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Particles suspended in a fluid flow through a curved duct can focus to specific locations within the duct cross-section. This particle focusing is a result of a balance between two dominant forces acting on the particle: (i) the inertial…

Dynamical Systems · Mathematics 2024-01-17 Rahil N. Valani , Brendan Harding , Yvonne M. Stokes

Particles suspended in fluid flow through a curved duct focus to stable equilibrium positions in the duct cross-section due to the balance of two dominant forces: (i) inertial lift force - arising from the inertia of the fluid, and (ii)…

Fluid Dynamics · Physics 2021-12-10 Rahil N. Valani , Brendan Harding , Yvonne M. Stokes

Small finite-size particles suspended in fluid flow through an enclosed curved duct can focus to points or periodic orbits in the two-dimensional duct cross-section. This particle focusing is due to a balance between inertial lift forces…

Fluid Dynamics · Physics 2024-11-20 Rahil N. Valani , Brendan Harding , Yvonne M. Stokes

Inertial focusing in curved microfluidic ducts exploits the interaction of drag force from the Dean flow with the inertial lift force to separate particles or cells laterally across the cross-section width according to their size.…

Fluid Dynamics · Physics 2023-10-31 Brendan Harding , Yvonne M. Stokes , Rahil N. Valani

Microchannels are well-known in microfluidic applications for the control and separation of microdroplets and cells. Often the objects in the flow experience inertial effects, resulting in dynamics that is a departure from the underlying…

Fluid Dynamics · Physics 2022-01-19 Kyung Ha , Brendan Harding , Andrea L. Bertozzi , Yvonne M. Stokes

In inertial microfluidics lift forces cause a particle to migrate across streamlines to specific positions in the cross section of a microchannel. We control the rotational motion of a particle and demonstrate that this allows to manipulate…

Fluid Dynamics · Physics 2014-02-11 Christopher Prohm , Nikolas Zöller , Holger Stark

A flowing pair of particles in inertial microfluidics gives important insights into understanding and controlling the collective dynamics of particles like cells or droplets in microfluidic devices. They are applied in medical cell analysis…

Fluid Dynamics · Physics 2018-05-25 Christian Schaaf , Felix Rühle , Holger Stark

We present a computational investigation of the mechanism governing size-based particle separation in microfluidic pinched flow fractionation. We study the behavior of particles moving through a pinching gap (i.e., a constriction in the…

Fluid Dynamics · Physics 2016-05-04 Sumedh R. Risbud , German Drazer

The identification of cells and particles based on their transport properties in microfluidic devices is crucial for numerous applications in biology and medicine. Neutrally buoyant particles transported in microfluidic channels, migrate…

We develop a model of the forces on a spherical particle suspended in flow through a curved duct under the assumption that the particle Reynolds number is small. This extends an asymptotic model of inertial lift force previously developed…

Fluid Dynamics · Physics 2025-12-19 B. Harding , Y. M. Stokes , A. L. Bertozzi

The recent advent of advanced microfabrication capabilities of microfluidic devices has driven attention towards the behavior of particles in inertial flows within microchannels for applications related to the separation and concentration…

Fluid Dynamics · Physics 2018-12-03 Mike Garcia , Sumita Pennathur

We examine the effect of Dean number on the inertial focusing of spherical particles suspended in flow through curved microfluidic ducts. Previous modelling of particle migration in curved ducts assumed the flow rate was small enough that a…

Fluid Dynamics · Physics 2023-03-22 Brendan Harding , Yvonne M. Stokes

The manipulation and control of microparticles through non-intrusive methods is pivotal in biomedical applications such as cell sorting and cell focusing. Although several experimental and numerical studies have been dedicated to single…

Fluid Dynamics · Physics 2023-12-20 Giancarlo Esposito , Gaetano D'Avino , Massimiliano Maria Villone

We present a numerical study of the effect that fluid and particle inertia have on the motion of suspended spherical particles through a geometric constriction to understand analogous microfluidic settings, such as pinched flow…

Fluid Dynamics · Physics 2013-06-20 Sumedh R. Risbud , Mingxiang Luo , Joelle Frechette , German Drazer

The problem of the splitting of a suspension in bifurcating channels dividing into two branches of non equal flow rates is addressed. As observed for long, in particular in blood flow studies, the volume fraction of particles generally…

Fluid Dynamics · Physics 2012-04-27 Vincent Doyeux , Thomas Podgorski , Sarah Peponas , Mourad Ismail , Gwennou Coupier

Pinched flow fractionation is shown to be an efficient and selective way to quickly separate particles by size in a very polydisperse semi-concentrated suspension. In an effort to optimize the method, we discuss the quantitative influence…

Fluid Dynamics · Physics 2012-04-17 Aparna Srivastav , Thomas Podgorski , Gwennou Coupier

To understand the behavior of composite fluid particles such as nucleated cells and double-emulsions in flow, we study a finite-size particle encapsulated in a deforming droplet under shear flow as a model system. In addition to its…

Fluid Dynamics · Physics 2019-06-06 Lailai Zhu , François Gallaire

In microfluidic devices, inertia drives particles to focus on a finite number of inertial focusing streamlines. Particles on the same streamline interact to form one-dimensional microfluidic crystals (or "particle trains"). Here we develop…

Fluid Dynamics · Physics 2018-09-12 Kaitlyn Hood , Marcus Roper

Within microcentrifuge devices, a microfluidic vortex separates larger particles from a heterogeneous suspension using inertial migration, a phenomenon that causes particles to migrate across streamlines. The ability to selectively capture…

Fluid Dynamics · Physics 2023-03-14 Samuel Christensen , Marcus Roper

Inertial microfluidic is able to focus and separate particles in microchannels based on the characteristic geometry and intrinsic hydrodynamic effect. Yet, the vertical position of suspended particles in the microchannel cannot be…

Fluid Dynamics · Physics 2022-07-22 Chengliang Xuan , Weiyin Liang , Bing He , Binghai Wen
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