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A new modification of the Neural Additive Model (NAM) called SurvNAM and its modifications are proposed to explain predictions of the black-box machine learning survival model. The method is based on applying the original NAM to solving the…

Machine Learning · Computer Science 2021-04-20 Lev V. Utkin , Egor D. Satyukov , Andrei V. Konstantinov

Survival analysis is a fundamental tool for modeling time-to-event outcomes in healthcare. Recent advances have introduced flexible neural network approaches for improved predictive performance. However, most of these models do not provide…

Machine Learning · Statistics 2025-09-10 Mert Ketenci , Vincent Jeanselme , Harry Reyes Nieva , Shalmali Joshi , Noémie Elhadad

Competing risks are crucial considerations in survival modelling, particularly in healthcare domains where patients may experience multiple distinct event types. We propose CRISP-NAM (Competing Risks Interpretable Survival Prediction with…

Machine Learning · Computer Science 2025-09-26 Dhanesh Ramachandram , Ananya Raval

The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing…

Machine Learning · Computer Science 2025-12-02 Abdallah Alabdallah , Omar Hamed , Mattias Ohlsson , Thorsteinn Rögnvaldsson , Sepideh Pashami

In this study, we present a hybrid CNN-RNN approach to investigate long-term survival of subjects in a lung cancer screening study. Subjects who died of cardiovascular and respiratory causes were identified whereby the CNN model was used to…

Machine Learning · Computer Science 2023-03-21 Yaozhi Lu , Shahab Aslani , An Zhao , Ahmed Shahin , David Barber , Mark Emberton , Daniel C. Alexander , Joseph Jacob

Survival analysis, or time-to-event analysis, is an important and widespread problem in healthcare research. Medical research has traditionally relied on Cox models for survival analysis, due to their simplicity and interpretability. Cox…

Machine Learning · Computer Science 2023-10-25 Mike Van Ness , Tomas Bosschieter , Natasha Din , Andrew Ambrosy , Alexander Sandhu , Madeleine Udell

Relative survival represents the preferred framework for the analysis of population cancer survival data. The aim is to model the survival probability associated to cancer in the absence of information about the cause of death. Recent data…

Recent radiomic studies have witnessed promising performance of deep learning techniques in learning radiomic features and fusing multimodal imaging data. Most existing deep learning based radiomic studies build predictive models in a…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Pamela Boimel , James Janopaul-Naylor , Haoyu Zhong , Ying Xiao , Edgar Ben-Josef , Yong Fan

Demand forecasts are the crucial basis for numerous business decisions, ranging from inventory management to strategic facility planning. While machine learning (ML) approaches offer accuracy gains, their interpretability and acceptance are…

Machine Learning · Computer Science 2024-04-08 Leif Feddersen , Catherine Cleophas

Accurate survival prediction in head and neck cancer (HNC) is essential for guiding clinical decision-making and optimizing treatment strategies. Traditional models, such as Cox proportional hazards, have been widely used but are limited in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Aiman Farooq , Utkarsh Sharma , Deepak Mishra

In cancer epidemiology, the \emph{relative survival framework} is used to quantify the hazard associated with cancer by comparing the all-cause mortality hazard in cancer patients to that of the general population. This framework assumes…

Applications · Statistics 2024-11-05 Piyali Basak , Antonio R. Linero , Camille Maringe , F. Javier Rubio

Excess hazard modeling is one of the main tools in population-based cancer survival research. Indeed, this setting allows for direct modeling of the survival due to cancer even in the absence of reliable information on the cause of death,…

Methodology · Statistics 2022-04-12 A. Eletti , G. Marra , M. Quaresma , R. Radice , F. J. Rubio

Deep neural networks (DNNs) are powerful black-box predictors that have achieved impressive performance on a wide variety of tasks. However, their accuracy comes at the cost of intelligibility: it is usually unclear how they make their…

Machine Learning · Computer Science 2021-10-26 Rishabh Agarwal , Levi Melnick , Nicholas Frosst , Xuezhou Zhang , Ben Lengerich , Rich Caruana , Geoffrey Hinton

Prognostic models in survival analysis are aimed at understanding the relationship between patients' covariates and the distribution of survival time. Traditionally, semi-parametric models, such as the Cox model, have been assumed. These…

Machine Learning · Statistics 2020-11-06 Denise Rava , Jelena Bradic

Survival prediction is an important branch of cancer prognosis analysis. The model that predicts survival risk through TCGA genomics data can discover genes related to cancer and provide diagnosis and treatment recommendations based on…

Machine Learning · Computer Science 2024-05-14 Wankang Zhai

The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In…

Machine Learning · Computer Science 2017-01-27 Zhengping Che , Yu Cheng , Zhaonan Sun , Yan Liu

Cox proportional hazard model (CPH) is commonly used in clinical research for survival analysis. In quantitative medical imaging (radiomics) studies, CPH plays an important role in feature reduction and modeling. However, the underlying…

Quantitative Methods · Quantitative Biology 2019-06-27 Yucheng Zhang , Edrise M. Lobo-Mueller , Paul Karanicolas , Steven Gallinger , Masoom A. Haider , Farzad Khalvati

In this paper we utilize a survival analysis methodology incorporating Bayesian additive regression trees to account for nonlinear and additive covariate effects. We compare the performance of Bayesian additive regression trees, Cox…

Applications · Statistics 2019-11-05 Satabdi Saha , Duchwan Ryu , Nader Ebrahimi

Deep neural networks have revolutionized many fields, but their black-box nature also occasionally prevents their wider adoption in fields such as healthcare and finance, where interpretable and explainable models are required. The recent…

Machine Learning · Computer Science 2024-03-20 Wei Zhang , Brian Barr , John Paisley

Neural additive models (NAMs) enhance the transparency of deep neural networks by handling input features in separate additive sub-networks. However, they lack inherent mechanisms that provide calibrated uncertainties and enable selection…

Machine Learning · Statistics 2024-10-29 Kouroche Bouchiat , Alexander Immer , Hugo Yèche , Gunnar Rätsch , Vincent Fortuin
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