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Physics-guided machine learning (PGML) has become a prevalent approach in studying scientific systems due to its ability to integrate scientific theories for enhancing machine learning (ML) models. However, most PGML approaches are tailored…

Machine Learning · Computer Science 2025-02-11 Runlong Yu , Chonghao Qiu , Robert Ladwig , Paul Hanson , Yiqun Xie , Xiaowei Jia

Numerical modeling of turbulent spray combustion provides a promising tool for advanced engine design. In spray flames, the droplet evaporation not only reduces the ambient gas temperature, but also influences flame structure by generating…

Fluid Dynamics · Physics 2025-07-03 Dong Wang , Min Zhang , Ruixin Yang , Zhi X. Chen

Singularly perturbed dynamical systems play a crucial role in climate dynamics and plasma physics. A powerful and well-known tool to address these systems is the Fenichel normal form, which significantly simplifies fast dynamics near slow…

Dynamical Systems · Mathematics 2025-05-14 Daniel A. Serino , Allen Alvarez Loya , Joshua W. Burby , Ioannis G. Kevrekidis , Qi Tang

Design of new drugs is a challenging process: a candidate molecule should satisfy multiple conditions to act properly and make the least side-effect -- perfect candidates selectively attach to and influence only targets, leaving off-targets…

Biomolecules · Quantitative Biology 2024-05-07 Andrij Rovenchak , Maksym Druchok

When dense granular gases are continuously excited under microgravity conditions, spatial inhomogeneities of the particle number density can emerge. A significant share of particles may collect in strongly overpopulated regions, called…

Soft Condensed Matter · Physics 2025-06-19 Sai Preetham Sata , Ralf Stannarius , Benjamin Noack , Dmitry Puzyrev

Accurate prediction of the physicochemical properties of molecular mixtures using graph neural networks remains a significant challenge, as it requires simultaneous embedding of intramolecular interactions while accounting for mixture…

Chemical Physics · Physics 2026-03-04 Jinming Fan , Chao Qian , Wilhelm T. S. Huck , William E. Robinson , Shaodong Zhou

Significant progress has been made on the model development for simulating turbulent reacting flows. As a consequence, we are currently in a position where key-physical aspects of fairly complex combustion processes are well understood at a…

Fluid Dynamics · Physics 2020-12-17 Matthias Ihme

Complex processes ranging from protein folding to nuclear fission often follow a low-dimension reaction path parameterized in terms of a few collective variables. In nuclear theory, variables related to the shape of the nuclear density in a…

Complex systems often show macroscopic coherent behavior due to the interactions of microscopic agents like molecules, cells, or individuals in a population with their environment. However, simulating such systems poses several…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-11 Asif Hamid , Danish Rafiq , Shahkar Ahmad Nahvi , Mohammad Abid Bazaz

The study of the rare transitions that take place between long lived metastable states is a major challenge in molecular dynamics simulations. Many of the methods suggested to address this problem rely on the identification of the slow…

Chemical Physics · Physics 2023-06-07 Dhiman Ray , Enrico Trizio , Michele Parrinello

Despite rapid improvements in the performance of central processing unit (CPU), the calculation cost of simulating chemically reacting flow using CFD remains infeasible in many cases. The application of the convolutional neural networks…

Machine Learning · Computer Science 2023-07-26 Joongoo Jeon , Juhyeong Lee , Sung Joong Kim

Generating molecular graphs with desired chemical properties driven by deep graph generative models provides a very promising way to accelerate drug discovery process. Such graph generative models usually consist of two steps: learning…

Machine Learning · Statistics 2020-06-19 Chengxi Zang , Fei Wang

To accurately study chemical reactions in the condensed phase or within enzymes, both a quantum-mechanical description and sufficient configurational sampling is required to reach converged estimates. Here, quantum mechanics/molecular…

Chemical Physics · Physics 2022-10-05 Albert Hofstetter , Lennard Böselt , Sereina Riniker

Fusion-graded plasmas are one of the physically complex systems, resulting in continuous establishment of plasma theories for unclarified physical phenomena in order to thoroughly control nuclear fusion reactors. Deep learning has drawn…

Plasma Physics · Physics 2023-01-30 Semin Joung

Turbulence in fluids, gases, and plasmas remains an open problem of both practical and fundamental importance. Its irreducible complexity usually cannot be tackled computationally in a brute-force style. Here, we combine Large Eddy…

Computational Physics · Physics 2023-09-29 Robin Greif , Frank Jenko , Nils Thuerey

Given their increasing participation in fast-changing markets, the integration of scheduling and control is an important consideration in chemical process operations. This generally involves computing optimal production schedules using…

Optimization and Control · Mathematics 2020-05-19 Calvin Tsay , Michael Baldea

We consider in this paper a challenging problem of simulating fluid flows, in complex multiscale media possessing multi-continuum background. As an effort to handle this obstacle, model reduction is employed. In \cite{rh2}, homogenization…

Numerical Analysis · Mathematics 2022-05-31 Jun Sur Richard Park , Siu Wun Cheung , Tina Mai , Viet Ha Hoang

Deep learning algorithms provide a new paradigm to study high-dimensional dynamical behaviors, such as those in fusion plasma systems. Development of novel model reduction methods, coupled with detection of abnormal modes with plasma…

Computational Physics · Physics 2024-04-29 Zhe Bai , Xishuo Wei , William Tang , Leonid Oliker , Zhihong Lin , Samuel Williams

Process optimization in chemical engineering may be hindered by the limited availability of reliable thermodynamic data for fluid mixtures. Remarkable progress is being made in predicting thermodynamic mixture properties by machine learning…

Computational Engineering, Finance, and Science · Computer Science 2025-10-14 Martin Bubel , Tobias Seidel , Michael Bortz

The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networks (GNNs) have been proposed to address this challenge.…

Machine Learning · Computer Science 2020-11-17 Shuo Zhang , Yang Liu , Lei Xie