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Efficiently solving NP-complete problems-such as protein structure prediction, cryptographic decryption, and vulnerability detection-remains a central challenge in computer science. Traditional electronic computers, constrained by the…

Data Structures and Algorithms · Computer Science 2025-07-18 Jin Xu , XiaoLong Shi , Xin Chen , Fang Wang , Sirui Li , Pali Ye , Boliang Zhang , Di Deng , Zheng Kou , Xiaoli Qiang

Although it has been evidenced that DNA computing is able to solve the graph coloring problem in a polynomial time complexity, but the exponential solution space is still a restrictive factor in applying this technique for solving really…

Computational Complexity · Computer Science 2013-04-15 Ramin Maazallahi , Aliakbar Niknafs

Adleman showed that deoxyribonucleic acid DNA strands could be employed towards calculating solutions to an instance of the Hamiltonian path problem . Lipton also demonstrated that Adleman techniques could be used to solve the…

Data Structures and Algorithms · Computer Science 2016-11-10 Akbar Moazzam , Babak Dalvand

Dense subgraph discovery methods are routinely used in a variety of applications including the identification of a team of skilled individuals for collaboration from a social network. However, when the network's node set is associated with…

Social and Information Networks · Computer Science 2023-06-06 Atsushi Miyauchi , Tianyi Chen , Konstantinos Sotiropoulos , Charalampos E. Tsourakakis

DNA-based storage offers unprecedented density and durability, but its scalability is fundamentally limited by the efficiency of parallel strand synthesis. Existing methods either allow unconstrained nucleotide additions to individual…

Information Theory · Computer Science 2025-10-27 Boaz Moav , Ryan Gabrys , Eitan Yaakobi

Several technological limitations of traditional silicon based computing are leading towards the paradigm shift, from silicon to carbon, in computational world. Among the unconventional modes of computing evolved in past several decades,…

Biomolecules · Quantitative Biology 2020-10-02 Mandrita Mondal , Kumar S. Ray

This paper proposes a deep-learning-based domain decomposition method (DeepDDM), which leverages deep neural networks (DNN) to discretize the subproblems divided by domain decomposition methods (DDM) for solving partial differential…

Numerical Analysis · Mathematics 2020-04-13 Wuyang Li , Xueshuang Xiang , Yingxiang Xu

Semiparametric statistics play a pivotal role in a wide range of domains, including but not limited to missing data, causal inference, and transfer learning, to name a few. In many settings, semiparametric theory leads to (nearly)…

Machine Learning · Statistics 2024-08-06 Qinshuo Liu , Zixin Wang , Xi-An Li , Xinyao Ji , Lei Zhang , Lin Liu , Zhonghua Liu

Double-strand DNA breaks (DSBs) are a form of DNA damage that can cause abnormal chromosomal rearrangements. Recent technologies based on high-throughput experiments have obvious high costs and technical challenges.Therefore, we design a…

Quantitative Methods · Quantitative Biology 2022-01-07 XU Wang , Huan Zhao , Weiwei TU , Hao Li , Yu Sun , Xiaochen Bo

Deep neural networks (DNNs) and, in particular, convolutional neural networks (CNNs) have brought significant advances in a wide range of modern computer application problems. However, the increasing availability of large amounts of…

Machine Learning · Computer Science 2024-07-03 Axel Klawonn , Martin Lanser , Janine Weber

Reassembly tasks play a fundamental role in many fields and multiple approaches exist to solve specific reassembly problems. In this context, we posit that a general unified model can effectively address them all, irrespective of the input…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Gianluca Scarpellini , Stefano Fiorini , Francesco Giuliari , Pietro Morerio , Alessio Del Bue

DNA exhibits remarkable potential as a data storage solution due to its impressive storage density and long-term stability, stemming from its inherent biomolecular structure. However, developing this novel medium comes with its own set of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-14 Trung Hieu Le , Xavier Pic , Jeremy Mateos , Marc Antonini

DNA computing is an unconventional approach to computing that harnesses the parallelism and information storage capabilities of DNA molecules. It has emerged as a promising field with potential applications in solving a variety of…

Emerging Technologies · Computer Science 2024-06-04 Muhammad Asad Tariq , Rafay Junaid , Muhammad Mehdy Hasnain , Danyal Farhat

In order to formulate mathematical conjectures likely to be true, a number of base cases must be determined. However, many combinatorial problems are NP-hard and the computational complexity makes this research approach difficult using a…

Data Structures and Algorithms · Computer Science 2015-12-18 Victoria Horan , Steve Adachi , Stanley Bak

The problem of assembling DNA fragments starting from imperfect strings given by a sequencer, classified as NP hard when trying to get perfect answers, has a huge importance in several fields, because of its relation with the possibility of…

Data Structures and Algorithms · Computer Science 2017-05-26 Juan Manuel Ciro Restrepo , Andrés Felipe Zapata Palacio , Mauricio Toro

In the current era, DeoxyriboNucleic Acid (DNA) based data storage emerges as an intriguing approach, garnering substantial academic interest and investigation. This paper introduces a novel deep joint source-channel coding (DJSCC) scheme…

Emerging Technologies · Computer Science 2023-11-03 Wenfeng Wu , Luping Xiang , Qiang Liu , Kun Yang

Graph coloring involves assigning colors to the vertices of a graph such that two vertices linked by an edge receive different colors. Graph coloring problems are general models that are very useful to formulate many relevant applications…

Machine Learning · Computer Science 2020-10-27 Olivier Goudet , Béatrice Duval , Jin-Kao Hao

Many real-world networks can be modeled as graphs. Finding dense subgraphs is a key problem in graph mining with applications in diverse domains. In this paper, we consider two variants of the densest subgraph problem where multiple graph…

Data Structures and Algorithms · Computer Science 2025-02-04 Chamalee Wickrama Arachchi , Nikolaj Tatti

Surrogate neural network-based partial differential equation (PDE) solvers have the potential to solve PDEs in an accelerated manner, but they are largely limited to systems featuring fixed domain sizes, geometric layouts, and boundary…

Machine Learning · Computer Science 2025-01-10 Chenkai Mao , Robert Lupoiu , Tianxiang Dai , Mingkun Chen , Jonathan A. Fan

Because of several technological limitations of traditional silicon based computing, for past few years a paradigm shift, from silicon to carbon, is occurring in computational world. DNA computing has been considered to be quite promising…

Artificial Intelligence · Computer Science 2017-02-20 Kumar S. Ray , Mandrita Mondal
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