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Computational Pangenomics is an emerging field that studies genetic variation using a graph structure encompassing multiple genomes. Visualizing pangenome graphs is vital for understanding genome diversity. Yet, handling large graphs can be…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-29 Jiajie Li , Jan-Niklas Schmelzle , Yixiao Du , Simon Heumos , Andrea Guarracino , Giulia Guidi , Pjotr Prins , Erik Garrison , Zhiru Zhang

RRAM-based multi-core systems improve the energy efficiency and performance of CNNs. Thereby, the distributed parallel execution of convolutional layers causes critical data dependencies that limit the potential speedup. This paper presents…

Hardware Architecture · Computer Science 2023-10-27 Rebecca Pelke , Nils Bosbach , Jose Cubero , Felix Staudigl , Rainer Leupers , Jan Moritz Joseph

Processing-in-DRAM (DRAM-PIM) has emerged as a promising technology for accelerating memory-intensive operations in modern applications, such as Large Language Models (LLMs). Despite its potential, current software stacks for DRAM-PIM face…

Hardware Architecture · Computer Science 2025-06-03 Yongwon Shin , Dookyung Kang , Hyojin Sung

The exponential growth of artificial intelligence (AI) applications has exposed the inefficiency of conventional von Neumann architectures, where frequent data transfers between compute units and memory create significant energy and latency…

Hardware Architecture · Computer Science 2026-03-18 James Read , Ming-Yen Lee , Wei-Hsing Huang , Yuan-Chun Luo , Anni Lu , Shimeng Yu

Digital processing-in-memory (PIM) architectures are rapidly emerging to overcome the memory-wall bottleneck by integrating logic within memory elements. Such architectures provide vast computational power within the memory itself in the…

Hardware Architecture · Computer Science 2023-04-18 Orian Leitersdorf , Dean Leitersdorf , Jonathan Gal , Mor Dahan , Ronny Ronen , Shahar Kvatinsky

Resistive Random Access Memory (RRAM) is an emerging device for processing-in-memory (PIM) architecture to accelerate convolutional neural network (CNN). However, due to the highly coupled crossbar structure in the RRAM array, it is…

Hardware Architecture · Computer Science 2020-10-14 Songming Yu , Yongpan Liu , Lu Zhang , Jingyu Wang , Jinshan Yue , Zhuqing Yuan , Xueqing Li , Huazhong Yang

The primary operation in DNNs is the dot product of quantized input activations and weights. Prior works have proposed the design of memory-centric architectures based on the Processing-In-Memory (PIM) paradigm. Resistive RAM (ReRAM)…

Hardware Architecture · Computer Science 2023-06-29 Mohammad Sabri , Marc Riera , Antonio González

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

Although adaptive optimization algorithms such as Adam show fast convergence in many machine learning tasks, this paper identifies a problem of Adam by analyzing its performance in a simple non-convex synthetic problem, showing that Adam's…

Machine Learning · Computer Science 2020-05-06 Wenjie Li , Zhaoyang Zhang , Xinjiang Wang , Ping Luo

Phase-change memory (PCM) devices have multiple banks to serve memory requests in parallel. Unfortunately, if two requests go to the same bank, they have to be served one after another, leading to lower system performance. We observe that a…

Hardware Architecture · Computer Science 2019-08-22 Shihao Song , Anup Das , Onur Mutlu , Nagarajan Kandasamy

Processing-in-Memory (PIM) enhances memory with computational capabilities, potentially solving energy and latency issues associated with data transfer between memory and processors. However, managing concurrent computation and data flow…

Hardware Architecture · Computer Science 2025-05-09 Ahmed Mamdouh , Haoran Geng , Michael Niemier , Xiaobo Sharon Hu , Dayane Reis

Processing-in-memory (PIM) architectures have seen an increase in popularity recently, as the high internal bandwidth available within 3D-stacked memory provides greater incentive to move some computation into the logic layer of the memory.…

Developing kernels for Processing-In-Memory (PIM) platforms poses unique challenges in data management and parallel programming on limited processing units. Although software development kits (SDKs) for PIM, such as the UPMEM SDK, provide…

Hardware Architecture · Computer Science 2025-10-21 Krystian Chmielewski , Jarosław Ławnicki , Uladzislau Lukyanau , Tadeusz Kobus , Maciej Maciejewski

Processing-using-DRAM (PUD) is a processing-in-memory (PIM) approach that uses a DRAM array's massive internal parallelism to execute very-wide data-parallel operations, in a single-instruction multiple-data (SIMD) fashion. However, DRAM…

Recently DRAM-based PIMs (processing-in-memories) with unmodified cell arrays have demonstrated impressive performance for accelerating AI applications. However, due to the very restrictive hardware constraints, PIM remains an accelerator…

Hardware Architecture · Computer Science 2023-10-17 Jaewoo Park , Sugil Lee , Jongeun Lee

Neural Radiance Fields (NeRF) offer significant promise for generating photorealistic images and videos. However, existing mainstream neural rendering models often fall short in meeting the demands for immediacy and power efficiency in…

Hardware Architecture · Computer Science 2025-08-05 Fangxin Liu , Haomin Li , Bowen Zhu , Zongwu Wang , Zhuoran Song , Habing Guan , Li Jiang

Decoder-only Transformer models such as GPT have demonstrated exceptional performance in text generation, by autoregressively predicting the next token. However, the efficacy of running GPT on current hardware systems is bounded by low…

Hardware Architecture · Computer Science 2024-04-16 Yuting Wu , Ziyu Wang , Wei D. Lu

Fully Homomorphic Encryption (FHE) imposes substantial memory bandwidth demands, presenting significant challenges for efficient hardware acceleration. Near-memory Processing (NMP) has emerged as a promising architectural solution to…

Hardware Architecture · Computer Science 2025-04-01 Shangyi Shi , Husheng Han , Jianan Mu , Xinyao Zheng , Ling Liang , Hang Lu , Zidong Du , Xiaowei Li , Xing Hu , Qi Guo

The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-27 Bertil Schmidt , Felix Kallenborn , Alexander Wichmann , Alejandro Chacon , Christian Hundt

Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes…

Genomics · Quantitative Biology 2018-05-02 Nathaniel McVicar , Akina Hoshino , Anna La Torre , Thomas A. Reh , Walter L. Ruzzo , Scott Hauck
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