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Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, changes in the distribution of glucose measurements can reveal patterns of disease progression…

Machine Learning · Statistics 2026-03-26 Antonio Álvarez-López , Marcos Matabuena

Rapid changes in blood glucose levels can have severe and immediate health consequences, leading to the need to develop indices for assessing these rapid changes based on continuous glucose monitoring (CGM) data. We proposed a CGM index,…

Quantitative Methods · Quantitative Biology 2025-06-17 Dandan Wang , Xiaoyan Chen , Jingxiang Lin , Teng Zhang , Lianyi Huang , Dongliang Leng , Xiaohua Douglas Zhang , Gang Li

Continuous Blood Glucose (CGM) monitors have revolutionized the ability of diabetics to manage their blood glucose, and paved the way for artificial pancreas systems. In this paper we augment CGM data with sensor input collected by a smart…

Human-Computer Interaction · Computer Science 2023-02-06 Sam Royston

Describing dynamic medical systems using machine learning is a challenging topic with a wide range of applications. In this work, the possibility of modeling the blood glucose level of diabetic patients purely on the basis of measured data…

Machine Learning · Computer Science 2023-03-10 David Jödicke , Daniel Parra , Gabriel Kronberger , Stephan Winkler

The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either…

Tissues and Organs · Quantitative Biology 2019-06-19 Afroza Shirin , Fabio Della Rossa , Isaac Klickstein , John Russell , Francesco Sorrentino

Individualized therapy is driven forward by medical data analysis, which provides insight into the patient's context. In particular, for Type 1 Diabetes (T1D), which is an autoimmune disease, relationships between demographics, sensor data,…

Signal Processing · Electrical Eng. & Systems 2026-04-23 Beyza Cinar , Maria Maleshkova

People with diabetes need insulin delivery to effectively manage their blood glucose levels, especially after meals, because their bodies either do not produce enough insulin or cannot fully utilize it. Accurate insulin delivery starts with…

Systems and Control · Electrical Eng. & Systems 2024-11-21 Hanyu Zeng , Hui Ji , Pengfei Zhou

Type 1 diabetes (T1D) is an autoimmune disease of the beta cells of the pancreas. The nonobese diabetic (NOD) mouse is a commonly used animal model, with roughly an 80% incidence rate of T1D among females. In 100% of NOD mice, macrophages…

Tissues and Organs · Quantitative Biology 2014-12-23 James R. Moore , Fred Adler

Background and objective: Hybrid automated insulin delivery (hAID) systems represent the most advanced therapy for type 1 diabetes (T1D). Current systems rely on linear or linearized models of glucose homeostasis, which may compromise…

Systems and Control · Electrical Eng. & Systems 2025-12-08 Vihangkumar V. Naik , Eleonora Manzoni , Clara Escorihuela-Altaba , Jose Garcia-Tirado

Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In…

Machine Learning · Computer Science 2018-12-04 Matthew O'Kelly , Aman Sinha , Justin Norden , Hongseok Namkoong

Given the growing prevalence of diabetes, there has been significant interest in determining how diabetes affects instrumental daily functions, like driving. Complication of glucose control in diabetes includes hypoglycemic and…

Personal health devices can enable continuous monitoring of health parameters. However, the benefit of these devices is often directly related to the frequency of use. Therefore, adherence to personal health devices is critical. This paper…

Computers and Society · Computer Science 2020-06-11 Sudip Vhaduri , Temiloluwa Prioleau

Precise and timely forecasting of blood glucose levels is essential for effective diabetes management. While extensive research has been conducted on Type 1 diabetes mellitus, Type 2 diabetes mellitus (T2DM) presents unique challenges due…

Computational Engineering, Finance, and Science · Computer Science 2024-09-12 Yuyang Sun , Panagiotis Kosmas

In the UK, approximately 400,000 people with type 1 diabetes (T1D) rely on insulin delivery due to insufficient pancreatic insulin production. Managing blood glucose (BG) levels is crucial, with continuous glucose monitoring (CGM) playing a…

Machine Learning · Computer Science 2023-12-21 Chengzhe Piao , Ken Li

The rapid growth in mobile healthcare technology could significantly help control chronic diseases, such as diabetes. This paper presents a systematic review to characterise type 1 & type 2 diabetes management applications available in…

Computers and Society · Computer Science 2019-04-23 Ahmed Fadhil , Yunlong Wang

The management of type 1 diabetes has been revolutionized by the artificial pancreas system (APS), which automates insulin delivery based on continuous glucose monitor (CGM). While conventional closed-loop systems rely on CGM data, which…

Systems and Control · Electrical Eng. & Systems 2024-11-19 Debayani Ghosh , Sahaj Saxena , Navin Kumar

Background: This study investigates glucose conditions preceding and following various hypoglycemia levels in individuals with type 1 diabetes using open-source automated insulin delivery (AID) systems. It also seeks to evaluate…

Quantitative Methods · Quantitative Biology 2024-05-16 Arsalan Shahid , Dana M. Lewis

Type 1 diabetes (T1D) management can be significantly enhanced through the use of predictive machine learning (ML) algorithms, which can mitigate the risk of adverse events like hypoglycemia. Hypoglycemia, characterized by blood glucose…

Quantitative Methods · Quantitative Biology 2025-04-02 Beyza Cinar , Jennifer Daniel Onwuchekwa , Maria Maleshkova

In this paper we investigate the use of model-based reinforcement learning to assist people with Type 1 Diabetes with insulin dose decisions. The proposed architecture consists of multiple Echo State Networks to predict blood glucose levels…

Despite the well-acknowledged benefits of physical activity for type 2 diabetes (T2D) prevention, the literature surprisingly lacks validated models able to predict the long-term benefits of exercise on T2D progression and support…

Systems and Control · Electrical Eng. & Systems 2024-04-24 Pierluigi Francesco De Paola , Alessandro Borri , Fabrizio Dabbene , Karim Keshavjee , Pasquale Palumbo , Alessia Paglialonga