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Hyperparameter tuning is an active area of research in machine learning, where the aim is to identify the optimal hyperparameters that provide the best performance on the validation set. Hyperparameter tuning is often achieved using naive…

Machine Learning · Computer Science 2020-07-23 Ankur Sinha , Tanmay Khandait , Raja Mohanty

Facial manipulation by deep fake has caused major security risks and raised severe societal concerns. As a countermeasure, a number of deep fake detection methods have been proposed recently. Most of them model deep fake detection as a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-12 Aakash Varma Nadimpalli , Ajita Rattani

We present two novel hyperparameter optimization strategies for optimization of deep learning models with a modular architecture constructed of multiple subnetworks. As complex networks with multiple subnetworks become more frequently…

Machine Learning · Computer Science 2022-02-25 Alex H. Treacher , Albert Montillo

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

Machine Learning · Computer Science 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang

When approaching a clustering problem, choosing the right clustering algorithm and parameters is essential, as each clustering algorithm is proficient at finding clusters of a particular nature. Due to the unsupervised nature of clustering…

Machine Learning · Computer Science 2021-08-26 Elizabeth Ditton , Anne Swinbourne , Trina Myers , Mitchell Scovell

Single-cell RNA sequencing (scRNA-seq) technology provides high-throughput gene expression data to study the cellular heterogeneity and dynamics of complex organisms. Graph neural networks (GNNs) have been widely used for automatic cell…

Machine Learning · Computer Science 2023-12-19 Rui Yang , Wenrui Dai , Chenglin Li , Junni Zou , Dapeng Wu , Hongkai Xiong

Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present…

Quantitative Methods · Quantitative Biology 2025-06-13 Olga Ovcharenko , Florian Barkmann , Philip Toma , Imant Daunhawer , Julia Vogt , Sebastian Schelter , Valentina Boeva

Massive data analysis becomes increasingly prevalent, subsampling methods like BLB (Bag of Little Bootstraps) serves as powerful tools for assessing the quality of estimators for massive data. However, the performance of the subsampling…

Methodology · Statistics 2022-01-14 Yingying Ma , Hansheng Wang

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Proper hyperparameter tuning is essential for achieving optimal performance of modern machine learning (ML) methods in predictive tasks. While there is an extensive literature on tuning ML learners for prediction, there is only little…

Econometrics · Economics 2024-02-08 Philipp Bach , Oliver Schacht , Victor Chernozhukov , Sven Klaassen , Martin Spindler

Spatially resolved transcriptomics (SRT) has evolved rapidly through various technologies, enabling scientists to investigate both morphological contexts and gene expression profiling at single-cell resolution in parallel. SRT data are…

In this paper, a hyperparameter tuning based Bayesian optimization of digital twins is carried out to diagnose various faults in grid connected inverters. As fault detection and diagnosis require very high precision, we channelize our…

Systems and Control · Electrical Eng. & Systems 2022-12-08 Pavol Mulinka , Subham Sahoo , Charalampos Kalalas , Pedro H. J. Nardelli

Hyperparameter optimization can be formulated as a bilevel optimization problem, where the optimal parameters on the training set depend on the hyperparameters. We aim to adapt regularization hyperparameters for neural networks by fitting…

Machine Learning · Computer Science 2019-03-08 Matthew MacKay , Paul Vicol , Jon Lorraine , David Duvenaud , Roger Grosse

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

Quantitative Methods · Quantitative Biology 2023-01-11 Nana Wei , Yating Nie , Lin Liu , Xiaoqi Zheng , Hua-Jun Wu4

Recent progress on salient object detection mainly aims at exploiting how to effectively integrate multi-scale convolutional features in convolutional neural networks (CNNs). Many popular methods impose deep supervision to perform…

Computer Vision and Pattern Recognition · Computer Science 2021-01-21 Yun Liu , Ming-Ming Cheng , Xinyu Zhang , Guang-Yu Nie , Meng Wang

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells, which has given us insights into cell-cell communication, cell differentiation, and differential gene expression. However, analyzing scRNA-seq data is a…

Quantitative Methods · Quantitative Biology 2023-10-24 Sean Cottrell , Yuta Hozumi , Guo-Wei Wei

Deep learning techniques are often criticized to heavily depend on a large quantity of labeled data. This problem is even more challenging in medical image analysis where the annotator expertise is often scarce. We propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2019-07-30 Florian Dubost , Gerda Bortsova , Hieab Adams , M. Arfan Ikram , Wiro Niessen , Meike Vernooij , Marleen de Bruijne

This paper considers the hyperparameter optimization problem of mathematical techniques that arise in the numerical solution of differential and integral equations. The well-known approaches grid and random search, in a parallel algorithm…

Numerical Analysis · Mathematics 2023-04-28 Alireza Afzal Aghaei , Kourosh Parand

The single image super-resolution task is one of the most examined inverse problems in the past decade. In the recent years, Deep Neural Networks (DNNs) have shown superior performance over alternative methods when the acquisition process…

Computer Vision and Pattern Recognition · Computer Science 2020-05-27 Shady Abu Hussein , Tom Tirer , Raja Giryes