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Accurately predicting antibody-antigen binding residues, i.e., paratopes and epitopes, is crucial in antibody design. However, existing methods solely focus on uni-modal data (either sequence or structure), disregarding the complementary…

Biomolecules · Quantitative Biology 2024-06-03 Zhiwei Wang , Yongkang Wang , Wen Zhang

In multi-label learning, leveraging contrastive learning to learn better representations faces a key challenge: selecting positive and negative samples and effectively utilizing label information. Previous studies selected positive and…

Machine Learning · Computer Science 2025-02-03 Ning Chen , Shen-Huan Lyu , Tian-Shuang Wu , Yanyan Wang , Bin Tang

Contrastive Language-Image Pretraining (CLIP) models excel at understanding image-text relationships but struggle with adapting to new data without forgetting prior knowledge. To address this, models are typically fine-tuned using both new…

Machine Learning · Computer Science 2026-05-06 Ryan King , Gang Li , Bobak Mortazavi , Tianbao Yang

Multimodal retrieval, which seeks to retrieve relevant content across modalities such as text or image, supports applications from AI search to contents production. Despite the success of separate-encoder approaches like CLIP align…

Computation and Language · Computer Science 2025-10-20 Qiyu Wu , Shuyang Cui , Satoshi Hayakawa , Wei-Yao Wang , Hiromi Wakaki , Yuki Mitsufuji

Alignment of large language models (LLMs) with human values has recently garnered significant attention, with prominent examples including the canonical yet costly Reinforcement Learning from Human Feedback (RLHF) and the simple Direct…

Machine Learning · Computer Science 2025-10-14 Xufei Lv , Kehai Chen , Haoyuan Sun , Xuefeng Bai , Min Zhang , Houde Liu , Kehai Chen

Unlike traditional Multimodal Class-Incremental Learning (MCIL) methods that focus only on vision and text, this paper explores MCIL across vision, audio and text modalities, addressing challenges in integrating complementary information…

Machine Learning · Computer Science 2025-06-13 Yukun Chen , Zihuan Qiu , Fanman Meng , Hongliang Li , Linfeng Xu , Qingbo Wu

In the field of multi-task reinforcement learning, the modular principle, which involves specializing functionalities into different modules and combining them appropriately, has been widely adopted as a promising approach to prevent the…

Machine Learning · Computer Science 2023-11-03 Siming Lan , Rui Zhang , Qi Yi , Jiaming Guo , Shaohui Peng , Yunkai Gao , Fan Wu , Ruizhi Chen , Zidong Du , Xing Hu , Xishan Zhang , Ling Li , Yunji Chen

Multimodal deep learning utilizing imaging and diagnostic reports has made impressive progress in the field of medical imaging diagnostics, demonstrating a particularly strong capability for auxiliary diagnosis in cases where sufficient…

Computer Vision and Pattern Recognition · Computer Science 2024-08-21 Hao Yang , Hong-Yu Zhou , Cheng Li , Weijian Huang , Jiarun Liu , Yong Liang , Guangming Shi , Hairong Zheng , Qiegen Liu , Shanshan Wang

The task adaptation and alignment of Large Multimodal Models (LMMs) have been significantly advanced by instruction tuning and further strengthened by recent preference optimization. Yet, most LMMs still suffer from severe modality…

Machine Learning · Computer Science 2025-10-10 Chenxi Liu , Tianyi Xiong , Yanshuo Chen , Ruibo Chen , Yihan Wu , Junfeng Guo , Tianyi Zhou , Heng Huang

Lexical difficulty prediction is a fundamental problem in language learning and readability assessment, requiring models to estimate word difficulty across different first-language (L1) backgrounds. However, existing approaches rely on…

Computation and Language · Computer Science 2026-05-12 Wicaksono Leksono Muhamad , Joanito Agili Lopo , Tsamarah Rana Nugraha , Ahmad Cahyono Adi , Muhammad Oriza Nurfajri

In recent years, the use of edge information provided by knowledge graphs together with the advantages of higher-order connectivity in graph neural networks for recommendation systems has become an important research direction. However,…

Information Retrieval · Computer Science 2026-05-12 Zhifei Hu , Feng Xia

Modeling various aspects that make a music piece unique is a challenging task, requiring the combination of multiple sources of information. Deep learning is commonly used to obtain representations using various sources of information, such…

Sound · Computer Science 2021-04-05 Andres Ferraro , Xavier Favory , Konstantinos Drossos , Yuntae Kim , Dmitry Bogdanov

Current multimodal models leveraging contrastive learning often face limitations in developing fine-grained conceptual understanding. This is due to random negative samples during pretraining, causing almost exclusively very dissimilar…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Philipp J. Rösch , Norbert Oswald , Michaela Geierhos , Jindřich Libovický

Contrastive learning is an approach to representation learning that utilizes naturally occurring similar and dissimilar pairs of data points to find useful embeddings of data. In the context of document classification under topic modeling…

Machine Learning · Computer Science 2020-03-05 Christopher Tosh , Akshay Krishnamurthy , Daniel Hsu

Establishing voxelwise semantic correspondence across distinct imaging modalities is a foundational yet formidable computer vision task. Current multi-modality registration techniques maximize hand-crafted inter-domain similarity functions,…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Neel Dey , Jo Schlemper , Seyed Sadegh Mohseni Salehi , Bo Zhou , Guido Gerig , Michal Sofka

This paper targets the problem of multi-task dense prediction which aims to achieve simultaneous learning and inference on a bunch of multiple dense prediction tasks in a single framework. A core objective in design is how to effectively…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Siwei Yang , Hanrong Ye , Dan Xu

Multi-modal contrastive representation (MCR) of more than three modalities is critical in multi-modal learning. Although recent methods showcase impressive achievements, the high dependence on large-scale, high-quality paired data and the…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Zehan Wang , Ziang Zhang , Luping Liu , Yang Zhao , Haifeng Huang , Tao Jin , Zhou Zhao

Contrastive learning has shown remarkable results in recent self-supervised approaches for visual representation. By learning to contrast positive pairs' representation from the corresponding negatives pairs, one can train good visual…

Computer Vision and Pattern Recognition · Computer Science 2020-11-17 Sungnyun Kim , Gihun Lee , Sangmin Bae , Se-Young Yun

Reinforcement Learning from Human Feedback (RLHF) typically relies on static reward models to align Large Language Models with human preferences. However, human values are inherently diverse and heterogeneous, and a single reward model…

Machine Learning · Computer Science 2026-05-29 Zhenyu Sun , Zheng Xu , Ermin Wei

Contrastive learning is a powerful technique to learn representations that are semantically distinctive and geometrically invariant. While most of the earlier approaches have demonstrated its effectiveness on single-modality learning tasks…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Anurag Jain , Yashaswi Verma