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Heterogeneity is an important property of any population experiencing a disease. Here we apply general methods of the theory of heterogeneous populations to the simplest mathematical models in epidemiology. In particular, an SIR…

Populations and Evolution · Quantitative Biology 2012-02-28 Artem S Novozhilov

Individual contributions to the spread of an epidemic vary widely due to an individual's location in a social network and their intrinsic ability to spread or contract diseases. While the effect of heterogeneous population structure and…

Populations and Evolution · Quantitative Biology 2026-05-14 Abhay Gupta , Nicholas W. Landry

We present a unified mathematical approach to epidemiological models with parametric heterogeneity, i.e., to the models that describe individuals in the population as having specific parameter (trait) values that vary from one individuals…

Populations and Evolution · Quantitative Biology 2012-02-14 Artem S. Novozhilov

We study the qualitative properties of a spatial diffusive heterogeneous SIR model, that appears in mathematical epidemiology to describe the spread of an infectious disease in a population. The model we consider consists in a system of…

Analysis of PDEs · Mathematics 2020-05-15 Romain Ducasse

The Susceptible-Infected-Recovered (SIR) model is the cornerstone of epidemiological models. However, this specification depends on two parameters only, which implies a lack of flexibility and the difficulty to replicate the volatile…

Populations and Evolution · Quantitative Biology 2020-11-17 Christian Gourieroux , Yang Lu

Population heterogeneity is a key factor in epidemic dynamics, influencing both transmission and final epidemic size. While heterogeneity is often modelled through age structure, spatial location, or contact patterns, differences in host…

Populations and Evolution · Quantitative Biology 2026-01-26 Tamás Tekeli , Andrea Pugliese , Cinzia Soresina

Most epidemic models assume equal mixing among members of a population. An alternative approach is to model a population as random network in which individuals may have heterogeneous connectivity. This paper builds on previous research by…

Physics and Society · Physics 2007-05-23 Erik Volz

We study dynamics of a variant of the SIR the model, where we assume that individuals respond differently to dynamics of the epidemic. Their heterogeneous response is modeled by the Preisach hysteresis operator. The degree of heterogeneity…

Dynamical Systems · Mathematics 2021-03-16 Dmitrii Rachinskii , Samiha Rouf

We study dynamics of spread of epidemics of SIR type in a realistic spatially-explicit geographical region, Southern and Central Ontario, using census data obtained from Statistics Canada, and examine the role of population mixing in…

Cellular Automata and Lattice Gases · Physics 2009-11-11 Henryk Fuks' , Anna T. Lawniczak , Ryan Duchesne

We study a well mixed SIR epidemic model with heterogeneous susceptibility and infectivity, allowing for an arbitrary joint distribution of these traits. Using an exact final size formulation and a branching process approximation for early…

Populations and Evolution · Quantitative Biology 2026-01-06 Mohamed El Khalifi

We investigate the long-time dynamics of a SIR epidemic model in the case of a population of pathogens infecting a homogeneous host population. The pathogen population is structured by a genotypic variable. When the initial mass of the…

Dynamical Systems · Mathematics 2023-06-05 Jean-Baptiste Burie , Arnaud Ducrot , Quentin Griette

The SIR model with spatially inhomogeneous infection rate is studied with numerical simulations in one, two, and three dimensions, considering the case that the infection spreads inhomogeneously in densely populated regions or hot spots. We…

Medical Physics · Physics 2020-12-25 Hidetsugu Sakaguchi , Yuta Nakao

Human behavior plays a critical role in shaping epidemic trajectories. During health crises, people respond in diverse ways in terms of self-protection and adherence to recommended measures, largely reflecting differences in how individuals…

Physics and Society · Physics 2026-01-30 Fabio Mazza , Gabriele Ricci , Francesca Colaiori , Stefano Guarino , Sandro Meloni , Fabio Saracco

A generalization of Kermack-McKendick model of epidemics to the case of inhomogeneous susceptibility of population is proposed. Some quantitative and qualitative features of epidemic process development in this situation are established.

Adaptation and Self-Organizing Systems · Physics 2008-11-20 E. Sh. Gutshabash , M. M. Brook

Standard epidemiological models for COVID-19 employ variants of compartment (SIR) models at local scales, implicitly assuming spatially uniform local mixing. Here, we examine the effect of employing more geographically detailed diffusion…

Since 1927, until recently, models describing the spread of disease have mostly been of the SIR-compartmental type, based on the assumption that populations are homogeneous and well-mixed. The focus of these models have typically been on…

Physics and Society · Physics 2014-07-23 Lara Goscé , David A W Barton , Anders Johansson

Motivated by our intention to use SIR-type epidemiological models in the context of dynamic networks as provided by large-scale highly interacting inhomogeneous human crowds, we investigate in this framework possibilities to reduce the…

Statistical Mechanics · Physics 2021-03-16 Matteo Colangeli , Adrian Muntean

We study extensions of the classical SIR model of epidemic spread. First, we consider a single population modified SIR epidemics model in which the contact rate is allowed to be an arbitrary function of the fraction of susceptible and…

Dynamical Systems · Mathematics 2021-12-17 Martina Alutto , Giacomo Como , Fabio Fagnani

Networks of contacts capable of spreading infectious diseases are often observed to be highly heterogeneous, with the majority of individuals having fewer contacts than the mean, and a significant minority having relatively very many…

Physics and Society · Physics 2016-12-21 César Parra-Rojas , Thomas House , Alan J. McKane

We propose an extension of the classical susceptible infectious recovered (SIR) model that incorporates the effects of spatial propagation of an epidemic through a small number of additional compartments. The model is designed to capture…

Numerical Analysis · Mathematics 2026-03-02 M. Soledad Aronna , Mariana Bergonzi , Ernesto Kofman
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