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The proteins involved in cells' mechanobiological processes have evolved specialized and surprising responses to applied forces. Biochemical transformations that show catch-to-slip switching and force-induced pathway switching serve…

Biomolecules · Quantitative Biology 2024-08-26 Casey O. Barkan , Robijn F. Bruinsma

We show that when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For inter-cellular coupling that implements lateral inhibition,…

Tissues and Organs · Quantitative Biology 2023-01-10 Chandrashekar Kuyyamudi , Shakti N. Menon , Sitabhra Sinha

We investigate a phase transition from linear to nonlinear information processing in echo state networks, a widely used framework in reservoir computing. The network consists of randomly connected recurrent nodes perturbed by a noise and…

Disordered Systems and Neural Networks · Physics 2025-11-25 Masaya Matsumura , Taiki Haga

Localized receptive fields -- neurons that are selective for certain contiguous spatiotemporal features of their input -- populate early sensory regions of the mammalian brain. Unsupervised learning algorithms that optimize explicit…

Machine Learning · Computer Science 2025-01-30 Leon Lufkin , Andrew M. Saxe , Erin Grant

Demixing of binary liquids is a ubiquitous transition, which is explained using a well-established thermodynamic formalism that requires equality of intensive thermodynamics parameters across the phase boundaries. Demixing transitions also…

We propose a novel method to reconstruct phase dynamics equations from responses in macroscopic variables to weak inputs. Developing linear and nonlinear response theories in coupled phase-oscillators, we derive formulae which connect the…

Adaptation and Self-Organizing Systems · Physics 2023-01-06 Yoshiyuki Y. Yamaguchi , Yu Terada

We experimentally investigate a nonlinear switching mechanism in a dual-core highly nonlinear optical fiber. We focus the input beam of femtosecond pulses on one core only, to identify transitions between inter-core oscillations,…

Experimental evidence shows that there is a feedback between cell shape and cell motion. How this feedback impacts the collective behavior of dense cell monolayers remains an open question. We investigate the effect of a feedback that tends…

Intense laser technologies generate light with unprecedented and growing intensities. The possibility emerges that a nucleus responds nonlinearly to an intense light field, pointing to a yet little explored research area of nuclear…

Atomic Physics · Physics 2021-09-01 Tao Li , Xu Wang

In an earlier work (R. Bhandari, Phys. Lett. A 204 (1995) 188), it was shown that, contrary to the property of achromaticity (independence of wavelength) usually associated with topological phases, topological phases encountered in…

Optics · Physics 2007-05-23 Rajendra Bhandari

Phase transitions in equilibrium and nonequilibrium systems play a major role in the natural sciences. In dynamical networks, phase transitions organize qualitative changes in the collective behavior of coupled dynamical units. Adaptive…

Adaptation and Self-Organizing Systems · Physics 2023-02-22 Jan Fialkowski , Serhiy Yanchuk , Igor M. Sokolov , Eckehard Schöll , Georg A. Gottwald , Rico Berner

Nucleation of a new phase almost always starts at a surface. This surface is almost always assumed not to change with time. However, surfaces can roughen, partially dissolve and change chemically with time. Each of these irreversible…

Soft Condensed Matter · Physics 2015-03-25 Richard P. Sear

Single-cell studies often show significant phenotypic variability due to the stochastic nature of intra-cellular biochemical reactions. When the numbers of molecules, e.g., transcription factors and regulatory enzymes, are in low abundance,…

Quantitative Methods · Quantitative Biology 2015-06-17 Kyung Hyuk Kim , Hong Qian , Herbert M. Sauro

Circuits provide ideal platforms of topological phases and matter, yet the study of topological circuits in the strongly nonlinear regime, has been lacking. We propose and experimentally demonstrate strongly nonlinear topological phases and…

Mesoscale and Nanoscale Physics · Physics 2023-07-03 Jijie Tang , Fangyuan Ma , Feng Li , Honglian Guo , Di Zhou

Cell motility is one of the most fundamental phenomena underlying biological processes that maintain living organisms alive. Here we introduce a simple model to describe the motility of cells which include not only time-correlated internal…

Biological Physics · Physics 2022-07-13 T. N. Azevedo , L. G. Rizzi

While the phase of a coherent light field can be precisely known, the phase of the individual photons that create this field, considered individually, cannot. Phase changes within single-photon wave packets, however, have observable…

Quantum Physics · Physics 2009-08-07 H. P. Specht , J. Bochmann , M. Muecke , B. Weber , E. Figueroa , D. L. Moehring , G. Rempe

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…

Biological Physics · Physics 2015-04-02 A. -K. Gustavsson , C. B. Adiels , B. Mehlig , M. Goksör

Current fluctuations in pure lipid membranes have been shown to occur under the influence of transmembrane electric fields (electroporation) as well as a result from structural rearrangements of the lipid bilayer during phase transition…

Biological Physics · Physics 2015-05-13 B. Wunderlich , C . Leirer , A-L. Idzko , U. F. Keyser , A. Wixforth , V. M. Myles , T. Heimburg , M. F. Schneider

We study an active random walker model in which a particle's motion is determined by a self-generated field. The field encodes information about the particle's path history. This leads to either self-attractive or self-repelling behavior.…

Statistical Mechanics · Physics 2009-11-11 R. Grima

Mechanical metamaterials are periodic lattice structures with complex unit cell architectures that can achieve extraordinary mechanical properties beyond the capability of bulk materials. A new class of metamaterials is proposed, whose…

Applied Physics · Physics 2022-07-22 Marius Wagner , Fabian Schwarz , Nick Huber , Lena Geistlich , Henning Galinski , Ralph Spolenak
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