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The minimum description length (MDL) principle states that the best model to account for some data minimizes the sum of the lengths, in bits, of the descriptions of the model and the residual error. The description length is thus a…

Quantitative Methods · Quantitative Biology 2015-07-21 Peter T. Hraber , Bette T. Korber , Steven Wolinsky , Henry A. Erlich , Elizabeth A. Trachtenberg , Thomas B. Kepler

Modern data acquisition routinely produce massive amounts of event sequence data in various domains, such as social media, healthcare, and financial markets. These data often exhibit complicated short-term and long-term temporal…

Machine Learning · Computer Science 2021-02-23 Simiao Zuo , Haoming Jiang , Zichong Li , Tuo Zhao , Hongyuan Zha

Anomaly detection is a fundamental yet challenging problem in machine learning due to the lack of label information. In this work, we propose a novel and powerful framework, dubbed as SLA$^2$P, for unsupervised anomaly detection. After…

Machine Learning · Computer Science 2021-11-29 Yizhou Wang , Can Qin , Rongzhe Wei , Yi Xu , Yue Bai , Yun Fu

The widespread application of machine learning techniques to biomedical data has produced many new insights into disease progression and improving clinical care. Inspired by the flexibility and interpretability of graphs (networks), as well…

Machine Learning · Computer Science 2023-12-27 Steven J. Krieg , Nitesh V. Chawla , Keith Feldman

Medical tabular data, abundant in Electronic Health Records (EHRs), is a valuable resource for diverse medical tasks such as risk prediction. While deep learning approaches, particularly transformer-based models, have shown remarkable…

Computation and Language · Computer Science 2025-04-11 Yucheng Ruan , Xiang Lan , Daniel J. Tan , Hairil Rizal Abdullah , Mengling Feng

DNA sequence alignment involves assigning short DNA reads to the most probable locations on an extensive reference genome. This process is crucial for various genomic analyses, including variant calling, transcriptomics, and epigenomics.…

Recently, deep learning models have achieved excellent performance in hyperspectral image (HSI) classification. Among the many deep models, Transformer has gradually attracted interest for its excellence in modeling the long-range…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Lingbo Huang , Yushi Chen , Xin He

The emerging research shows that lncRNA has crucial research value in a series of complex human diseases. Therefore, the accurate identification of lncRNA-disease associations (LDAs) is very important for the warning and treatment of…

Machine Learning · Computer Science 2024-06-06 Wen-Yu Xi , Juan Wang , Yu-Lin Zhang , Jin-Xing Liu , Yin-Lian Gao

Sequence-to-sequence models have become central in Artificial Intelligence, particularly following the introduction of the transformer architecture. While initially developed for Natural Language Processing, these models have demonstrated…

Machine Learning · Computer Science 2025-10-03 Daniel Gallo Fernández

Liver diseases are a serious health concern in the world, which requires precise and timely diagnosis to enhance the survival chances of patients. The current literature implemented numerous machine learning and deep learning models to…

Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine,…

Machine Learning · Computer Science 2026-05-05 Hongxi Mao , Wei Zhou , Mengting Jia , Tao Fang , Huan Gao , Bin Zhang , Shangyang Li

Transformer-based large language models (LLM) have been widely used in language processing applications. However, due to the memory constraints of the devices, most of them restrict the context window. Even though recurrent models in…

Computation and Language · Computer Science 2025-02-07 Zifan He , Yingqi Cao , Zongyue Qin , Neha Prakriya , Yizhou Sun , Jason Cong

Recurrent Neural Networks were, until recently, one of the best ways to capture the timely dependencies in sequences. However, with the introduction of the Transformer, it has been proven that an architecture with only attention-mechanisms…

Machine Learning · Computer Science 2021-08-19 Radostin Cholakov , Todor Kolev

A challenging part of dynamic probabilistic risk assessment for nuclear power plants is the need for large amounts of temporal simulations given various initiating events and branching conditions from which representative feature extraction…

Machine Learning · Computer Science 2021-04-20 Bing Zha , Alessandro Vanni , Yassin Hassan , Tunc Aldemir , Alper Yilmaz

Numerous diseases, particularly autoimmune disorders, are associated with the human leukocyte antigen (HLA), a small genomic region located on human chromosome 6. Adequate characterization of linkage disequilibrium (LD) in the HLA across…

Genomics · Quantitative Biology 2025-12-08 Fei Zhang , Weixiong Zhang

Recombination is an important event in the evolution of HIV. It affects the global spread of the pandemic as well as evolutionary escape from host immune response and from drug therapy within single patients. Comprehensive computational…

Genomics · Quantitative Biology 2007-05-23 Niko Beerenwinkel , Colin N. Dewey , Kevin M. Woods

Language models have advanced sequence analysis, yet DNA foundation models often lag behind task-specific methods for unclear reasons. We present AntigenLM, a generative DNA language model pretrained on influenza genomes with intact,…

Genomics · Quantitative Biology 2026-02-12 Yue Pei , Xuebin Chi , Yu Kang

We present a parallel algorithm and scalable implementation for genome analysis, specifically the problem of finding overlaps and alignments for data from "third generation" long read sequencers. While long sequences of DNA offer enormous…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-01-29 Marquita Ellis , Giulia Guidi , Aydın Buluç , Leonid Oliker , Katherine Yelick

Transfer learning through fine-tuning a pre-trained neural network with an extremely large dataset, such as ImageNet, can significantly accelerate training while the accuracy is frequently bottlenecked by the limited dataset size of the new…

Machine Learning · Computer Science 2020-05-14 Xingjian Li , Haoyi Xiong , Hanchao Wang , Yuxuan Rao , Liping Liu , Zeyu Chen , Jun Huan

In real world clinical environments, training and applying deep learning models on multi-modal medical imaging data often struggles with partially incomplete data. Standard approaches either discard missing samples, require imputation or…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Christoph Fürböck , Paul Weiser , Branko Mitic , Philipp Seeböck , Thomas Helbich , Georg Langs
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