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When does a large language model (LLM) know what it does not know? Uncertainty quantification (UQ) provides measures of uncertainty, such as an estimate of the confidence in an LLM's generated output, and is therefore increasingly…

Computation and Language · Computer Science 2025-10-17 Debarun Bhattacharjya , Balaji Ganesan , Junkyu Lee , Radu Marinescu , Katsiaryna Mirylenka , Michael Glass , Xiao Shou

Uncertainty quantification (UQ) is essential for deploying machine learning models in safety-critical physical systems, yet classical Bayesian approaches incur substantial computational overhead. We establish a formal connection between…

The role of uncertainty quantification (UQ) in deep learning has become crucial with growing use of predictive models in high-risk applications. Though a large class of methods exists for measuring deep uncertainties, in practice, the…

Machine Learning · Statistics 2019-11-01 Bindya Venkatesh , Jayaraman J. Thiagarajan

Treating uncertainties in models is essential in many fields of science and engineering. Uncertainty quantification (UQ) on complex and computationally costly numerical models necessitates a combination of efficient model solvers, advanced…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-28 Linus Seelinger , Anne Reinarz , Jean Benezech , Mikkel Bue Lykkegaard , Lorenzo Tamellini , Robert Scheichl

It is critical that machine learning (ML) model predictions be trustworthy for high-throughput catalyst discovery approaches. Uncertainty quantification (UQ) methods allow estimation of the trustworthiness of an ML model, but these methods…

Machine Learning · Computer Science 2023-02-07 Cameron Gruich , Varun Madhavan , Yixin Wang , Bryan Goldsmith

TodevelopanovelUncertaintyQuantification (UQ) framework to estimate the uncertainty of patient survival models in the absence of ground truth, we developed and evaluated our approach based on a dataset of 1383 patients treated with…

Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Raghav Mehta , Angelos Filos , Ujjwal Baid , Chiharu Sako , Richard McKinley , Michael Rebsamen , Katrin Datwyler , Raphael Meier , Piotr Radojewski , Gowtham Krishnan Murugesan , Sahil Nalawade , Chandan Ganesh , Ben Wagner , Fang F. Yu , Baowei Fei , Ananth J. Madhuranthakam , Joseph A. Maldjian , Laura Daza , Catalina Gomez , Pablo Arbelaez , Chengliang Dai , Shuo Wang , Hadrien Reynaud , Yuan-han Mo , Elsa Angelini , Yike Guo , Wenjia Bai , Subhashis Banerjee , Lin-min Pei , Murat AK , Sarahi Rosas-Gonzalez , Ilyess Zemmoura , Clovis Tauber , Minh H. Vu , Tufve Nyholm , Tommy Lofstedt , Laura Mora Ballestar , Veronica Vilaplana , Hugh McHugh , Gonzalo Maso Talou , Alan Wang , Jay Patel , Ken Chang , Katharina Hoebel , Mishka Gidwani , Nishanth Arun , Sharut Gupta , Mehak Aggarwal , Praveer Singh , Elizabeth R. Gerstner , Jayashree Kalpathy-Cramer , Nicolas Boutry , Alexis Huard , Lasitha Vidyaratne , Md Monibor Rahman , Khan M. Iftekharuddin , Joseph Chazalon , Elodie Puybareau , Guillaume Tochon , Jun Ma , Mariano Cabezas , Xavier Llado , Arnau Oliver , Liliana Valencia , Sergi Valverde , Mehdi Amian , Mohammadreza Soltaninejad , Andriy Myronenko , Ali Hatamizadeh , Xue Feng , Quan Dou , Nicholas Tustison , Craig Meyer , Nisarg A. Shah , Sanjay Talbar , Marc-Andre Weber , Abhishek Mahajan , Andras Jakab , Roland Wiest , Hassan M. Fathallah-Shaykh , Arash Nazeri , Mikhail Milchenko1 , Daniel Marcus , Aikaterini Kotrotsou , Rivka Colen , John Freymann , Justin Kirby , Christos Davatzikos , Bjoern Menze , Spyridon Bakas , Yarin Gal , Tal Arbel

