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Cell differentiation in multicellular organisms is a complex process whose mechanism can be understood by a reductionist approach, in which the individual processes that control the generation of different cell types are identified.…

For the first time the phenomenon of cellular structure coarsening are consistently analysed from the positions of kinetic, hydrodynamic and stochastodynamic theories of nonequilibrium statistical systems. Thereby micro-, meso- and…

Condensed Matter · Physics 2015-06-25 S. B. Goryachev

Complex network dynamics have been analyzed with models of systems of coupled switches or systems of coupled oscillators. However, many complex systems are composed of components with diverse dynamics whose interactions drive the system's…

Quantitative Methods · Quantitative Biology 2012-01-09 Matthew R. Francis , Elana J. Fertig

In neural circuits, statistical connectivity rules strongly depend on neuronal type. Here we study dynamics of neural networks with cell-type specific connectivity by extending the dynamic mean field method, and find that these networks…

Neurons and Cognition · Quantitative Biology 2015-02-24 Johnatan Aljadeff , Merav Stern , Tatyana O. Sharpee

All systolic or distributed neuromorphic architectures require power-efficient processing nodes. In this paper, a unifying tutorial is presented which implements multiple neuromorphic processing elements using a systematic analog approach…

Neural and Evolutionary Computing · Computer Science 2021-08-21 Hamid Soleimani , Emmanuel. M. Drakakis

Gamma-band rhythmic inhibition is a ubiquitous phenomenon in neural circuits yet its computational role still remains elusive. We show that a model of Gamma-band rhythmic inhibition allows networks of coupled cortical circuit motifs to…

Neurons and Cognition · Quantitative Biology 2017-11-08 Hesham Mostafa , Lorenz K. Muller , Giacomo Indiveri

A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of…

Adaptation and Self-Organizing Systems · Physics 2014-01-16 H. Sedaghat , M. A. Wood , J. W. Cain , C-K. Cheng , C. M. Baumgarten , D. M. Chan

Tissue dynamics play a crucial role in biological processes ranging from inflammation to morphogenesis. However, these noisy multicellular dynamics are notoriously hard to predict. Here, we introduce a biomimetic machine learning framework…

Soft Condensed Matter · Physics 2025-11-06 Ming Han , John Devany , Michel Fruchart , Margaret L. Gardel , Vincenzo Vitelli

Modeling dynamical systems and unraveling their underlying causal relationships is central to many domains in the natural sciences. Various physical systems, such as those arising in cell biology, are inherently high-dimensional and…

In realistic neural circuits, both neurons and synapses are coupled in dynamics with separate time scales. The circuit functions are intimately related to these coupled dynamics. However, it remains challenging to understand the intrinsic…

Neurons and Cognition · Quantitative Biology 2025-11-11 Wenkang Du , Haiping Huang

Neural computation is associated with the emergence, reconfiguration and dissolution of cell assemblies in the context of varying oscillatory states. Here, we describe the complex spatio-temporal dynamics of cell assemblies through temporal…

Neurons and Cognition · Quantitative Biology 2020-01-20 Nicola Pedreschi , Christophe Bernard , Wesley Clawson , Pascale Quilichini , Alain Barrat , Demian Battaglia

Neuromorphic computing systems comprise networks of neurons that use asynchronous events for both computation and communication. This type of representation offers several advantages in terms of bandwidth and power consumption in…

Hardware Architecture · Computer Science 2017-11-07 Saber Moradi , Ning Qiao , Fabio Stefanini , Giacomo Indiveri

The onset of regular bursts in a group of irregularly bursting neurons with different individual properties is one of the most interesting dynamical properties found in neurobiological systems. In this paper we show how synchronization…

Chaotic Dynamics · Physics 2009-10-31 Nikolai F. Rulkov

Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its…

Neurons and Cognition · Quantitative Biology 2025-01-09 David G. Clark , Manuel Beiran

How do landscape fragmentation affects ecosystems diversity and stability is an important and complex question in ecology with no simple answer, as spatially separated habitats where species live are highly dynamic rather than just static.…

Chaotic Dynamics · Physics 2016-08-17 Ramesh Arumugam , Partha Sharathi Dutta , Tanmoy Banerjee

In this paper we study a simple cascading process in a structured heterogeneous population, namely, a network composed of two loosely coupled communities. We demonstrate that under certain conditions the cascading dynamics in such a network…

Statistical Mechanics · Physics 2008-03-14 Aram Galstyan , Paul Cohen

It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort…

Molecular Networks · Quantitative Biology 2009-11-10 Kevin S. Brown , Colin C. Hill , Guillermo A. Calero , Kelvin H. Lee , James P. Sethna , Richard A. Cerione

To understand the behavior of a neural circuit it is a presupposition that we have a model of the dynamical system describing this circuit. This model is determined by several parameters, including not only the synaptic weights, but also…

Neural and Evolutionary Computing · Computer Science 2016-08-23 J. Fischer , P. Manoonpong , S. Lackner

Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…

Neurons and Cognition · Quantitative Biology 2022-10-25 Veronika Koren , Stefano Panzeri

Recent studies have shown how spiking networks can learn complex functionality through error-correcting plasticity, but the resulting structures and dynamics remain poorly studied. To elucidate how these models may link to observed dynamics…

Neurons and Cognition · Quantitative Biology 2025-08-19 Jonas Oberste-Frielinghaus , Anno C. Kurth , Julian Göltz , Laura Kriener , Junji Ito , Mihai A. Petrovici , Sonja Grün