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Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

Fluorescence spectroscopy is an image correlation technique to analyze and characterize the molecular dynamics from a sequence of fluorescence images. Many image correlation techniques have been developed for different applications [1]. But…

Quantitative Methods · Quantitative Biology 2017-10-24 C. Chen , P. Paul-Gilloteaux , T. Vignaud , J. Salamero , F. Waharte

Purpose: Intraoperative ultrasound scanning is a demanding visuotactile task. It requires operators to simultaneously localise the ultrasound perspective and manually perform slight adjustments to the pose of the probe, making sure not to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Alistair Weld , Luke Dixon , Giulio Anichini , Michael Dyck , Alex Ranne , Sophie Camp , Stamatia Giannarou

Clinical decision support using deep neural networks has become a topic of steadily growing interest. While recent work has repeatedly demonstrated that deep learning offers major advantages for medical image classification over traditional…

Image and Video Processing · Electrical Eng. & Systems 2022-06-10 Alexander Katzmann , Oliver Taubmann , Stephen Ahmad , Alexander Mühlberg , Michael Sühling , Horst-Michael Groß

Intraoperative fluorescent cardiac imaging enables quality control following coronary bypass grafting surgery. We can estimate local quantitative indicators, such as cardiac perfusion, by tracking local feature points. However, heart motion…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Suresh Guttikonda , Maximilian Neidhart , Johanna Sprenger , Johannes Petersen , Christian Detter , Alexander Schlaefer

This paper shows results of computer analysis of images in the purpose of finding differences between medical images in order of their classifications in terms of separation malign tissue from a normal and benign tissue. The diagnostics of…

Computer Vision and Pattern Recognition · Computer Science 2018-10-08 Jelena Vasiljević , Ivica Milosavljević , Vladimir Krstić , Nataša Zivić , Lazar Berbakov , Luka Lopušina , Dhinaharan Nagamalai , Milutin Cerović

Images are an important data source for diagnosis and treatment of oral diseases. The manual classification of images may lead to misdiagnosis or mistreatment due to subjective errors. In this paper an image classification model based on…

Computer Vision and Pattern Recognition · Computer Science 2017-05-26 Sultan Imangaliyev , Monique H. van der Veen , Catherine M. C. Volgenant , Bruno G. Loos , Bart J. F. Keijser , Wim Crielaard , Evgeni Levin

Deep learning based Computer Aided Diagnosis (CAD) systems have been developed to treat breast ultrasound. Most of them focus on a single ultrasound imaging modality, either using representative static images or the dynamic video of a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Yunwen Huang , Hongyu Hu , Ying Zhu , Yi Xu

Currently, free flaps and pedicled flaps are assessed for reperfusion in post-operative care using colour, capillary refill, temperature, texture and Doppler signal (if available). While these techniques are effective, they are prone to…

Medical Physics · Physics 2022-04-18 Mark Main , Richard JJ Pilkington , Graham M Gibson , Akhil Kallepalli

Given the crucial role of microtubules for cell survival, many researchers have found success using microtubule-targeting agents in the search for effective cancer therapeutics. Understanding microtubule responses to targeted interventions…

Image and Video Processing · Electrical Eng. & Systems 2019-10-03 Hao-Chih Lee , Sarah T Cherng , Riccardo Miotto , Joel T Dudley

Current methods for diagnosing the progression of multiple types of cancer within patients rely on interpreting stained needle biopsies. This process is time-consuming and susceptible to error throughout the paraffinization, Hematoxylin and…

Image and Video Processing · Electrical Eng. & Systems 2022-04-19 Benjamin Paulson , Theodore Colwell , Natalia Bukowski , Joseph Weller , Andrew Crisler , John Cisler , Alexander Drobek , Alexander Neuwirth

Optical imaging plays a critical role in advancing our understanding of three dimensional dynamics of biological systems. Coherent imaging (CI) methods exploit spatial phase information, encoded through propagation of coherent signal light…

Optics · Physics 2015-07-24 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI or perfusion-MRI plays an important role in the non-invasive assessment of tumor vascularity. However, the large number of images provided by the method makes display and…

General Physics · Physics 2007-11-20 Friso Hoefnagels , Keith S Cover , Ester Sanchez , Frank J. Lagerwaard

Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical…

Quantitative Methods · Quantitative Biology 2016-11-01 Longfei Li , R. J. Braun , W. D. Henshaw , P. E. King-Smith

Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining…

For early diagnosis of malignancies in the gastrointestinal tract, surveillance endoscopy is increasingly used to monitor abnormal tissue changes in serial examinations of the same patient. Despite successes with optical biopsy for in vivo…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Menglong Ye , Edward Johns , Benjamin Walter , Alexander Meining , Guang-Zhong Yang

Immunofluorescent (IF) imaging is crucial for visualizing biomarker expressions, cell morphology and assessing the effects of drug treatments on sub-cellular components. IF imaging needs extra staining process and often requiring cell…

Robotic surgery has been proven to offer clear advantages during surgical procedures, however, one of the major limitations is obtaining haptic feedback. Since it is often challenging to devise a hardware solution with accurate force…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Cong Gao , Xingtong Liu , Michael Peven , Mathias Unberath , Austin Reiter

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…

This research presents a machine-learning approach for tumor detection in medical images using convolutional neural networks (CNNs). The study focuses on preprocessing techniques to enhance image features relevant to tumor detection,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Ha Anh Vu