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Associated with a chemical reaction network is a natural labelled bipartite multigraph termed an SR graph, and its directed version, the DSR graph. These objects are closely related to Petri nets. The construction of SR and DSR graphs for…

Dynamical Systems · Mathematics 2010-07-22 Murad Banaji

Robustness is an observable property for which a chemical reaction network (CRN) can maintain its functionalities despite the influence of different perturbations. In general, to verify whether a network is robust, it is necessary to…

Formal Languages and Automata Theory · Computer Science 2021-04-29 Lucia Nasti , Roberta Gori , Paolo Milazzo

Conservation laws are time-invariant properties that constrain many physical systems. For systems of chemical reactions, the law of mass conservation constrains how atoms flow between chemical species. Chemical reaction networks can display…

Atmospheric and Oceanic Physics · Physics 2026-05-27 Beatriz Lucia G. Rodriguez , Patrick Obin Sturm , Daniel Getter , Sam J. Silva

We initiate the study of rate-constant-independent computation of Boolean predicates and numerical functions in the continuous model of chemical reaction networks (CRNs), which model the amount of a chemical species as a nonnegative,…

Computational Complexity · Computer Science 2025-06-10 Kim Calabrese , David Doty , Mina Latifi

To understand the fundamental trade-offs between training stability, temporal dynamics and architectural complexity of recurrent neural networks~(RNNs), we directly analyze RNN architectures using numerical methods of ordinary differential…

Machine Learning · Computer Science 2019-05-01 Murphy Yuezhen Niu , Lior Horesh , Isaac Chuang

Linearized catalytic reaction equations modeling e.g. the dynamics of genetic regulatory networks under the constraint that expression levels, i.e. molecular concentrations of nucleic material are positive, exhibit nontrivial dynamical…

Disordered Systems and Neural Networks · Physics 2015-05-18 Rudolf Hanel , Manfred Pöchacker , Stefan Thurner

In this work, a family of finite volume discretization schemes for LWR-type first order traffic flow models (with possible on- and off-ramps) is proposed: the Traffic Reaction Model (TRM). These schemes yield systems of ODEs that are…

Numerical Analysis · Mathematics 2024-01-03 M. Pereira , B. Kulcsár , Gy. Lipták , M. Kovács , G. Szederkényi

Dynamical systems containing heteroclinic cycles and networks can be invoked as models of intransitive competition between three or more species. When populations are assumed to be well-mixed, a system of ordinary differential equations…

Dynamical Systems · Mathematics 2023-11-01 David C Groothuizen Dijkema , Claire M Postlethwaite

Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical model for the evolution of an idealized chemical system to study how a network of…

Adaptation and Self-Organizing Systems · Physics 2014-03-05 Sanjay Jain , Sandeep Krishna

Chemical oscillation is an interesting nonlinear dynamical phenomenon which arises due to complex stability condition of the steady state of a reaction far away from equilibrium which is usually characterised by a periodic attractor or a…

Dynamical Systems · Mathematics 2018-11-13 Sandip Saha , Gautam Gangopadhyay

Kinetic theory and thermodynamics of reaction networks are extended to the out-of-equilibrium dynamics of continuous-flow stirred tank reactors (CSTR) and serial transfers. On the basis of their stoichiometry matrix, the conservation laws…

Statistical Mechanics · Physics 2018-04-24 Alex Blokhuis , David Lacoste , Pierre Gaspard

Stochastic Chemical Reaction Networks are continuous time Markov chain models that describe the time evolution of the molecular counts of species interacting stochastically via discrete reactions. Such models are ubiquitous in systems and…

Quantitative Methods · Quantitative Biology 2024-02-01 Theodore W. Grunberg , Domitilla Del Vecchio

We develop a general classification of the nature of the instabilities yielding spatial organization in open nonideal reaction-diffusion systems, based on linear stability analysis. This encompasses dynamics where chemical species diffuse,…

Statistical Mechanics · Physics 2023-10-05 Timur Aslyamov , Francesco Avanzini , Étienne Fodor , Massimiliano Esposito

Reversibility, weak reversibility and deficiency, detailed and complex balancing are generally not "encoded" in the kinetic differential equations but they are realization properties that may imply local or even global asymptotic stability…

Molecular Networks · Quantitative Biology 2011-05-11 Gabor Szederkenyi , Katalin M. Hangos

An algorithm is given in this paper for the computation of dynamically equivalent weakly reversible realizations with the maximal number of reactions, for chemical reaction networks (CRNs) with mass action kinetics.

Dynamical Systems · Mathematics 2015-03-19 Gabor Szederkenyi , Katalin M. Hangos , Zsolt Tuza

Many real networks can be understood as two complementary networks with two kind of nodes. This is the case of metabolic networks where the first network has chemical compounds as nodes and the second one has nodes as reactions. The second…

Molecular Networks · Quantitative Biology 2007-05-23 J. C. Nacher , N. Ueda , T. Yamada , M. Kanehisa , T. Akutsu

Conserved quantities increasingly underpin the inference of physical models. Recently new conserved quantities have been found in this context, that currently lack an interpretation. Here, we show that irreversible reactions in CRNs and…

Statistical Mechanics · Physics 2026-05-08 Alex Blokhuis , Martijn van Kuppeveld , Daan van de Weem , Robert Pollice

Recent research in both the experimental and mathematical communities has focused on biochemical interaction systems that satisfy an "absolute concentration robustness" (ACR) property. The ACR property was first discovered experimentally…

Probability · Mathematics 2018-05-22 David F. Anderson , Daniele Cappelletti , Thomas G. Kurtz

The catalytic reaction system (CRS) formalism by Hordijk and Steel is a versatile method to model autocatalytic biochemical reaction networks. It is particularly suited, and has been widely used, to study self-sustainment and…

Molecular Networks · Quantitative Biology 2023-08-16 Dimitri Loutchko

Chemical reaction networks in living cells maintain precise control over thousands of metabolites despite operating far from equilibrium under constant perturbations. While mass action kinetics accurately describe the underlying dynamics,…

Optimization and Control · Mathematics 2025-08-27 Steven Diamond