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The field of brain-computer interfaces is poised to advance from the traditional goal of controlling prosthetic devices using brain signals to combining neural decoding and encoding within a single neuroprosthetic device. Such a device acts…

Artificial Intelligence · Computer Science 2018-12-31 Rajesh P. N. Rao

Brain-computer interfaces (BCIs) use decoding algorithms to control prosthetic devices based on brain signals for restoration of lost function. Computer-brain interfaces (CBIs), on the other hand, use encoding algorithms to transform…

Artificial Intelligence · Computer Science 2020-12-08 Rajesh P. N. Rao

Mental disorders may exhibit pathological brain rhythms and neurostimulation promises to alleviate of patients' symptoms by modifying these rhythms. Today, most neurostimulation schemes are open-loop, i.e. administer experimental…

Neurons and Cognition · Quantitative Biology 2023-03-21 Thomas Wahl , Michel Duprez , Axel Hutt

Adaptive brain stimulation can treat neurological conditions such as Parkinson's disease and post-stroke motor deficits by influencing abnormal neural activity. Because of patient heterogeneity, each patient requires a unique stimulation…

Machine Learning · Computer Science 2024-11-01 Michelle Pan , Mariah Schrum , Vivek Myers , Erdem Bıyık , Anca Dragan

Neurostimulation technologies have seen a recent surge in interest from the neuroscience and controls communities alike due to their proven potential to treat conditions such as Parkinson's Disease, and depression. The provided stimulation…

Systems and Control · Electrical Eng. & Systems 2023-01-03 Gagan Acharya , Sebastian F. Ruf , Erfan Nozari

The application of closed-loop approaches in systems neuroscience and therapeutic stimulation holds great promise for revolutionizing our understanding of the brain and for developing novel neuromodulation therapies to restore lost…

Signal Processing · Electrical Eng. & Systems 2021-10-12 Bingzhao Zhu , Uisub Shin , Mahsa Shoaran

Computational neuroscience relies on large-scale dynamical-systems models of neurons, with a vast amount of offline, pre-simulation, tuned parameters, with models often tied to their brain simulators. These fixed parameters lead to stiff…

Neurons and Cognition · Quantitative Biology 2025-12-25 Lennart P. L. Landsmeer , Mario Negrello , Said Hamdioui , Christos Strydis

Mental disorders (MD) are among the top most demanding challenges in world-wide health. According to the World Health Organization, the burden of MDs continues to grow with significant impact on health and major social and human rights. A…

Neurons and Cognition · Quantitative Biology 2023-03-21 Thomas Wahl , Joséphine Riedinger , Michel Duprez , Axel Hutt

A significant and rising proportion of the global population suffer from non-communicable diseases, such as neurological disorders. Neurorehabilitation aims to restore function and independence of neurological patients through providing…

Objective: The aim of this study is to propose an adaptive scheme embedded into an open-source environment for the estimation of the neural activation extent during deep brain stimulation and to investigate the feasibility of approximating…

Neurons and Cognition · Quantitative Biology 2017-08-09 Christian Schmidt , Ursula van Rienen

We propose a neural information processing system which is obtained by re-purposing the function of a biological neural circuit model, to govern simulated and real-world control tasks. Inspired by the structure of the nervous system of the…

Machine Learning · Computer Science 2019-11-21 Ramin Hasani , Mathias Lechner , Alexander Amini , Daniela Rus , Radu Grosu

For robot manipulation, both the controller and end-effector design are crucial. Soft grippers are generalizable by deforming to different geometries, but designing such a gripper and finding its grasp pose remains challenging. In this…

Robotics · Computer Science 2025-09-03 Sha Yi , Xueqian Bai , Adabhav Singh , Jianglong Ye , Michael T Tolley , Xiaolong Wang

We present a neural network approach for closed-loop deep brain stimulation (DBS). We cast the problem of finding an optimal neurostimulation strategy as a control problem. In this setting, control policies aim to optimize therapeutic…

Optimization and Control · Mathematics 2023-11-14 Malvern Madondo , Deepanshu Verma , Lars Ruthotto , Nicholas Au Yong

Objective: Closed-loop deep brain stimulation (DBS) may improve current clinical DBS treatment for neurological movement disorders, but control algorithms may perform differently across patients. New metrics are needed for comparing and…

Neurons and Cognition · Quantitative Biology 2016-05-31 Jeffrey Herron , Anca Velisar , Mahsa Malekmohammadi , Helen Bronte-Stewart , Howard Jay Chizeck

The goal of neural-symbolic computation is to integrate the connectionist and symbolist paradigms. Prior methods learn the neural-symbolic models using reinforcement learning (RL) approaches, which ignore the error propagation in the…

Machine Learning · Statistics 2020-07-29 Qing Li , Siyuan Huang , Yining Hong , Yixin Chen , Ying Nian Wu , Song-Chun Zhu

Closed-loop brain stimulation refers to capturing neurophysiological measures such as electroencephalography (EEG), quickly identifying neural events of interest, and producing auditory, magnetic or electrical stimulation so as to interact…

Signal Processing · Electrical Eng. & Systems 2022-10-12 Nicolas Valenchon , Yann Bouteiller , Hugo R. Jourde , Xavier L'Heureux , Milo Sobral , Emily B. J. Coffey , Giovanni Beltrame

We present a novel methodology for control of neural circuits based on deep reinforcement learning. Our approach achieves aimed behavior by generating external continuous stimulation of existing neural circuits (neuromodulation control) or…

Neurons and Cognition · Quantitative Biology 2020-06-15 Jimin Kim , Eli Shlizerman

This paper aims to develop a new human-machine interface to improve rehabilitation performance from the perspective of both the user (patient) and the machine (robot) by introducing the co-adaption techniques via model-based reinforcement…

Artificial Intelligence · Computer Science 2023-05-04 Kairui Guo , Adrian Cheng , Yaqi Li , Jun Li , Rob Duffield , Steven W. Su

Neuroprosthetic brain-computer interfaces function via an algorithm which decodes neural activity of the user into movements of an end effector, such as a cursor or robotic arm. In practice, the decoder is often learned by updating its…

Machine Learning · Statistics 2016-09-28 Josh Merel , David Carlson , Liam Paninski , John P. Cunningham

Animals achieve sophisticated behavioral control through dynamic coupling of the brain, body, and environment. Accordingly, the co-design approach, in which both the controllers and the physical properties are optimized simultaneously, has…

Neural and Evolutionary Computing · Computer Science 2025-03-10 Hiroki Tomioka , Katsuma Inoue , Yasuo Kuniyoshi , Kohei Nakajima
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