Recent efforts in deploying Deep Neural Networks for object detection in real world applications, such as autonomous driving, assume that all relevant object classes have been observed during training. Quantifying the performance of these…

Computer Vision and Pattern Recognition · Computer Science 2021-11-29 Yimeng Li , Jana Kosecka

Development of an accurate, flexible, and numerically efficient uncertainty quantification (UQ) method is one of fundamental challenges in machine learning. Previously, a UQ method called DISCO Nets has been proposed (Bouchacourt et al.,…

Machine Learning · Computer Science 2023-07-06 Takuya Kanazawa , Chetan Gupta

Uncertainty Quantification (UQ) is a promising approach to improve model reliability, yet quantifying the uncertainty of Large Language Models (LLMs) is non-trivial. In this work, we establish a connection between the uncertainty of LLMs…

Computation and Language · Computer Science 2025-10-16 Mingda Li , Xinyu Li , Weinan Zhang , Longxuan Ma

In complex physical process characterization, such as the measurement of the regression rate for solid hybrid rocket fuels, where both the observation data and the model used have uncertainties originating from multiple sources, combining…

Machine Learning · Computer Science 2023-03-21 Georgios Georgalis , Kolos Retfalvi , Paul E. DesJardin , Abani Patra

Image-based environment perception is an important component especially for driver assistance systems or autonomous driving. In this scope, modern neuronal networks are used to identify multiple objects as well as the according position and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-07 Fabian Küppers

Uncertainty quantification (UQ) in machine learning is currently drawing increasing research interest, driven by the rapid deployment of deep neural networks across different fields, such as computer vision, natural language processing, and…

Machine Learning · Computer Science 2022-08-26 Zongren Zou , Xuhui Meng , Apostolos F Psaros , George Em Karniadakis

If Uncertainty Quantification (UQ) is crucial to achieve trustworthy Machine Learning (ML), most UQ methods suffer from disparate and inconsistent evaluation protocols. We claim this inconsistency results from the unclear requirements the…

Machine Learning · Computer Science 2022-07-28 Victor Bouvier , Simona Maggio , Alexandre Abraham , Léo Dreyfus-Schmidt

Depth measures are powerful tools for defining level sets in emerging, non--standard, and complex random objects such as high-dimensional multivariate data, functional data, and random graphs. Despite their favorable theoretical properties,…

In the critical task of making generative models trustworthy and robust, methods for Uncertainty Quantification (UQ) have begun to show encouraging potential. However, many of these methods rely on rigid heuristics that fail to generalize…

Machine Learning · Computer Science 2026-02-17 Souradeep Chattopadhyay , Brendan Kennedy , Sai Munikoti , Soumik Sarkar , Karl Pazdernik

Large language models(LLMs) are increasingly expanding their real-world applications across domains, e.g., question answering, autonomous driving, and automatic software development. Despite this achievement, LLMs, as data-driven systems,…

Artificial Intelligence · Computer Science 2025-12-09 Xianzong Wu , Xiaohong Li , Lili Quan , Qiang Hu

In this PhD thesis, we propose a novel framework for uncertainty quantification in machine learning, which is based on proper scores. Uncertainty quantification is an important cornerstone for trustworthy and reliable machine learning…

Machine Learning · Computer Science 2025-08-26 Sebastian G. Gruber

Quality control (QC) of MR images is essential to ensure that downstream analyses such as segmentation can be performed successfully. Currently, QC is predominantly performed visually and subjectively, at significant time and operator cost.…

Image and Video Processing · Electrical Eng. & Systems 2021-09-07 Richard Shaw , Carole H. Sudre , Sebastien Ourselin , M. Jorge Cardoso , Hugh G. Pemberton

Uncertainty Quantification (UQ) has gained traction in an attempt to improve the interpretability and robustness of machine learning predictions. Specifically (medical) biosignals such as electroencephalography (EEG), electrocardiography…

Signal Processing · Electrical Eng. & Systems 2025-06-06 Ivo Pascal de Jong , Andreea Ioana Sburlea , Matias Valdenegro-Toro
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