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Statistical inference of genetic regulatory networks is essential for understanding temporal interactions of regulatory elements inside the cells. For inferences of large networks, identification of network structure is typical achieved…

Quantitative Methods · Quantitative Biology 2008-04-07 Heng Lian

Mixed membership factorization is a popular approach for analyzing data sets that have within-sample heterogeneity. In recent years, several algorithms have been developed for mixed membership matrix factorization, but they only guarantee…

Methodology · Statistics 2016-10-26 Fan Zhang , Chuangqi Wang , Andrew Trapp , Patrick Flaherty

We present a novel classification-based method for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a decision rule for…

Quantitative Methods · Quantitative Biology 2007-05-23 Manuel Middendorf , Anshul Kundaje , Chris Wiggins , Yoav Freund , Christina Leslie

We propose a novel sparse sliced inverse regression method based on random projections in a large $p$ small $n$ setting. Embedded in a generalized eigenvalue framework, the proposed approach finally reduces to parallel execution of…

Methodology · Statistics 2023-08-04 Jia Zhang , Runxiong Wu , Xin Chen

This paper proposes a new algorithm for multiple sparse regression in high dimensions, where the task is to estimate the support and values of several (typically related) sparse vectors from a few noisy linear measurements. Our algorithm is…

Machine Learning · Statistics 2012-06-08 Ali Jalali , Sujay Sanghavi

This paper considers optimization problems over networks where agents have individual objectives to meet, or individual parameter vectors to estimate, subject to subspace constraints that require the objectives across the network to lie in…

Multiagent Systems · Computer Science 2020-04-22 Roula Nassif , Stefan Vlaski , Ali H. Sayed

Sparse training is emerging as a promising avenue for reducing the computational cost of training neural networks. Several recent studies have proposed pruning methods using learnable thresholds to efficiently explore the non-uniform…

Machine Learning · Computer Science 2023-04-17 Abhisek Kundu , Naveen K. Mellempudi , Dharma Teja Vooturi , Bharat Kaul , Pradeep Dubey

Pruning has emerged as a promising approach for compressing large-scale models, yet its effectiveness in recovering the sparsest of models has not yet been explored. We conducted an extensive series of 485,838 experiments, applying a range…

Machine Learning · Computer Science 2024-07-08 Stephen Zhang , Vardan Papyan

We consider the problem of selecting $k$ seed nodes in a network to maximize the minimum probability of activation under an independent cascade beginning at these seeds. The motivation is to promote fairness by ensuring that even the least…

Social and Information Networks · Computer Science 2025-02-20 Dennis Robert Windham , Caroline J. Wendt , Alex Crane , Madelyn J Warr , Freda Shi , Sorelle A. Friedler , Blair D. Sullivan , Aaron Clauset

Recent work on deep neural network pruning has shown there exist sparse subnetworks that achieve equal or improved accuracy, training time, and loss using fewer network parameters when compared to their dense counterparts. Orthogonal to…

Machine Learning · Computer Science 2019-12-06 Justin Cosentino , Federico Zaiter , Dan Pei , Jun Zhu

Obtaining versions of deep neural networks that are both highly-accurate and highly-sparse is one of the main challenges in the area of model compression, and several high-performance pruning techniques have been investigated by the…

Machine Learning · Computer Science 2023-09-11 Denis Kuznedelev , Eldar Kurtic , Eugenia Iofinova , Elias Frantar , Alexandra Peste , Dan Alistarh

The SparseStep algorithm is presented for the estimation of a sparse parameter vector in the linear regression problem. The algorithm works by adding an approximation of the exact counting norm as a constraint on the model parameters and…

Methodology · Statistics 2017-01-25 Gerrit J. J. van den Burg , Patrick J. F. Groenen , Andreas Alfons

The explosion of large-scale data in fields such as finance, e-commerce, and social media has outstripped the processing capabilities of single-machine systems, driving the need for distributed statistical inference methods. Traditional…

Machine Learning · Statistics 2024-09-02 Jingguo Lan , Hongmei Lin , Xueqin Wang

Deep learning has powered recent successes of artificial intelligence (AI). However, the deep neural network, as the basic model of deep learning, has suffered from issues such as local traps and miscalibration. In this paper, we provide a…

Machine Learning · Statistics 2021-12-03 Yan Sun , Wenjun Xiong , Faming Liang

Although sparse neural networks have been studied extensively, the focus has been primarily on accuracy. In this work, we focus instead on network structure, and analyze three popular algorithms. We first measure performance when structure…

Machine Learning · Computer Science 2020-12-02 Maxwell Van Gelder , Mitchell Wortsman , Kiana Ehsani

We develop a method for reconstructing regulatory interconnection networks between variables evolving according to a linear dynamical system. The work is motivated by the problem of gene regulatory network inference, that is, finding causal…

Methodology · Statistics 2018-02-19 Atte Aalto , Jorge Goncalves

In the Network Inference problem, one seeks to recover the edges of an unknown graph from the observations of cascades propagating over this graph. In this paper, we approach this problem from the sparse recovery perspective. We introduce a…

Social and Information Networks · Computer Science 2024-11-14 Jean Pouget-Abadie , Thibaut Horel

Many modern big data applications feature large scale in both numbers of responses and predictors. Better statistical efficiency and scientific insights can be enabled by understanding the large-scale response-predictor association network…

Methodology · Statistics 2017-04-28 Yoshimasa Uematsu , Yingying Fan , Kun Chen , Jinchi Lv , Wei Lin

Gaussian processes (GPs) are a powerful tool for probabilistic inference over functions. They have been applied to both regression and non-linear dimensionality reduction, and offer desirable properties such as uncertainty estimates,…

Machine Learning · Statistics 2014-10-01 Yarin Gal , Mark van der Wilk , Carl E. Rasmussen

Deep neural networks have long been criticized for being black-box. To unveil the inner workings of modern neural architectures, a recent work \cite{yu2024white} proposed an information-theoretic objective function called Sparse Rate…

Machine Learning · Computer Science 2024-11-27 Yunzhe Hu , Difan Zou , Dong Xu
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