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In this paper we explore the power of tile self-assembly models that extend the well-studied abstract Tile Assembly Model (aTAM) by permitting tiles of shapes beyond unit squares. Our main result shows the surprising fact that any aTAM…

Data Structures and Algorithms · Computer Science 2012-12-20 Erik D. Demaine , Martin L. Demaine , Sándor P. Fekete , Matthew J. Patitz , Robert T. Schweller , Andrew Winslow , Damien Woods

Winfree's abstract Tile Assembly Model (aTAM) is a model of molecular self-assembly of DNA complexes known as tiles, which float freely in solution and attach one at a time to a growing "seed" assembly based on specific binding sites on…

Computational Complexity · Computer Science 2015-03-17 Ho-Lin Chen , David Doty , Shinnosuke Seki

Self-assembly is a process which is ubiquitous in natural, especially biological systems. It occurs when groups of relatively simple components spontaneously combine to form more complex structures. While such systems have inspired a large…

Computational Geometry · Computer Science 2018-07-19 Jerome Durand-Lose , Jacob Hendricks , Matthew J. Patitz , Ian Perkins , Michael Sharp

We prove that the abstract Tile Assembly Model (aTAM) of nanoscale self-assembly is intrinsically universal. This means that there is a single tile assembly system U that, with proper initialization, simulates any tile assembly system T.…

Data Structures and Algorithms · Computer Science 2012-04-10 David Doty , Jack H. Lutz , Matthew J. Patitz , Robert T. Schweller , Scott M. Summers , Damien Woods

Algorithmic self-assembly occurs when disorganized components autonomously combine to form structures and, by their design and the dynamics of the system, are forced to follow the execution of algorithms. Motivated by applications in…

Computational Geometry · Computer Science 2023-05-05 Daniel Hader , Matthew J. Patitz

As a mathematical model of self-assembling systems, Winfree's abstract Tile Assembly Model (aTAM) is a remarkable platform for studying the behaviors and powers of self-assembling systems. Capable of Turing universal computation, the aTAM…

Computational Geometry · Computer Science 2016-08-11 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers

Sequence-directed assembly processes - such as protein folding - allow the assembly of a large number of structures with high accuracy from only a small handful of fundamental building blocks. We aim to explore how efficiently sequence…

Biological Physics · Physics 2025-03-14 Jeremy Guntoro , Thomas Ouldridge

In this paper we define the Dupled abstract Tile Assembly Model (DaTAM), which is a slight extension to the abstract Tile Assembly Model (aTAM) that allows for not only the standard square tiles, but also "duple" tiles which are rectangles…

Emerging Technologies · Computer Science 2014-03-10 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers , Scott M. Summers

In this paper, we explore relationships between two models of systems which are governed by only the local interactions of large collections of simple components: cellular automata (CA) and the abstract Tile Assembly Model (aTAM). While…

Emerging Technologies · Computer Science 2013-09-09 Jacob Hendricks , Matthew J. Patitz

Tile assembly systems in the abstract Tile Assembly Model (aTAM) are computationally universal and capable of building complex shapes, but DNA-based implementations encounter formidable error rates that stifle this theoretical potential.…

Computational Geometry · Computer Science 2024-05-13 Phillip Drake , Daniel Hader , Matthew J. Patitz

We present a series of results related to mathematical models of self-assembling tiles and the impacts that three diverse properties have on their dynamics. We expand upon a series of prior results which showed that (1) the abstract Tile…

Computational Geometry · Computer Science 2019-10-10 Daniel Hader , Aaron Koch , Matthew J. Patitz , Michael Sharp

In this paper we present a model containing modifications to the Signal-passing Tile Assembly Model (STAM), a tile-based self-assembly model whose tiles are capable of activating and deactivating glues based on the binding of other glues.…

Emerging Technologies · Computer Science 2022-03-30 Andrew Alseth , Daniel Hader , Matthew J. Patitz

We define the Reflexive Tile Assembly Model (RTAM), which is obtained from the abstract Tile Assembly Model (aTAM) by allowing tiles to reflect across their horizontal and/or vertical axes. We show that the class of directed temperature-1…

Computational Geometry · Computer Science 2015-03-13 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers

We present a strict separation between the class of "mismatch free" self-assembly systems and general aTAM systems. Mismatch free systems are those systems in which concurrently grown parts must always agree with each other. Tile…

Computational Geometry · Computer Science 2015-02-20 Florent Becker , Pierre-Étienne Meunier

We prove a Pumping Lemma for the noncooperative abstract Tile Assembly Model, a model central to the theory of algorithmic self-assembly since the beginning of the field. This theory suggests, and our result proves, that small differences…

Computational Complexity · Computer Science 2020-02-11 Pierre-Étienne Meunier , Damien Regnault , Damien Woods

We investigate the role of nondeterminism in Winfree's abstract Tile Assembly Model (aTAM), which was conceived to model artificial molecular self-assembling systems constructed from DNA. Of particular practical importance is to find tile…

Computational Complexity · Computer Science 2010-11-29 Nathaniel Bryans , Ehsan Chiniforooshan , David Doty , Lila Kari , Shinnosuke Seki

In this work we propose a generalization of Winfree's abstract Tile Assembly Model (aTAM) in which tile types are assigned rigid shapes, or geometries, along each tile face. We examine the number of distinct tile types needed to assemble…

Computational Geometry · Computer Science 2015-03-19 Bin Fu , Matthew J. Patitz , Robert T. Schweller , Bobby Sheline

The abstract tile assembly model (aTam) is a model of DNA self-assembly. Most of the studies focus on cooperative aTAM where a form of synchronization between the tiles is possible. Simulating Turing machines is achievable in this context.…

Computational Complexity · Computer Science 2026-05-11 Sergiu Ivanov , Damien Regnault

Algorithmic self-assembly, a generalization of crystal growth processes, has been proposed as a mechanism for autonomous DNA computation and for bottom-up fabrication of complex nanostructures. A `program' for growing a desired structure…

Materials Science · Physics 2010-01-08 Rebecca Schulman , Erik Winfree

In this paper, we investigate shape-assembling power of a tile-based model of self-assembly called the Signal-Passing Tile Assembly Model (STAM). In this model, the glues that bind tiles together can be turned on and off by the binding…

Formal Languages and Automata Theory · Computer Science 2022-06-09 Andrew Alseth , Daniel Hader , Matthew J. Patitz
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