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While molecular pre-training has shown great potential in enhancing drug discovery, the lack of a solid physical interpretation in current methods raises concerns about whether the learned representation truly captures the underlying…

Biomolecules · Quantitative Biology 2023-11-07 Yuyan Ni , Shikun Feng , Wei-Ying Ma , Zhi-Ming Ma , Yanyan Lan

Click-evoked otoacoustic emissions (CEOAEs) are clinically used as an objective way to infer whether cochlear functions are normal. However, because the sound pressure level of CEOAEs is typically much lower than the background noise, it…

Signal Processing · Electrical Eng. & Systems 2021-04-28 Tzu-Chi Liu , Yi-Wen Liu , Hau-Tieng Wu

In many scientific applications, measured time series are corrupted by noise or distortions. Traditional denoising techniques often fail to recover the signal of interest, particularly when the signal-to-noise ratio is low or when certain…

Machine Learning · Computer Science 2022-11-02 Natalie Klein , Amber J. Day , Harris Mason , Michael W. Malone , Sinead A. Williamson

The hearing loss of almost half a billion people is commonly treated with hearing aids. However, current hearing aids often do not work well in real-world noisy environments. We present a deep learning based denoising system that runs in…

Recently developed deep-learning-based denoisers often outperform state-of-the-art conventional denoisers such as the BM3D. They are typically trained to minimize the mean squared error (MSE) between the output image of a deep neural…

Computer Vision and Pattern Recognition · Computer Science 2021-04-23 Shakarim Soltanayev , Se Young Chun

Traditional supervised denoisers are trained using pairs of noisy input and clean target images. They learn to predict a central tendency of the posterior distribution over possible clean images. When, e.g., trained with the popular…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Benjamin Salmon , Alexander Krull

Deep learning-based models have greatly advanced the performance of speech enhancement (SE) systems. However, two problems remain unsolved, which are closely related to model generalizability to noisy conditions: (1) mismatched noisy…

Audio and Speech Processing · Electrical Eng. & Systems 2020-12-29 Cheng Yu , Ryandhimas E. Zezario , Syu-Siang Wang , Jonathan Sherman , Yi-Yen Hsieh , Xugang Lu , Hsin-Min Wang , Yu Tsao

Accurate analysis of microscopy images is hindered by the presence of noise. This noise is usually signal-dependent and often additionally correlated along rows or columns of pixels. Current self- and unsupervised denoisers can address…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Benjamin Salmon , Alexander Krull

Unsupervised denoising is a crucial challenge in real-world imaging applications. Unsupervised deep-learning methods have demonstrated impressive performance on benchmarks based on synthetic noise. However, no metrics are available to…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Adria Marcos-Morales , Matan Leibovich , Sreyas Mohan , Joshua Lawrence Vincent , Piyush Haluai , Mai Tan , Peter Crozier , Carlos Fernandez-Granda

Existing deep learning-based speech denoising approaches require clean speech signals to be available for training. This paper presents a deep learning-based approach to improve speech denoising in real-world audio environments by not…

Audio and Speech Processing · Electrical Eng. & Systems 2020-02-25 Nasim Alamdari , Arian Azarang , Nasser Kehtarnavaz

Purpose: To develop a deep learning approach to de-noise optical coherence tomography (OCT) B-scans of the optic nerve head (ONH). Methods: Volume scans consisting of 97 horizontal B-scans were acquired through the center of the ONH using a…

Compared with traditional seismic noise attenuation algorithms that depend on signal models and their corresponding prior assumptions, removing noise with a deep neural network is trained based on a large training set, where the inputs are…

Geophysics · Physics 2019-07-23 Siwei Yu , Jianwei Ma , Wenlong Wang

Noise reduction techniques based on deep learning have demonstrated impressive performance in enhancing the overall quality of recorded speech. While these approaches are highly performant, their application in audio engineering can be…

Sound · Computer Science 2023-10-18 Christian J. Steinmetz , Thomas Walther , Joshua D. Reiss

De-noising plays a crucial role in the post-processing of spectra. Machine learning-based methods show good performance in extracting intrinsic information from noisy data, but often require a high-quality training set that is typically…

Materials Science · Physics 2023-05-16 Dongchen Huang , Junde Liu , Tian Qian , Yi-feng Yang

Optical spectra contain a wealth of information about the physical properties and formation histories of galaxies. Often though, spectra are too noisy for this information to be accurately retrieved. In this study, we explore how machine…

Astrophysics of Galaxies · Physics 2023-10-17 M. Scourfield , A. Saintonge , D. de Mijolla , S. Viti

This letter introduces a new denoiser that modifies the structure of denoising autoencoder (DAE), namely noise learning based DAE (nlDAE). The proposed nlDAE learns the noise of the input data. Then, the denoising is performed by…

Machine Learning · Computer Science 2022-01-24 Woong-Hee Lee , Mustafa Ozger , Ursula Challita , Ki Won Sung

Denoising autoencoders (DAE) are trained to reconstruct their clean inputs with noise injected at the input level, while variational autoencoders (VAE) are trained with noise injected in their stochastic hidden layer, with a regularizer…

Machine Learning · Computer Science 2016-01-05 Daniel Jiwoong Im , Sungjin Ahn , Roland Memisevic , Yoshua Bengio

Objective. Wearable devices with embedded photoplethysmography (PPG) enable continuous non-invasive monitoring of cardiac activity, offering a promising strategy to reduce the global burden of cardiovascular diseases. However, monitoring…

Signal Processing · Electrical Eng. & Systems 2025-08-15 Giulio Basso , Xi Long , Reinder Haakma , Rik Vullings

Seismic exploration is currently the most mature approach for studying subsurface structures, yet the presence of noise greatly restricts its imaging accuracy. Previous methods still face significant challenges: traditional computational…

Geophysics · Physics 2025-11-25 Junheng Peng , Yong Li , Yingtian LIu , Mingwei Wang

This work proposes a learning-based statistical refinement method for improving the denoising results of a given denoiser without knowing the precise noise distribution or accessing clean images or calibration data. While there are many…

Machine Learning · Computer Science 2026-05-07 Rihuan Ke