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RNA structure determination is essential for understanding its biological functions. However, the reconstruction process often faces challenges, such as atomic clashes, which can lead to inaccurate models. To address these challenges, we…

Biomolecules · Quantitative Biology 2026-03-04 Menghao Wu , Zhigang Yao

DNA Data storage has recently attracted much attention due to its durable preservation and extremely high information density (bits per gram) properties. In this work, we propose a hybrid coding strategy comprising of generalized…

Information Theory · Computer Science 2021-12-20 Yixin Wang , Li Deng , Md. Noor-A-Rahim , Erry Gunawan , Yong L. Guan , Zhi P. Shi , Chueh L. Poh

To learn accurate representations of molecules, it is essential to consider both chemical and geometric features. To encode geometric information, many descriptors have been proposed in constrained circumstances for specific types of…

Machine Learning · Computer Science 2023-07-25 Shuo Zhang , Yang Liu , Li Xie , Lei Xie

Decomposing hypergraphs is a key task in hypergraph analysis with broad applications in community detection, pattern discovery, and task scheduling. Existing approaches such as $k$-core and neighbor-$k$-core rely on vertex degree…

Social and Information Networks · Computer Science 2026-04-10 Xiaoyu Leng , Hongchao Qin , Rong-Hua Li

In this paper, we propose and test a novel diagonal sweeping domain decomposition method (DDM) with source transfer for solving the high-frequency Helmholtz equation in $\mathbb{R}^n$. In the method the computational domain is partitioned…

Numerical Analysis · Mathematics 2020-09-02 Wei Leng , Lili Ju

Earlier formulations of the DNA assembly problem were all in the context of perfect assembly; i.e., given a set of reads from a long genome sequence, is it possible to perfectly reconstruct the original sequence? In practice, however, it is…

Information Theory · Computer Science 2016-05-09 Ilan Shomorony , Govinda M. Kamath , Fei Xia , Thomas A. Courtade , David N. Tse

With the prevalence of graphs for modeling complex relationships among objects, the topic of graph mining has attracted a great deal of attention from both academic and industrial communities in recent years. As one of the most fundamental…

Social and Information Networks · Computer Science 2026-04-21 Wensheng Luo , Chenhao Ma , Yixiang Fang , Laks V. S. Lakshmanan

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi

Graph Neural Networks (GNNs) have shown superior performance for semi-supervised learning of numerous web applications, such as classification on web services and pages, analysis of online social networks, and recommendation in e-commerce.…

Social and Information Networks · Computer Science 2023-06-06 Keke Huang , Jing Tang , Juncheng Liu , Renchi Yang , Xiaokui Xiao

DNA is not only the genetic material of life, but also a favorable material for a new computing model. Various research works based on DNA computing have been carried out in recent years. DNA sequence design is the foundation of such…

Emerging Technologies · Computer Science 2023-11-10 Yao Yao , Xun Zhang , Xin Liu , Yuan Liu , Xiaokang Zhang , Qiang Zhang

The theory of computer science is based around Universal Turing Machines (UTMs): abstract machines able to execute all possible algorithms. Modern digital computers are physical embodiments of UTMs. The nondeterministic polynomial (NP) time…

Computational Complexity · Computer Science 2016-08-02 Andrew Currin , Konstantin Korovin , Maria Ababi , Katherine Roper , Douglas B. Kell , Philip J. Day , Ross D. King

Convolutional neural networks are the way to solve arbitrary image segmentation tasks. However, when images are large, memory demands often exceed the available resources, in particular on a common GPU. Especially in biomedical imaging,…

Computer Vision and Pattern Recognition · Computer Science 2022-06-08 Marco Reisert , Maximilian Russe , Samer Elsheikh , Elias Kellner , Henrik Skibbe

Motivation: With the development of droplet based systems, massive single cell transcriptome data has become available, which enables analysis of cellular and molecular processes at single cell resolution and is instrumental to…

Machine Learning · Computer Science 2018-12-27 Tiehang Duan , José P. Pinto , Xiaohui Xie

In this paper, a deep collocation method (DCM) for thin plate bending problems is proposed. This method takes advantage of computational graphs and backpropagation algorithms involved in deep learning. Besides, the proposed DCM is based on…

Numerical Analysis · Mathematics 2021-05-27 Hongwei Guo , Xiaoying Zhuang , Timon Rabczuk

A hypercomplex representation of DNA is proposed to facilitate comparison of DNA sequences with fuzzy composition. Using hypercomplex number representation, conventional sequence analysis method, such as, dot matrix analysis, dynamic…

Quantitative Methods · Quantitative Biology 2023-08-03 Jian-Jun Shu , Yajing Li

Due to their sequential nature, traditional DNA synthesis methods are expensive in terms of time and resources. They also fabricate multiple copies of the same strand, introducing redundancy. This redundancy can be leveraged to enhance the…

Information Theory · Computer Science 2025-10-29 Frederik Walter , Yonatan Yehezkeally

Recent advances in next-generation sequencing technologies have facilitated the use of deoxyribonucleic acid (DNA) as a novel covert channels in steganography. There are various methods that exist in other domains to detect hidden messages…

Machine Learning · Computer Science 2018-10-08 Ho Bae , Byunghan Lee , Sunyoung Kwon , Sungroh Yoon

This paper considers a general data-fitting problem over a networked system, in which many computing nodes are connected by an undirected graph. This kind of problem can find many real-world applications and has been studied extensively in…

Machine Learning · Computer Science 2017-04-14 Ying Zhang

DNA emerges as a promising medium for the exponential growth of digital data due to its density and durability. This study extends recent research by addressing the \emph{coverage depth problem} in practical scenarios, exploring optimal…

Information Theory · Computer Science 2024-02-01 Hadas Abraham , Rayn Gabrys , Eitan Yaakobi

Subgraph matching is a core task in graph analytics, widely used in domains such as biology, finance, and social networks. Existing top-k diversified methods typically focus on maximizing vertex coverage, but often return results in the…

Databases · Computer Science 2025-11-25 Liuyi Chen , Yuchen Hu , Zhengyi Yang , Xu Zhou , Wenjie Zhang , Kenli Li