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Neurosymbolic learning enables the integration of symbolic reasoning with deep learning but faces significant challenges in scaling to complex symbolic programs, large datasets, or both. We introduce DOLPHIN, a framework that tackles these…

Machine Learning · Computer Science 2026-01-01 Aaditya Naik , Jason Liu , Claire Wang , Amish Sethi , Saikat Dutta , Mayur Naik , Eric Wong

The evaluation of new microprocessor designs is constrained by slow, cycle-accurate simulators that rely on unrepresentative benchmark traces. This paper introduces a novel deep learning framework for high-fidelity, ``in-the-wild''…

Hardware Architecture · Computer Science 2025-10-01 Shayne Wadle , Yanxin Zhang , Vikas Singh , Karthikeyan Sankaralingam

DNA is a promising medium for digital information storage for its exceptional density and durability. While prior studies advanced coding theory, workflow design, and simulation tools, challenges such as synthesis costs, sequencing errors,…

Emerging Technologies · Computer Science 2025-10-06 Rakesh Thakur , Lavanya Singh , Yashika , Manomay Bundawala , Aruna Kumar

Quantum processors require rapid and high-fidelity simultaneous measurements of many qubits. While superconducting qubits are among the leading modalities toward a useful quantum processor, their readout remains a bottleneck. Traditional…

Quantum Physics · Physics 2026-04-08 Robert Kent , Benjamin Lienhard , Gregory Lafyatis , Daniel J. Gauthier

With ever increasing depth and width in deep neural networks to achieve state-of-the-art performance, deep learning computation has significantly grown, and dot-products remain dominant in overall computation time. Most prior works are…

Machine Learning · Computer Science 2023-02-10 Duy-Thanh Nguyen , Abhiroop Bhattacharjee , Abhishek Moitra , Priyadarshini Panda

Reading a qubit is a fundamental operation in quantum computing. It translates quantum information into classical information enabling subsequent classification to assign the qubit states `0' or `1'. Unfortunately, qubit readout is one of…

Recent developments in generative models have shown that deep learning combined with traditional digital signal processing (DSP) techniques could successfully generate convincing violin samples [1], that source-excitation combined with…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-07 Ollie McCarthy , Zohaib Ahmed

Advances in third-generation sequencing have enabled portable and real-time genomic sequencing, but real-time data processing remains a bottleneck, hampering on-site genomic analysis due to prohibitive time and energy costs. These…

Emerging Technologies · Computer Science 2025-04-23 Peiyi He , Shengbo Wang , Ruibin Mao , Sebastian Siegel , Giacomo Pedretti , Jim Ignowski , John Paul Strachan , Ruibang Luo , Can Li

The first important step in extracting DNA characters is using the output data of MinION devices in the form of electrical current signals. Various cutting-edge base callers use this data to detect the DNA characters based on the input. In…

Genomics · Quantitative Biology 2023-03-17 Ahmad Rezaei , Mahdi Taheri , Ali Mahani , Sebastian Magierowski

Raw nanopore signal analysis is a common approach in genomics to provide fast and resource-efficient analysis without translating the signals to bases (i.e., without basecalling). However, existing solutions cannot interpret raw signals…

Most GAN(Generative Adversarial Network)-based approaches towards high-fidelity waveform generation heavily rely on discriminators to improve their performance. However, GAN methods introduce much uncertainty into the generation process and…

Sound · Computer Science 2022-03-22 Shengyuan Xu , Wenxiao Zhao , Jing Guo

With conventional silicon-based computing approaching its physical and efficiency limits, biocomputing emerges as a promising alternative. This approach utilises biomaterials such as DNA and neurons as an interesting alternative to data…

Emerging Technologies · Computer Science 2024-08-15 Giulio Basso , Reinhold Scherer , Michael Taynnan Barros

Designing a qubit architecture is one of the most critical challenges in achieving scalable and fault-tolerant quantum computing as the performance of a quantum computer is heavily dependent on the coherence times, connectivity and low…

Basecalling, an essential step in many genome analysis studies, relies on large Deep Neural Networks (DNNs) to achieve high accuracy. Unfortunately, these DNNs are computationally slow and inefficient, leading to considerable delays and…

Hardware Architecture · Computer Science 2023-11-28 Taha Shahroodi , Gagandeep Singh , Mahdi Zahedi , Haiyu Mao , Joel Lindegger , Can Firtina , Stephan Wong , Onur Mutlu , Said Hamdioui

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose…

Image and Video Processing · Electrical Eng. & Systems 2020-06-11 Leonie Henschel , Sailesh Conjeti , Santiago Estrada , Kersten Diers , Bruce Fischl , Martin Reuter

Nanopore sequencing can read substantially longer sequences of nucleic acid molecules, called reads, than other sequencing methods, which has led to advances in genomic analysis such as the gapless human genome assembly. By analyzing the…

Genomics · Quantitative Biology 2026-05-21 Simon Ambrozak , Ulysse McConnell , Bhargav Srinivasan , Burak Ozkan , Ernest Zhang , Can Firtina

The task of understanding and interpreting the complex information encoded within genomic sequences remains a grand challenge in biological research and clinical applications. In this context, recent advancements in large language model…

Genomics · Quantitative Biology 2024-09-25 Qihang Zhao , Chi Zhang , Weixiong Zhang

Dynamic random walks are fundamental to various graph analysis applications, offering advantages by adapting to evolving graph properties. Their runtime-dependent transition probabilities break down the pre-computation strategy that…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-02 Seongyeon Park , Jaeyong Song , Changmin Shin , Sukjin Kim , Junguk Hong , Jinho Lee

Hand-sized Deoxyribonucleic acid (DNA) sequencing machines are of growing importance in several life sciences fields as their small footprints enable a broader range of use cases than their larger, stationary counterparts. However, as…

Hardware Architecture · Computer Science 2025-10-13 Abel Beyene , Zhongpan Wu , Yunus Dawji , Karim Hammad , Ebrahim Ghafar-Zadeh , Sebastian Magierowski

Learning under non-smooth objectives remains a fundamental challenge in machine learning, as abrupt changes in conditioning variables can induce highly non-smooth loss landscapes and destabilize optimization. This difficulty is particularly…

Optimization and Control · Mathematics 2026-03-16 Gyeongwan Gu , Jinwoo Hyun , Hyeontae Jo , Jae Kyoung Kim