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We study charge transport in an ionic solution in a confined nanoscale geometry in the presence of an externally applied electric field and immobile background charges. For a range of parameters, the ion current shows non-monotonic behavior…

Statistical Mechanics · Physics 2015-05-13 Punyabrata Pradhan , Yariv Kafri , Dov Levine

The MARTINI coarse-grained (CG) force field is used to test the ability of CG models to simulate ionic transport through protein nanopores. The ionic conductivity of CG ions in solution was computed and compared with experimental results.…

Biological Physics · Physics 2025-10-16 Basdevant Nathalie , Dessaux Delphine , Ramirez Rosa

The characterization of individual nanoparticles in a liquid constitutes a critical challenge for environmental, material, and biological sciences. To detect nanoparticles, electronic approaches are especially desirable owing to their…

Nitrogen-vacancy (NV) based quantum sensors hold great potential for real-time single-cell sensing with far-reaching applications in fundamental biology and medical diagnostics. Although highly sensitive, the mapping of quantum measurements…

Tunable nanopores in elastomeric membranes have been used to study the dependence of ionic current blockade rate on the concentration and electrophoretic mobility of particles in aqueous suspensions. A range of nanoparticle sizes, materials…

Soft Condensed Matter · Physics 2010-05-25 G R Willmott , R Vogel , S S C Yu , L G Groenewegen , G S Roberts , D Kozak , W Anderson , M Trau

During the dielectric breakdown process of thin solid-state nanopores, the application of high voltages may cause the formation of multi-nanopores on one chip, which number and sizes are important for their applications. Here, simulations…

Chemical Physics · Physics 2024-10-30 Yinghua Qiu , Long Ma , Zhe Liu , Hongwen Zhang , Bowen Ai , Xinman Tu

Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers from a lack of sensitivity since the ion counts for a…

Quantitative Methods · Quantitative Biology 2017-07-05 Mikhail Kolmogorov , Eamonn Kennedy , Zhuxin Dong , Gregory Timp , Pavel Pevzner

Electroosmosis is a fascinating effect where liquid motion is induced by an applied electric field. Counter ions accumulate in the vicinity of charged surfaces, triggering a coupling between liquid mass transport and external electric…

Several sensing concepts using nanostructures prepared by focused electron beam induced deposition have been developed over the last years. Following work on highly miniaturized Hall sensors for magnetic sensing with soft magnetic Co,…

Mesoscale and Nanoscale Physics · Physics 2015-06-19 Michael Huth , Florian Kolb , Harald Plank

Understanding the dynamics of electrical signals within neuronal assemblies is crucial to unraveling complex brain function. Despite recent advances in employing optically active nanostructures in transmembrane potential sensing, there…

Fundamental mechanisms of energy storage, corrosion, sensing, and multiple biological functionalities are directly coupled to electrical processes and ionic dynamics at solid-liquid interfaces. In many cases, these processes are spatially…

Materials Science · Physics 2017-01-25 Liam Collins , Jason Kilpatrick , Sergei V. Kalinin , Brian J. Rodriguez

Transport measurements are powerful tools to probe electronic properties of solid-state materials. To access properties of local electronic states in nanostructures, such as local density of states, electronic distribution and so on,…

In solid-state nanopores, achieving reliable control over pore aperture opening and closing (gating) remains a major challenge. Gating can be driven by the applied voltage involving electrically tunable chemical reactions, achieved by…

A technology for recording electrical activity of large neuron populations at arbitrary depth in brain tissues with less than cell spatial and millisecond temporal resolutions was the most craving dream of neuroscientists and a long pursued…

Biological Physics · Physics 2013-09-02 Roman V. Beletskiy

Short nanopores find extensive applications capitalizing on their high throughput and detection resolution. Ionic behaviors through long nanopores are mainly determined by charged inner-pore walls. When pore lengths decrease to sub-200 nm,…

Chemical Physics · Physics 2024-02-19 Long Ma , Zhe Liu , Bowen Ai , Jia Man , Jianyong Li , Kechen Wu , Yinghua Qiu

In recent years, extracellular vesicles such have become promising carriers as the next-generation drug delivery platforms. Effective loading of exogenous cargos without compromising the extracellular vesicle membrane is a major challenge.…

Biomolecules · Quantitative Biology 2023-04-14 Khayrul Islam , Meghdad Razizadeh , Yaling Liu

Nanoporous membranes, leveraging their high-throughput characteristics, have been widely applied in fields such as molecular separation and energy conversion. Due to interpore interactions, besides the applied voltage and solution…

Soft Condensed Matter · Physics 2025-10-21 Hongwen Zhang , Bowen Ai , Zekun Gong , Tianyi Sui , Zuzanna S. Siwy , Yinghua Qiu

Solid-state nanopores are emerging platforms for single-molecule protein sequencing due to their tolerance to hash physiology environment and compatibility with different electrical and optical detection methods. However, they suffer from…

Applied Physics · Physics 2024-01-05 Yingqi Zhao , Aliaksandr Hubarevich , Jian-An Huang , Francesco De Angelis

We present a method of sensing AC magnetic fields. The method is based on the construction of a robust qubit by the application of continuous driving fields. Specifically, magnetic noise and power fluctuations of the driving fields do not…

Quantum Physics · Physics 2017-07-13 N. Aharon , M. Drewsen , A. Retzker

A microscopic physical analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The analysis relies on a combined experimental-theoretical…

Mesoscale and Nanoscale Physics · Physics 2020-04-23 Mingye Xiong , Michael Graf , Nagendra Athreya , Aleksandra Radenovic , Jean-Pierre Leburton