suk

Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder with substantial heterogeneity in progression and treatment response. Despite recent therapeutic advances, predictive models capable of accurately forecasting…

Machine Learning · Computer Science 2025-07-23 Jindong Wang , Yutong Mao , Xiao Liu , Wenrui Hao

The rise of Alzheimers Disease worldwide has prompted a search for efficient tools which can be used to predict deterioration in cognitive decline leading to dementia. In this paper, we explore the potential of survival machine learning as…

Machine Learning · Computer Science 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

This work presents a novel label-efficient selfsupervised representation learning-based approach for classifying diabetic retinopathy (DR) images in cross-domain settings. Most of the existing DR image classification methods are based on…

Image and Video Processing · Electrical Eng. & Systems 2023-04-25 Ekta Gupta , Varun Gupta , Muskaan Chopra , Prakash Chandra Chhipa , Marcus Liwicki

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

Machine Learning · Computer Science 2019-03-25 Jack Albright

Deep learning has been recently used for the analysis of neuroimages, such as structural magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), and has achieved significant performance improvements over…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Li Zhang , Mingliang Wang , Mingxia Liu , Daoqiang Zhang

Semi-supervised learning has made significant strides in the medical domain since it alleviates the heavy burden of collecting abundant pixel-wise annotated data for semantic segmentation tasks. Existing semi-supervised approaches enhance…

Computer Vision and Pattern Recognition · Computer Science 2021-12-03 Xu Zheng , Chong Fu , Haoyu Xie , Jialei Chen , Xingwei Wang , Chiu-Wing Sham

Sensory input from multiple sources is crucial for robust and coherent human perception. Different sources contribute complementary explanatory factors. Similarly, research studies often collect multimodal imaging data, each of which can…

The imaging community has increasingly adopted machine learning (ML) methods to provide individualized imaging signatures related to disease diagnosis, prognosis, and response to treatment. Clinical neuroscience and cancer imaging have been…

Effective and accurate diagnosis of Alzheimer's disease (AD) or mild cognitive impairment (MCI) can be critical for early treatment and thus has attracted more and more attention nowadays. Since first introduced, machine learning methods…

Computer Vision and Pattern Recognition · Computer Science 2014-04-29 Fayao Liu , Chunhua Shen

Brain age prediction using neuroimaging data has shown great potential as an indicator of overall brain health and successful aging, as well as a disease biomarker. Deep learning models have been established as reliable and efficient brain…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Bruno Machado Pacheco , Victor Hugo Rocha de Oliveira , Augusto Braga Fernandes Antunes , Saulo Domingos de Souza Pedro , Danilo Silva

Early diagnosis of Alzheimer's disease (AD) is essential in preventing the disease's progression. Therefore, detecting AD from neuroimaging data such as structural magnetic resonance imaging (sMRI) has been a topic of intense investigation…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Maha M. Alwuthaynani , Zahraa S. Abdallah , Raul Santos-Rodriguez

Alzheimer's disease is an untreatable, progressive brain disorder that slowly robs people of their memory, thinking abilities, and ultimately their capacity to complete even the most basic tasks. Among older adults, it is the most frequent…

Image and Video Processing · Electrical Eng. & Systems 2025-02-11 Nasser A Alsadhan

Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD). In clinical trials, estimation of brain progressive rates can be…

Neurons and Cognition · Quantitative Biology 2023-04-11 Mengjin Dong , Long Xie , Sandhitsu R. Das , Jiancong Wang , Laura E. M. Wisse , Robin deFlores , David A. Wolk , Paul A. Yushkevich