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Weakly-Supervised Semantic Segmentation (WSSS) segments objects without a heavy burden of dense annotation. While as a price, generated pseudo-masks exist obvious noisy pixels, which result in sub-optimal segmentation models trained over…

Computer Vision and Pattern Recognition · Computer Science 2021-12-15 Yi Li , Yiqun Duan , Zhanghui Kuang , Yimin Chen , Wayne Zhang , Xiaomeng Li

Magnetic resonance imaging (MRI) plays a vital role in the scientific investigation and clinical management of multiple sclerosis. Analyses of binary multiple sclerosis lesion maps are typically "mass univariate" and conducted with standard…

Deep Learning models are easily disturbed by variations in the input images that were not seen during training, resulting in unpredictable behaviours. Such Out-of-Distribution (OOD) images represent a significant challenge in the context of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Benjamin Lambert , Florence Forbes , Senan Doyle , Alan Tucholka , Michel Dojat

The accurate assessment of White matter hyperintensities (WMH) burden is of crucial importance for epidemiological studies to determine association between WMHs, cognitive and clinical data. The manual delineation of WMHs is tedious, costly…

Tissues and Organs · Quantitative Biology 2018-01-03 R. Guerrero , C. Qin , O. Oktay , C. Bowles , L. Chen , R. Joules , R. Wolz , M. C. Valdes-Hernandez , D. A. Dickie , J. Wardlaw , D. Rueckert

The evaluation of white matter lesion progression is an important biomarker in the follow-up of MS patients and plays a crucial role when deciding the course of treatment. Current automated lesion segmentation algorithms are susceptible to…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Mattias Billast , Maria Ines Meyer , Diana M. Sima , David Robben

Assessing lesions and tracking their progression over time in brain magnetic resonance (MR) images is essential for diagnosing and monitoring multiple sclerosis (MS). Machine learning models have shown promise in automating the segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Berke Doga Basaran , Paul M. Matthews , Wenjia Bai

Segmentation of white matter lesions and deep grey matter structures is an important task in the quantification of magnetic resonance imaging in multiple sclerosis. In this paper we explore segmentation solutions based on convolutional…

This work is motivated by a study of a population of multiple sclerosis (MS) patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to identify active brain lesions. At each visit, a contrast agent is administered…

Applications · Statistics 2013-06-25 Haochang Shou , Russell T. Shinohara , Han Liu , Daniel S. Reich , Ciprian M. Crainiceanu

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as…

Computer Vision and Pattern Recognition · Computer Science 2019-09-09 Hao Xiong , Chaoyue Wang , Dacheng Tao , Michael Barnett , Chenyu Wang

White Matter Hyperintensities (WMH) are key neuroradiological markers of small vessel disease present in brain MRI. Assessment of WMH is important in research and clinics. However, WMH are challenging to segment due to their high…

In this paper we describe and validate a longitudinal method for whole-brain segmentation of longitudinal MRI scans. It builds upon an existing whole-brain segmentation method that can handle multi-contrast data and robustly analyze images…

Computer Vision and Pattern Recognition · Computer Science 2023-02-13 Stefano Cerri , Douglas N. Greve , Andrew Hoopes , Henrik Lundell , Hartwig R. Siebner , Mark Mühlau , Koen Van Leemput

Magnetic resonance images (MRI) play an important role in supporting and substituting clinical information in the diagnosis of multiple sclerosis (MS) disease by presenting lesion in brain MR images. In this paper, an algorithm for MS…

Image and Video Processing · Electrical Eng. & Systems 2018-04-11 Saba Heidari Gheshlaghi , Abolfazl Madani , AmirAbolfazl Suratgar , Fardin Faraji

Lesion segmentation is a core task for quantitative analysis of MRI scans of Multiple Sclerosis patients. The recent success of deep learning techniques in a variety of medical image analysis applications has renewed community interest in…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Huahong Zhang , Ipek Oguz

The use of deep learning for medical imaging has seen tremendous growth in the research community. One reason for the slow uptake of these systems in the clinical setting is that they are complex, opaque and tend to fail silently. Outside…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Terrance DeVries , Graham W. Taylor

White matter hyperintensities (WMH) are a hallmark of cerebrovascular disease and multiple sclerosis. Automated WMH segmentation methods enable quantitative analysis via estimation of total lesion load, spatial distribution of lesions, and…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Xiaoling Hu , Annabel Sorby-Adams , Frederik Barkhof , W Taylor Kimberly , Oula Puonti , Juan Eugenio Iglesias

Automatic multiple sclerosis (MS) lesion segmentation using multi-contrast magnetic resonance (MR) images provides improved efficiency and reproducibility compared to manual delineation. Current state-of-the-art automatic MS lesion…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Jinwei Zhang , Lianrui Zuo , Blake E. Dewey , Samuel W. Remedios , Dzung L. Pham , Aaron Carass , Jerry L. Prince

Weakly-supervised learning (WSL) has recently triggered substantial interest as it mitigates the lack of pixel-wise annotations. Given global image labels, WSL methods yield pixel-level predictions (segmentations), which enable to interpret…

Computer Vision and Pattern Recognition · Computer Science 2021-10-12 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Purpose: Accurate segmentation of glioma subregions in multi-parametric MRI (MP-MRI) is essential for diagnosis and treatment planning but remains challenging due to tumor heterogeneity and ambiguous boundaries. This study proposes an…

Medical Physics · Physics 2025-07-22 Zhenyu Yang , Chen Yang , Rihui Zhang , Minbin Chen , Chunhao Wang , Fang-Fang Yin

Automated segmentation of multiple sclerosis (MS) lesions using multicontrast magnetic resonance (MR) images improves efficiency and reproducibility compared to manual delineation, with deep learning (DL) methods achieving state-of-the-art…