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Recent advances in neural-based generative modeling have reignited the hopes of having computer systems capable of conversing with humans and able to understand natural language. The employment of deep neural architectures has been largely…

Computation and Language · Computer Science 2022-11-16 Haoqin Tu , Yitong Li

Ligand-based virtual screening (VS) is an essential step in drug discovery that evaluates large chemical libraries to identify compounds that potentially bind to a therapeutic target. However, VS faces three major challenges: class…

Machine Learning · Computer Science 2026-01-22 Xin Wang , Yu Wang , Yunchao Liu , Jens Meiler , Tyler Derr

Detecting navigable space is the first and also a critical step for successful robot navigation. In this work, we treat the visual navigable space segmentation as a scene decomposition problem and propose a new network, NSS-VAEs (Navigable…

Robotics · Computer Science 2021-11-03 Zheng Chen , Lantao Liu

Representing graph data in a low-dimensional space for subsequent tasks is the purpose of attributed graph embedding. Most existing neural network approaches learn latent representations by minimizing reconstruction errors. Rare work…

Machine Learning · Computer Science 2024-01-15 Bozhen Hu , Zelin Zang , Jun Xia , Lirong Wu , Cheng Tan , Stan Z. Li

Generative artificial intelligence has revolutionized the exploration of chemical space, yet a critical bottleneck remains that a substantial fraction of generated molecules is synthetically inaccessible. Current solutions, such as post-hoc…

Artificial Intelligence · Computer Science 2025-12-24 Junren Li , Luhua Lai

Graphs serve as versatile data structures in numerous real-world domains-including social networks, molecular biology, and knowledge graphs-by capturing intricate relational information among entities. Among graph-based learning techniques,…

Machine Learning · Computer Science 2025-05-21 Chou-Ying Hsieh , Chun-Fu Jang , Cheng-En Hsieh , Qian-Hui Chen , Sy-Yen Kuo

Query rewriting is pivotal for enhancing dense retrieval, yet current methods demand large-scale supervised data or suffer from inefficient reinforcement learning (RL) exploration. In this work, we first establish that guiding Large…

Artificial Intelligence · Computer Science 2025-07-29 Teng Wang , Hailei Gong , Changwang Zhang , Jun Wang

The ability to discover meaningful, accurate, and concise mathematical equations that describe datasets is valuable across various domains. Equations offer explicit relationships between variables, enabling deeper insights into underlying…

Machine Learning · Computer Science 2025-04-01 Nisal Ranasinghe , Damith Senanayake , Saman Halgamuge

Integrating textual graphs into Large Language Models (LLMs) is promising for complex graph-based QA. However, a key bottleneck is retrieving informative yet compact subgraphs that fit the LLM context. Existing retrievers often struggle,…

Computation and Language · Computer Science 2026-04-23 Ge Chang , Jinbo Su , Jiacheng Liu , Pengfei Yang , Yuhao Shang , Huiwen Zheng , Hongli Ma , Yan Liang , Yuanchun Li , Yunxin Liu

We present a new supervised learning technique for the Variational AutoEncoder (VAE) that allows it to learn a causally disentangled representation and generate causally disentangled outcomes simultaneously. We call this approach Causally…

Machine Learning · Statistics 2023-10-10 Seunghwan An , Kyungwoo Song , Jong-June Jeon

Constructing powerful generative models for natural images is a challenging task. PixelCNN models capture details and local information in images very well but have limited receptive field. Variational autoencoders with a factorial decoder…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Hossein Sadeghi , Evgeny Andriyash , Walter Vinci , Lorenzo Buffoni , Mohammad H. Amin

Scene Graph Generation, which generally follows a regular encoder-decoder pipeline, aims to first encode the visual contents within the given image and then parse them into a compact summary graph. Existing SGG approaches generally not only…

Computer Vision and Pattern Recognition · Computer Science 2022-04-05 Xingning Dong , Tian Gan , Xuemeng Song , Jianlong Wu , Yuan Cheng , Liqiang Nie

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao

The generation of virtual populations (VPs) of anatomy is essential for conducting in silico trials of medical devices. Typically, the generated VP should capture sufficient variability while remaining plausible and should reflect the…

Image and Video Processing · Electrical Eng. & Systems 2023-07-31 Haoran Dou , Nishant Ravikumar , Alejandro F. Frangi

Synthesizability in small molecule generative design remains a bottleneck. Existing works that do consider synthesizability can output predicted synthesis routes for generated molecules. However, there has been minimal attention in…

Biomolecules · Quantitative Biology 2025-05-14 Jeff Guo , Víctor Sabanza-Gil , Zlatko Jončev , Jeremy S. Luterbacher , Philippe Schwaller

The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on…

Chemical Physics · Physics 2019-10-22 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Humans are able to identify and categorize novel compositions of known concepts. The task in Compositional Zero-Shot learning (CZSL) is to learn composition of primitive concepts, i.e. objects and states, in such a way that even their novel…

Computer Vision and Pattern Recognition · Computer Science 2022-04-27 Muhammad Umer Anwaar , Zhihui Pan , Martin Kleinsteuber

In the expansive realm of drug discovery, with approximately 15,000 known drugs and only around 4,200 approved, the combinatorial nature of the chemical space presents a formidable challenge. While Artificial Intelligence (AI) has emerged…

Machine Learning · Computer Science 2024-01-17 Abhijit Gupta

Generative models for graph data are an important research topic in machine learning. Graph data comprise two levels that are typically analyzed separately: node-level properties such as the existence of a link between a pair of nodes, and…

Machine Learning · Computer Science 2023-01-18 Kiarash Zahirnia , Oliver Schulte , Parmis Naddaf , Ke Li

Prerequisite chain learning helps people acquire new knowledge efficiently. While people may quickly determine learning paths over concepts in a domain, finding such paths in other domains can be challenging. We introduce Domain-Adversarial…

Machine Learning · Computer Science 2021-11-02 Irene Li , Vanessa Yan , Dragomir Radev
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