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Alignment-based sequence similarity searches, while accurate for some type of sequences, can produce incorrect results when used on more divergent but functionally related sequences that have undergone the sequence rearrangements observed…

Genomics · Quantitative Biology 2015-01-21 Ivan Borozan , Stuart Watt , Vincent Ferretti

The advent of highly accurate protein structure prediction methods has fueled an exponential expansion of the protein structure database. Consequently, there is a rising demand for rapid and precise structural homolog search. Traditional…

Biomolecules · Quantitative Biology 2023-12-01 Yuan Liu , Hong-Bin Shen

We argue that time series analysis is fundamentally different in nature to either vision or natural language processing with respect to the forms of meaningful self-supervised learning tasks that can be defined. Motivated by this insight,…

Machine Learning · Computer Science 2023-12-13 Navid Mohammadi Foumani , Chang Wei Tan , Geoffrey I. Webb , Hamid Rezatofighi , Mahsa Salehi

Audio Word2Vec offers vector representations of fixed dimensionality for variable-length audio segments using Sequence-to-sequence Autoencoder (SA). These vector representations are shown to describe the sequential phonetic structures of…

Computation and Language · Computer Science 2018-02-20 Chia-Hao Shen , Janet Y. Sung , Hung-Yi Lee

This study explores the use of deep learning techniques for analyzing lung Computed Tomography (CT) images. Classic deep learning approaches face challenges with varying slice counts and resolutions in CT images, a diversity arising from…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Chih-Chung Hsu , Chia-Ming Lee , Yang Fan Chiang , Yi-Shiuan Chou , Chih-Yu Jiang , Shen-Chieh Tai , Chi-Han Tsai

DNA cloning methods are fundamental tools in molecular biology, synthetic biology, and genetic engineering that enable precise DNA manipulation for various scientific and biotechnological applications. This review systematically summarizes…

Biomolecules · Quantitative Biology 2025-05-07 Isabella Frighetto Bomfiglio , Isabelli Seiler de Medeiros Mendes , Diego Bonatto

This study aims to develop a single integrated spoofing-aware speaker verification (SASV) embeddings that satisfy two aspects. First, rejecting non-target speakers' input as well as target speakers' spoofed inputs should be addressed.…

Visualizing high-dimensional datasets through a generalized embedding has been a challenge for a long time. Several methods have shown up for the same, but still, they have not been able to generate a generalized embedding, which not only…

Machine Learning · Computer Science 2024-10-21 Chayan Maitra , Rajat K. De

In contrast to regular (simple) networks, hyper networks possess the ability to depict more complex relationships among nodes and store extensive information. Such networks are commonly found in real-world applications, such as in social…

Social and Information Networks · Computer Science 2023-11-08 Shu Liu , Cameron Lai , Fujio Toriumi

In this paper, we present subgraph2vec, a novel approach for learning latent representations of rooted subgraphs from large graphs inspired by recent advancements in Deep Learning and Graph Kernels. These latent representations encode…

Machine Learning · Computer Science 2016-06-30 Annamalai Narayanan , Mahinthan Chandramohan , Lihui Chen , Yang Liu , Santhoshkumar Saminathan

Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is…

Quantitative Methods · Quantitative Biology 2015-05-27 Kévin Vervier , Pierre Mahé , Maud Tournoud , Jean-Baptiste Veyrieras , Jean-Philippe Vert

Recent advances in healthcare technologies have led to the availability of large amounts of biological samples across several techniques and applications. In particular, in the last few years, Raman spectroscopy analysis of biological…

Quantitative Methods · Quantitative Biology 2025-06-24 Marco Piazza , Andrea Spinelli , Francesca Maggioni , Marzia Bedoni , Enza Messina

Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly hard in an…

Methodology · Statistics 2022-03-22 Emilie Eliseussen , Thomas Fleischer , Valeria Vitelli

Messenger RNA (mRNA)-based vaccines are accelerating the discovery of new drugs and revolutionizing the pharmaceutical industry. However, selecting particular mRNA sequences for vaccines and therapeutics from extensive mRNA libraries is…

Quantitative Methods · Quantitative Biology 2024-12-23 Honggen Zhang , Xiangrui Gao , June Zhang , Lipeng Lai

Training-free embedding methods directly leverage pretrained large language models (LLMs) to embed text, bypassing the costly and complex procedure of contrastive learning. Previous training-free embedding methods have mainly focused on…

Computation and Language · Computer Science 2025-02-11 Raghuveer Thirukovalluru , Bhuwan Dhingra

Image retrieval is crucial in robotics and computer vision, with downstream applications in robot place recognition and vision-based product recommendations. Modern retrieval systems face two key challenges: scalability and efficiency.…

Information Retrieval · Computer Science 2025-04-03 Mohammad Omama , Po-han Li , Sandeep P. Chinchali

Kernel classifiers and regressors designed for structured data, such as sequences, trees and graphs, have significantly advanced a number of interdisciplinary areas such as computational biology and drug design. Typically, kernels are…

Machine Learning · Computer Science 2020-01-14 Hanjun Dai , Bo Dai , Le Song

Graph-based methods are known to be successful in many machine learning and pattern classification tasks. These methods consider semi-structured data as graphs where nodes correspond to primitives (parts, interest points, segments, etc.)…

Computer Vision and Pattern Recognition · Computer Science 2018-03-02 Anjan Dutta , Hichem Sahbi

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

Sequence modelling approaches for epigenetic profile prediction have recently expanded in terms of sequence length, model size, and profile diversity. However, current models cannot infer on many experimentally feasible tissue and assay…

Genomics · Quantitative Biology 2023-08-24 Jacob Deasy , Ron Schwessinger , Ferran Gonzalez , Stephen Young , Kim Branson
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