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Recently, the use of circle representation has emerged as a method to improve the identification of spherical objects (such as glomeruli, cells, and nuclei) in medical imaging studies. In traditional bounding box-based object detection,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Jialin Yue , Tianyuan Yao , Ruining Deng , Quan Liu , Juming Xiong , Junlin Guo , Haichun Yang , Yuankai Huo

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

Computer Vision and Pattern Recognition · Computer Science 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

Histopathological whole slide images (WSIs) classification has become a foundation task in medical microscopic imaging processing. Prevailing approaches involve learning WSIs as instance-bag representations, emphasizing significant…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Jiawen Li , Yuxuan Chen , Hongbo Chu , Qiehe Sun , Tian Guan , Anjia Han , Yonghong He

Patching gigapixel whole slide images (WSIs) is an important task in computational pathology. Some methods have been proposed to select a subset of patches as WSI representation for downstream tasks. While most of the computational…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Peyman Nejat , Areej Alsaafin , Ghazal Alabtah , Nneka Comfere , Aaron Mangold , Dennis Murphree , Patricija Zot , Saba Yasir , Joaquin J. Garcia , H. R. Tizhoosh

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

Evaluating the computational reproducibility of data analysis pipelines has become a critical issue. It is, however, a cumbersome process for analyses that involve data from large populations of subjects, due to their computational and…

Methodology · Statistics 2018-09-28 Soudabeh Barghi , Lalet Scaria , Ali Salari , Tristan Glatard

Multilayer network analysis has become a vital tool for understanding different relationships and their interactions in a complex system, where each layer in a multilayer network depicts the topological structure of a group of nodes…

Social and Information Networks · Computer Science 2017-09-18 Weiyi Liu , Pin-Yu Chen , Sailung Yeung , Toyotaro Suzumura , Lingli Chen

Convolutional Neural Network (CNN) models have become the state-of-the-art for most computer vision tasks with natural images. However, these are not best suited for multi-gigapixel resolution Whole Slide Images (WSIs) of histology slides…

Computer Vision and Pattern Recognition · Computer Science 2017-07-28 Abhinav Agarwalla , Muhammad Shaban , Nasir M. Rajpoot

Histopathology analysis is the gold standard for medical diagnosis. Accurate classification of whole slide images (WSIs) and region-of-interests (ROIs) localization can assist pathologists in diagnosis. The gigapixel resolution of WSI and…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Xitong Ling , Minxi Ouyang , Yizhi Wang , Xinrui Chen , Renao Yan , Hongbo Chu , Junru Cheng , Tian Guan , Sufang Tian , Xiaoping Liu , Yonghong He

Change Point Detection (CPD) aims to identify moments of abrupt distribution shifts in data streams. Real-world high-dimensional CPD remains challenging due to data pattern complexity and violation of common assumptions. Resorting to…

Machine Learning · Statistics 2025-10-03 Alexander Stepikin , Evgenia Romanenkova , Alexey Zaytsev

With appropriately chosen sampling probabilities, sampling-based random projection can be used to implement large-scale statistical methods, substantially reducing computational cost while maintaining low statistical error. However,…

Machine Learning · Statistics 2026-01-13 Yifan Chen , Yun Yang

Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient…

Image and Video Processing · Electrical Eng. & Systems 2025-06-09 Abhinav Sharma , Bojing Liu , Mattias Rantalainen

Image analysis tasks in computational pathology are commonly solved using convolutional neural networks (CNNs). The selection of a suitable CNN architecture and hyperparameters is usually done through exploratory iterative optimization,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-11 Lars Ole Schwen , Daniela Schacherer , Christian Geißler , André Homeyer

Encoding whole slide images (WSI) as graphs is well motivated since it makes it possible for the gigapixel resolution WSI to be represented in its entirety for the purpose of graph learning. To this end, WSIs can be broken into smaller…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Milan Aryal , Nasim Yahyasoltani

Using features extracted from networks pretrained on ImageNet is a common practice in applications of deep learning for digital pathology. However it presents the downside of missing domain specific image information. In digital pathology,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Jacob Gildenblat , Eldad Klaiman

In recent years, the use of deep learning (DL) methods, including convolutional neural networks (CNNs) and vision transformers (ViTs), has significantly advanced computational pathology, enhancing both diagnostic accuracy and efficiency.…

Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

Image and Video Processing · Electrical Eng. & Systems 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

Nowadays, many machine learning procedures are available on the shelve and may be used easily to calibrate predictive models on supervised data. However, when the input data consists of more than one unknown cluster, and when different…

Applications · Statistics 2019-11-18 Aurélie Fisher , Mathilde Mougeot , Sothea Has

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Information aggregation is a vital tool for human and machine decision making in the presence of uncertainty. Traditionally, approaches to aggregation broadly diverge into two categories, those which attribute a worth or weight to…

Artificial Intelligence · Computer Science 2024-05-06 Stephen B. Broomell , Christian Wagner